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  • Larson 1980

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    Cati Jurca
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    This study tested the topical anti-inflammatory effects of piroxicam in rodent models. The researchers found that piroxicam applied topically was a potent inhibitor of inflammation induced by carrageenin or complete Freund's adjuvant in rats, with comparable potency to oral administration. Topical piroxicam was also more potent than topical bufexamac or phenylbutazone at reducing inflammation in a rat adjuvant arthritis model.

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    This study tested the topical anti-inflammatory effects of piroxicam in rodent models. The researchers found that piroxicam applied topically was a potent inhibitor of inflammation induced by carrageenin or complete Freund's adjuvant in rats, with comparable potency to oral administration. Topical piroxicam was also more potent than topical bufexamac or phenylbutazone at reducing inflammation in a rat adjuvant arthritis model.

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    Larson 1980

    Uploaded by

    Cati Jurca
    This study tested the topical anti-inflammatory effects of piroxicam in rodent models. The researchers found that piroxicam applied topically was a potent inhibitor of inflammation induced by carrageenin or complete Freund's adjuvant in rats, with comparable potency to oral administration. Topical piroxicam was also more potent than topical bufexamac or phenylbutazone at reducing inflammation in a rat adjuvant arthritis model.

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    Agents Actions. 1980 Jun;10(3):246-51.

    The topical anti-inflammatory effects of piroxicam in rodents.


    Larson DL, Lombardino JG.

    Abstract
    Piroxicam is a structurally novel, long-acting anti-inflammatory drug with potent activity following oral administration in animal models of inflammation and in human inflammatory diseases. The present studies, performed in rats, demostrate that topically applied piroxicam is a potent inhibitor of inflammation induced by either carrageenin or complete Freund's adjuvant. Comparable potencies (ED50 approximately 1--5 mg/kg) were obtained for topically and orally administered piroxicam in these models of inflammation. The potency of topical piroxicam exceeds that of topically applied bufexamac or phenylbutazone in the rat adjuvant arthritis model. PMID:7405751 [PubMed - indexed for MEDLINE]

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