Histidine, An intersteing amino acid

Histidine acts as a general base in the conversion of malate to oxaloacetate. Histidine abstracts a proton from the 0H group of malate ion. In this case before the transfer of hydrogen Histidine is in its neutral ion. Another impetrating fact regarding Histidine is that its side chain contan imidazole ring. The pKa value for the ring is approximately 7.0, so at physiological pH, both the acid and base forms are present. In this case ai important resonance phenomenon took place, where the H atom bonded to N1 nitrogen changes its position to N3 nitrogen. Thus either of the two ring nitrogen can release a proton (H+) to produce the conjugate base.
AN(1)H AN(3)H

AN- + H+