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Drug Absorption: Team Kester
Drug Absorption: Team Kester
Drug Absorption: Team Kester
Team Kester
What is the process by which drugs are transferred from the site of entry into the body to the bloodstream?
Age Groups
Neonate- birth to 1 year of age
delivery, intramuscular, subcutaneous) Topical (skin, lungs, vagina, ears, nose, eyes)
Enteral
In geriatric patients, oral medications are often taken
Parenteral
In pediatric patients, intramuscular injections
are avoided due to tissue damage In neonate patients, intramuscular absorption is erratic due to lack of muscle and fat tissue
Topical
absorbed faster because their skin is very thing and they have a large body surface area In pediatric patients, skin disruptions such as burns and eczema increase absorption
of drugs than enteric-coated tablets Lipid solubility, molecular weight and polarity
flow to GI tract In neonate patients, decreased renal blood flow In pediatric patients, diminished muscle mass may reduce blood flow
Stomach Acidity
In neonate patients, variable
gastric pH leads to diminished absorption In pediatric patients, gastric pH is less acidic In geriatric patients, gastric acid secretin is decreased
Gastrointestinal Mobility
In neonate patients, prolonged
gastric transit time leads to diminished absorption Gastric emptying rates are faster for pediatric patients than in neonates In geriatric patients, gastric emptying time is increased
Both B and D
To make sure medications are given safely
the right patient type. Improves patients experiences They are getting the correct drug in the correct form in the correct dosage Increases efficiency The correct drug is going to the correct patient (hopefully without human error)
Credits
RN, Carol Taylor, CSFN, MSN, PhD Carol Lillis RN, MSN Priscilla
LeMone RN, DSN, FAAN Pamela Lynn RN, . Fundamentals of Nursing, 7th Edition. Lippincott Williams & Wilkins. <vbk:9781451105957#page(1683)>.
http://www.merckmanuals.com/professional/clinical_pharmacology/pharmaco
kinetics/drug_absorption.html
http://howmed.net/pharmacology/factors-affecting-absorption-of-drugs/ http://www.clinchem.org/content/35/7/1337.full.pdf