Encontro Nacional de Qumica Analtica Qumica Analtica Moderna: Uma contribuio para a Qumica Limpa 14 a 17 de Outubro de 2003

WORKSHOP SENSORES

"Sensores Aplicados Clnica Mdica"

Prof Dr. Jos Luiz de Lima Filho LIKA - (UFPE)

Introduction
It is hard to place a price tag either on human life or on the quality of life. This has become starkly evident since the attack on the World Trade Center on September 11, 2001. There is a similar, yet silent, crisis that is dramatically affecting the quality of life for individualslack of access to affordable and high-quality healthcare.

Technology is the key to enhancing the quality of life

Consider the following facts:

In a recent report, the Institute of Medicine concluded The U.S. healthcare delivery system does not provide consistent, high-quality medical care to all people Experts estimate that as many as 98,000 people die in any given year from medical errors that occur in hospitals. More people die annually from medication errors than from workplace injuries.

And Then

Healthcare spending in the U.S. soared to US$1.42 trillion in 2001, as across-the-board increases fueled the fastest annual growth in a decade Seven major diseases accounted for 80% of deaths in the United States in 1990: heart disease, cancer, diabetes, arthritis, chronic bronchitis, influenza, and asthma In Brazil 32% of deaths are by heart disease, external causes (15%), cancer (15%) following by chronic bronchitis, pneumonia and asthma (11%) and parasitoses and infections (9%). For many of these health conditions, early, systematic intervention would be highly beneficial. With universal access to information, todays healthcare consumer is demanding more options and taking control in determining the course of healthcare.

Responding to the Healthcare Challenge

Reduce healthcare costs while maintaining the high quality of care; provide access to care for as many people as possible; provide easy access to specialized professionals anywhere and at anytime; shift the focus of healthcare expenditures from treatment to prevention through wellness programs; control length of hospital stay and decentralize the provision of healthcare; address the increase in the aging population and caring for chronically ill patients.

Actual procedure - HOME

Complex Hospital

e Tim

Cost

Ris

Transport, Nurse, exam appointment Transport, Nurse, exam appointment

Actual procedure - hospital

Hospital Local Complex Hospital

Maternidade

e Tim

Cost

Ris

Paciente Removido

Patient exam

Patient is re-exam

Transport, Nurse, exam appointment Transport, Nurse, exam appointment

How to Improving Healthcare ?

These include a healthcare system that is:

safe, effective, patient-centered, and provides timely, efficient, and equitable care that does not vary in quality across the country.

Information is at the heart of a successful healthcare system. How to get it???????

New Procedure UFPE

Complex Hospital HC UFPE

Maternidad e

d pee

Safety

Su rv

iv a

SUCESS Conexo via Internet

LIKA,HC,Informatics-UFPE

Intranet System - UFPE

Laboratory Doctor

Internet

Biosensors - Glucose -Uric acid -Urea -TGO,TGP

Intranet
Local link

UCL Patient room

Nurse Monitoring Blood pressure Temperature Liquid Flow Diurese

Services - Alarm - INTERNET - Reports

Retornar

Internet System - UFPE

Royal Brompton Londres - GB

UCMF

HOSPITAIS/ POSTOS DE SADE

CISAM

HOSPITAIS/ POSTOS DE SADE

HOSPITAIS/ POSTOS DE SADE

CSSE

Casa de Sadeda Encruzilhada -Caruaru - PE Maternidade Santa Efignia UPE Fetal Unidade de Cardiologia & Medicina

How improve the health quality?

We have to know which going on. How? Sensors Biosensors System of information Sensors: Temperature, pH, gases, etc.

Remote sensor

Specific = Biosensor

Biosensors combine the extreme selectivity of living systems (such as enzymes, antibodies, nucleic acids, micro-organisms or cells) with the miniaturization techniques and processing power of modern microelectronics or optoelectronics - a prime example of technology convergence. Biosensors is relying on cross-disciplinary collaborations between engineering, biochemistry, and molecular biology researchers

Global Biosensors Markets

Biosensor market application

Clinical (89%), Industrial (6%), Environmental/waste water (3%) Food & beverage applications (1.5%). by 2005 medical biosensor sales will reach over $8 billion and hold the overwhelming share (96%) of all biosensor sales

Where are you going to use them??

Sport Home Travel

Work

Hospital

Biosensor

Biosensors are defined as analytical devices incorporating a biological material (e.g., tissue, microorganisms, organelles, cell receptors, enzymes, antibodies, nucleic acids, and others), a biologically derived material, or biomimic intimately associated with or integrated within a physicochemical transducer or transducing microsystem: optical, electrochemical, thermometric, piezoelectric or magnetic

Glucose Biosensor Diabetes application

Glucose Biosensor version 1 Optical

Glucose Biosensor version 2 Electrochemical

Glucose Biosensor version 3 Electrochemical

Figure 2: Calibration Curve

2,5

2,0

Current (uA)

1,5

1,0

0,5

0,0 0 100 200 300 400 500

Concentration mM

LIKAs glucose sensor

Biosensor commercial

Biosensor V 1.0

V 1.0

Biosensor V 1.1

Hardware FPGA Microcontrolad or RAM EPROM

Fabricante Xilinx MHS Toshiba AMD

Modelo SrieXC40XX Intel(P-80C32-16) TC551001BPL-70 AM27C512

V 1.1

Glucose Implantable sensor

Optical glucose meter

Microchips

Operational scheme of a molecular diagnostics laboratory

Schematic for the fabrication of a MEMS sensor

Protocol for the use of a DNA microarray

Diagram of a microcantilever biosensor

Tuberculose Dengue Pneumonia Leucemia

Piezoelectric Biosensor
Chitosan film

Crystal Electrodo Quartz disk

Gold electrode

Oscilator
Frequency measure Power Suppy

QCM System
0 ,4 0 ,3
(F1 -F2 )/F1 ,2 0 s s DNA d s DNA S e mDNA Imo b iliz a o Cris ta l Pa d r o

0 ,1 0

Frequency measure

Crystal

System of information Mobile sensor network architecture

Goals: Development of an architecture for a wireless body area network (BAN) of intelligent sensors. The individual sensors (monitors) will be integrated into a distributed wireless system for monitoring of vital physiological human signals.

Mobile sensor network architecture

Hospital
sensors

Personal Server (PDA, Cell phome)

Local Server

Hospital information system (HIS) Mobile intelligent network

Wireless communication

Mobile sensor network architecture

Applications (Personal Well Assistant)

Tele-homecare Hospital patient monitoring Real-time personal monitor

Wireless Intelligent sensor

Wireless Intelligent sensor features:

Data acquisition Local data processing Real-time feedback to the patient and for the Medical Center Can reduce the number of hospitalization and nursing visits by acting as a personal guardian angel (warn the user/medical emergency ou contact a specialized medical response service) Communication facilities with a local server Low power Sensors: ECG Glucose Temperature

Local Server

Features: Local processing with each of the sensors individually Download data from each sensor, checks data consistency Communication protocol implementation with a Central workstation and Internet (Hospital)

Smart shirt sensor

Applications of Smart shirt

IEEE ENGINEERING IN MEDICINE AND BIOLOGY MAGAZINE MAY/JUNE 2003 47

FUTURE???

Muito Obrigado !

Venha conhecer o Recife !

OBRIGADO!!!!

Setor de Tecnologias da Informao em Sade do LIKA, UFPE zeluiz@lika.ufpe.br, Tel. (0 xx 81) 271-8489