DRUG STUDY Name of the Drug Silver sulfadiazine (Thermazene) Classification Local anti-infectives Indication - To prevent or treat wound

infection in second and third degree burns Mechanism of Action A broad-spectrum sulfonamide that acts on cell membrane and cell wall; its bactericidal for many gram positive and gram negative organisms. Interactions Drug-drug. Topical proteolytic enzymes: may inactivate enzymes. Avoid using together. Drug-lifestyle. Sun exposure: may cause photosensitivity. Advise patient to avoid excessive sun exposure Adverse Reactions Hematologic: Leukopenia Metabolic: altered serum osmolality Skin: pain, burning, rash, pruritus, skin necrosis, skin discoloration. Nursing Consideration - Use sterile application technique to prevent wound infections. - Use drug only on a affected areas. Keep these areas medicated at all times. - Bathe patient daily, if possible. - inspect pts skin daily, and note any changes. Notify prescriber if burning or excessive pain develops. - Tell prescriber if hepatic or renal dysfunction occurs; drug may need to be stopped.

DRUG STUDY Name of the Drug Meperidine hydrochloride ( Demerol) Classification Opioid analgesic Indication - Moderate to severe pain Mechanism of Action Unknown. Binds with opiate receptors in the CNS, altering perception of and emotional response to pain. Adverse Reaction CNS: sedation, somnolence, clouded sensorium, euphoria, dizziness, seizures, light-headedness CV: hypotension, bradycardia, cardiac arrest, shock GI: constipation, ileus, nausea, vomiting GU: urine retention Musculoskeletal: muscle twitching Respiratory: respiratory depression, respiratory arrest Skin: pruritus, urticaria, diaphoresis Other: phlebitis after I.V. delivery Interaction Drug-drug. Cimetidine: may increase respiratory and CNS depression. Monitor patient closely. Phenytoin: May decrease meperidine level. Watch for decreased analgesia. Drug-lifestyle: Alcohol use: may cause additive effect. Discourage use together. Nursing Consideration drug may be used in some patients who are allergic to morphine. Syrup has local anesthetic effect. Give with full glass of water.

DRUG STUDY Name of the Drug Naproxen (Naprox) Classification Nonsteroidal antiinflammatory drugs Indications mild to moderate pain Mechanism of Action Unknown. May inhibit prostaglandin synthesis to produce anti-inflammatory, analgesic and antipyretic effects. Adverse Reaction CNS: headache, drowsiness, dizziness, vertigo. CV: edema, palpitations EENT: tinnitus, visual disturbances GI: epigastric pain, nausea, heartburn, diarrhea. Hematologic: increased bleeding time Metabolic: Hyperkalemia Respiratory: dyspnea Skin: pruritus, rash,urticaria Nursing Consideration - Monitor CBC and renal and hepatic function every 4 to 6 months during long term therapy. - Serious GI toxicity, including peptic ulcers and bleeding, can occur in patient.

DRUG STUDY Name of the Drug Morphine hyrochloride Classification Opioid analgesic Indication Severe pain Mechanism of Action Unknown. Binds with opiate receptors in the CNS, altering perception of and emotional response to pain. Adverse Reaction CNS: sedation, somnolence, clouded sensorium, euphoria, dizziness, seizures, lightheadedness CV: hypotension, bradycardia, cardiac arrest, shock GI: constipation, ileus, nausea, vomiting GU: urine retention Musculoskeletal: muscle twitching Respiratory: respiratory depression, respiratory arrest Skin: pruritus, urticaria, diaphoresis Other: phlebitis after I.V. delivery Nursing Consideration Contraindicated in pts with GI obstruction. Use with caution in pts with circulatory shock, biliary tract disease, CNS depression, acute alcoholism.

DRUG STUDY Name of Drug Mannitol (Osmitrol) Classification Diuretics Indication pulmonary edema edema of the airways Mechanism of Action Increases osmotic pressure of glomerular filtrate, inhibiting tubular reabsorption of water and electrolytes; drug elevates plasma osmolality, increasing water flow into extracellular fluid. Adverse Reaction CNS: seizure, headache. Fever CV: edema, hypo and hypertension, heart failure EENT: blurred vision, rhinitis GI: thrist, dry mouth, nausea, vomiting GU: urine retention Metabolic: dehydration Skin: local pain, urticaria Other: chills Nursing Consideration drug can be used to measure glomerular filtration rate. To relieve thirst, give frequent mouth care fluids