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Sulfonamide (Midterm 2)
Sulfonamide (Midterm 2)
Metabolism
Sulfonamides
• Also called Sulfa drugs
• Drugs that inhibit folic acid synthesis. Folic
acid is necessary for the synthesis of purine
and pyrimidine which are precursors of DNA
and RNA
• Not used much anymore because of the
emergence of resistant bacteria
• They remain as an inexpensive and
effective treatment for UTI and trachoma
• Examples are Sulfadiazine, sulfisoxazole,
sulfasalazine ( ulcerative colitis and Crohn
disease )
Cotrimoxazole