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    What Is The Action of Heparin and What Would You Give To Counter Overdose of Heparin That Can Give A Life Threatening Bleed?

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    Kartik Kumarasamy
    Heparin is an anticoagulant that works by potentiating the activity of antithrombin, which forms complexes with coagulation factors like thrombin and factor X to inactivate them irreversibly. This can cause life-threatening bleeding from overdose. Protamine counters heparin overdose by binding to heparin to form an inactive complex, and a dose of 1mg protamine for every 100 units of heparin can effectively neutralize heparin's effects in cases of severe bleeding.

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    What Is The Action of Heparin and What Would You Give To Counter Overdose of Heparin That Can Give A Life Threatening Bleed?

    Uploaded by

    Kartik Kumarasamy
    12 views1 page
    Heparin is an anticoagulant that works by potentiating the activity of antithrombin, which forms complexes with coagulation factors like thrombin and factor X to inactivate them irreversibly. This can cause life-threatening bleeding from overdose. Protamine counters heparin overdose by binding to heparin to form an inactive complex, and a dose of 1mg protamine for every 100 units of heparin can effectively neutralize heparin's effects in cases of severe bleeding.

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    Heparin is an anticoagulant that works by potentiating the activity of antithrombin, which forms complexes with coagulation factors like thrombin and factor X to inactivate them irreversibly. This can cause life-threatening bleeding from overdose. Protamine counters heparin overdose by binding to heparin to form an inactive complex, and a dose of 1mg protamine for every 100 units of heparin can effectively neutralize heparin's effects in cases of severe bleeding.

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    12 views1 page

    What Is The Action of Heparin and What Would You Give To Counter Overdose of Heparin That Can Give A Life Threatening Bleed?

    Uploaded by

    Kartik Kumarasamy
    Heparin is an anticoagulant that works by potentiating the activity of antithrombin, which forms complexes with coagulation factors like thrombin and factor X to inactivate them irreversibly. This can cause life-threatening bleeding from overdose. Protamine counters heparin overdose by binding to heparin to form an inactive complex, and a dose of 1mg protamine for every 100 units of heparin can effectively neutralize heparin's effects in cases of severe bleeding.

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    8.

    What is the action of heparin and what would you give to counter overdose of heparin that can give a life threatening bleed? An inhibitor of blood coagulation because of its action in potentiating the activity of antithrombin. Heparin dramatically potentiates the formation of complexes between antithrombin and activated serine protease coagulation factors, thrombin (IIa) and factors IXa, Xa and XIa. The complex formation inactivates these factors irreversibly.

    Life threatening bleeding may be because of excessive prolonged anticoagulant effect of heparin. Protamine is able to inactivate heparin immediately and for severe bleeding a dose of 1mg/100units heparin provides effective neutralization. It binds to heparin to form a stable ion
    pair which does not have anticoagulant activity; on its own, protamine has a weak anticoagulant effect. The complex of heparin and protamine is then removed and broken down by the reticuloendothelial system.

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