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    Book 1

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    Stephen Eleserio
    The document summarizes information about several antibiotics including ofloxacin, ampicillin, penicillin, polymyxin B, tetracycline, streptomycin, and quinolone. It provides their initials, type, spectrum of activity, mechanism of action, and target species. For example, it notes that ofloxacin is a fluoroquinolone with broad spectrum bacteriostatic activity that inhibits DNA replication and cell division by targeting DNA gyrase in Gram-negative and topoisomerase IV in Gram-positive bacteria.

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    Book 1

    Uploaded by

    Stephen Eleserio
    11 views2 pages
    The document summarizes information about several antibiotics including ofloxacin, ampicillin, penicillin, polymyxin B, tetracycline, streptomycin, and quinolone. It provides their initials, type, spectrum of activity, mechanism of action, and target species. For example, it notes that ofloxacin is a fluoroquinolone with broad spectrum bacteriostatic activity that inhibits DNA replication and cell division by targeting DNA gyrase in Gram-negative and topoisomerase IV in Gram-positive bacteria.

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    Book1

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    The document summarizes information about several antibiotics including ofloxacin, ampicillin, penicillin, polymyxin B, tetracycline, streptomycin, and quinolone. It provides their initials, type, spectrum of activity, mechanism of action, and target species. For example, it notes that ofloxacin is a fluoroquinolone with broad spectrum bacteriostatic activity that inhibits DNA replication and cell division by targeting DNA gyrase in Gram-negative and topoisomerase IV in Gram-positive bacteria.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as XLSX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as xlsx, pdf, or txt
    11 views2 pages

    Book 1

    Uploaded by

    Stephen Eleserio
    The document summarizes information about several antibiotics including ofloxacin, ampicillin, penicillin, polymyxin B, tetracycline, streptomycin, and quinolone. It provides their initials, type, spectrum of activity, mechanism of action, and target species. For example, it notes that ofloxacin is a fluoroquinolone with broad spectrum bacteriostatic activity that inhibits DNA replication and cell division by targeting DNA gyrase in Gram-negative and topoisomerase IV in Gram-positive bacteria.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as XLSX, PDF, TXT or read online from Scribd
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    Download as xlsx, pdf, or txt
    of 2

    Antibiotic

    Initials

    Type

    Spectrum

    Activity

    Inihibits /Destroys

    Ofloxacin

    OFX

    Fluoroquinolone

    Broad

    Bacteriostatic

    DNA replication (cell division) Production of Peptidoglycan cell wall Production of Peptidoglycan cell wall Cell membrane structure and permeability DNA Translation DNA Translation

    Ampicillin

    A or AP

    Beta-Lactam

    Broad

    Bacteriostatic

    Penicillin

    P or PG

    Beta-Lactam

    Broad

    Bacteriostatic (Bactericidal)

    Polymyxin B

    PB

    cyclic cationic polypeptide antibiotic


    Polyketide aminoglycosides

    Narrow

    Bactericidal Bacteriostatic (except PA and Proteus) Bactericidal

    Tetracycline Streptomycin

    T S

    Broad Broad

    Quinolone

    Synthetic

    Synthetic Broad

    Bacteriostatic

    DNA replication (cell division)

    Target

    Against

    Effective on (based on results) 1-PA,SA 2-EC, BS

    Species

    DNA Gyrase (G-) and Topoisomerase 4 (G+) Transpeptidase (cross-bridges links) Transpeptidase (cross-bridges links) Cell membrane components 30S subunit of microbial ribosomes. Misread the CODON DNA Gyrase (G-) and Topoisomerase 4 (G+)

    G- and G+

    G+ (all) and G(some)

    1-EC 2-SA Penicillium chrysogenum formerly Penicillum notatum

    Usually G+

    3-PA,EC

    Resistant Gbacilli (except Proteus) G- and G+ G- and G+

    3- SA, BS 1-EC, BS 2-PA 3-SA 2-PA

    Paenibacillus polymixa.
    Streptomyces genus Streptomyces griseus

    G- and G+

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