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  • Md. Shaifur Rahman Biotechnology & Genetic Engineering Khulna University Khulna-9208

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    This document discusses key components and interactions within the immune system. It outlines the differentiation of stem cells into lymphoid and myeloid lineages including lymphocytes and phagocytes. It describes the roles of lymphocytes, phagocytes, antibodies, complement proteins, cytokines and other cells in responding to antigens, presenting antigens, and initiating inflammation. It also summarizes processes like phagocytosis, opsonization, antigen presentation, T cell-dependent and -independent B cell activation, antibody production, and the immune response to acute infections.

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    General Immunology

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    This document discusses key components and interactions within the immune system. It outlines the differentiation of stem cells into lymphoid and myeloid lineages including lymphocytes and phagocytes. It describes the roles of lymphocytes, phagocytes, antibodies, complement proteins, cytokines and other cells in responding to antigens, presenting antigens, and initiating inflammation. It also summarizes processes like phagocytosis, opsonization, antigen presentation, T cell-dependent and -independent B cell activation, antibody production, and the immune response to acute infections.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPT, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    89 views29 pages

    Md. Shaifur Rahman Biotechnology & Genetic Engineering Khulna University Khulna-9208

    Uploaded by

    mdshaifur7023
    This document discusses key components and interactions within the immune system. It outlines the differentiation of stem cells into lymphoid and myeloid lineages including lymphocytes and phagocytes. It describes the roles of lymphocytes, phagocytes, antibodies, complement proteins, cytokines and other cells in responding to antigens, presenting antigens, and initiating inflammation. It also summarizes processes like phagocytosis, opsonization, antigen presentation, T cell-dependent and -independent B cell activation, antibody production, and the immune response to acute infections.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPT, PDF, TXT or read online from Scribd
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    of 29

    Md.

    Shaifur Rahman
    Biotechnology & Genetic
    Engineering
    Khulna University
    Khulna-9208
    Email: mdshaifur@gmail.com
    Lysome in
    Tear
    Stem cell

    Lymphoid Stem Cell Myeloid Stem Cell

    Plasma Memory
    Cell Cell

    Basophill
    Eosuinophil

    Neutrophil

    Mast Cell
    Monocyte
    Lymphocytes
    Phagocytes
    Mononuclear
    phagocyte Neutrophil Eosinophil
    Auxiliary cells

    Basophil Mast cell Platelets

    Inflammatory mediators
    Complement

    Antigen
    Lysis Opsonized
    Antigen
    Antigen

    Chemotaxis

    Phagocyte
    Interaction between Lymphocytes & Phagocytes

    Aid recognition
    Antibodies

    Antigen
    presentation
    Activation
    Cytokines

    Activation
    Function of lymphocytes

    Lymphokine Secretion
    &
    Antigen
    Presentation B Cell Activation

    Antibody Production
    Interaction between Cells & Antigens

    Cytotoxicity

    Virally infected cell and some tumourous


    cells
    Phagocytosis
    Opsonization, binding and phagocytosis
    Opsonization
    Phagocyte Opsonin Binding

    Complement
    C 3b
    ++

    Antibody ++
    Antibody &
    Complement
    ++++
    C3b
    Antigen presentation

    Fc receptor

    APC

    Antigen

    MHC II Processed Ag
    Non-specific
    receptor
    Function of B cell

    Ag

    H
    Dendritic cells

    Macropinocytosis

    Dendritic cells
    T Dependent B Cell Activation

    APC
    T-dependent
    Ag
    Processed
    MHC II
    Ag

    B-cell
    epitope Antibody
    T-cell Activated B-cell
    Production
    epitope
    T-independent B-cell activation

    Antigen

    Activated B-cell

    Ig /Antibody

    Production of
    Antibody
    T-independent B-cell activation

    Mitogen

    Activation

    Mitogen
    receptor

    Production of
    Antibody
    Antigen
    selection

    Plasma Plasma Plasma Plasma Plasma Plasma


    cell cell cell cell cell cell

    Memory
    Cell

    Production of
    antibody (2)
    Cross-reactivity

    Antigen

    Activation

    Production of
    Antibody
    Variable
    Antibody
    Region
    Intra Chain
    Light Chain Disulfide Bond

    Heavy chain

    Inter
    Chain Constant Region
    Disulfide
    Bonds
    Heavy chain

    Hinge
    region
    Variable
    Region Carbohydrate residue
    Light Chain
    The immune system in acute inflammation

    Antigen
    Inflammatory mediators
    Infected cell
    Siteofof
    Site
    Inflammation
    Inflamation
    Reaction to Extracellular and Intracellular Pathogen

    Antibody
    Virus &
    Complement

    Interferon
    Mast Cell Degranulation

    Degranulation
    Cross
    Inflammatory Linking
    mediator
    APC

    Cytokine

    Mast Cell

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