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  • Osteoarthritis

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    nebulla
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    Obesity is a disorder where calorie intake exceeds energy expenditure, resulting in excessive fat accumulation. Osteoarthritis is a common joint disease causing pain, swelling, and loss of function. Obesity is a major risk factor for osteoarthritis in most joints, as excess body weight places greater stress on joints. The document discusses how inflammation from cytokines like TNF-alpha and IL-1 beta can lead to joint inflammation in osteoarthritis and how the Wnt signaling pathway regulates bone formation and resorption, with genes in this pathway like FRZB and LRP5 linked to osteoarthritis in the hip and spine.

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    Obesity is a disorder where calorie intake exceeds energy expenditure, resulting in excessive fat accumulation. Osteoarthritis is a common joint disease causing pain, swelling, and loss of function. Obesity is a major risk factor for osteoarthritis in most joints, as excess body weight places greater stress on joints. The document discusses how inflammation from cytokines like TNF-alpha and IL-1 beta can lead to joint inflammation in osteoarthritis and how the Wnt signaling pathway regulates bone formation and resorption, with genes in this pathway like FRZB and LRP5 linked to osteoarthritis in the hip and spine.

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    19 views4 pages

    Osteoarthritis

    Uploaded by

    nebulla
    Obesity is a disorder where calorie intake exceeds energy expenditure, resulting in excessive fat accumulation. Osteoarthritis is a common joint disease causing pain, swelling, and loss of function. Obesity is a major risk factor for osteoarthritis in most joints, as excess body weight places greater stress on joints. The document discusses how inflammation from cytokines like TNF-alpha and IL-1 beta can lead to joint inflammation in osteoarthritis and how the Wnt signaling pathway regulates bone formation and resorption, with genes in this pathway like FRZB and LRP5 linked to osteoarthritis in the hip and spine.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPT, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as ppt, pdf, or txt
    of 4

    Obesity and Osteoarthritis

    Obesity is an energy balance disorder in which nutrient intake chronically exceeds energy expenditure, resulting in excessive white adipose tissue accumulation. Osteoarthritis (OA) Common disease, clinically manifested by joint pain, swelling and progressive loss of function.
    Obesity is an important risk factor for OA in most joints.

    Inflammatory joint disease

    TNFa/ IL-1b
    11b-HSD1

    Joint inflammation
    GCs

    DKK1 Osteoblasts Synovial fibroblasts

    DKK1 Frzb

    Wnt2

    Bone Resorption

    Bone Formation

    Wnt signalling and OA

    Transcription of Wnt target genes

    SNPs in the FRZB gene is associated with hip osteoarthritis and a polymorphism in the LRP5 gene was also reported with spinal osteophytosis.
    Luyten et al. 2009; Bone 44, 522-527

    Thank you all !

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