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    Rosiglitazone is an anti-diabetic drug that belongs to the thiazolidinedione class. It works by activating the peroxisome proliferator-activated receptor gamma (PPARγ), which improves insulin sensitivity. Rosiglitazone may also have anti-inflammatory effects and has been studied for treatment of ulcerative colitis. It is a solid drug that is slightly soluble in water and soluble in ethanol and DMF, with a melting point of 122-123°C.

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    Rosiglitazone is an anti-diabetic drug that belongs to the thiazolidinedione class. It works by activating the peroxisome proliferator-activated receptor gamma (PPARγ), which improves insulin sensitivity. Rosiglitazone may also have anti-inflammatory effects and has been studied for treatment of ulcerative colitis. It is a solid drug that is slightly soluble in water and soluble in ethanol and DMF, with a melting point of 122-123°C.

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    11 views2 pages

    Rosi Profile EDITED

    Uploaded by

    sudhapharma4582
    Rosiglitazone is an anti-diabetic drug that belongs to the thiazolidinedione class. It works by activating the peroxisome proliferator-activated receptor gamma (PPARγ), which improves insulin sensitivity. Rosiglitazone may also have anti-inflammatory effects and has been studied for treatment of ulcerative colitis. It is a solid drug that is slightly soluble in water and soluble in ethanol and DMF, with a melting point of 122-123°C.

    Copyright:

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    Download as DOC or read online from Scribd
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    of 2

    ROSIGLITAZONE

    Introduction:

    Rosiglitazone is an anti-diabetic drug in the thiazolidinedione


    class of drugs. Apart from its effect on insulin resistance, it appears
    to have an anti-inflammatory effect: The medication might also be
    effective in the treatment of mild to moderate Ulcerative Colitis,
    due to its antiinflammatory properties as a PPAR ligand.

    Chemical Structure

    Chemical name: 5-[4-(2-[methyl(pyridin-2-yl)amino] ethoxy)

    benzyl]thiazolidine-2,4-dione.

    Chemical Formula: C18H19N3O3S

    Molecular Weight: 357.428 g/mol

    Drug Description:
    Solubility: Slightly soluble in water, Soluble in Ethanol and
    DMF.

    State:Solid
    Melting Point: 122-123 oC
    Experimental LogP/Hydrophobicity: 2.4
    Protein Binding: 99.8% bound to plasma proteins.
    Half Life: 3-4 hours
    Mecanism of Action:
    Action of rosiglitazone is through activation of the
    intracellular receptor class of the peroxisome proliferator-
    activated receptors (PPARs), specifically PPARγ. Rosiglitazone is
    a selective ligand of PPARγ, and has no PPARα-binding action.

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