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  • Notch4 Overexpression in Ameloblastoma Correlates With The Solid or Multicystic Phenotype

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    University Malaya's Dental Sciences Research
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    This study examined the expression of Notch receptors and ligands in solid/multicystic (SA), unicystic (UA), and recurrent (RA) ameloblastoma subtypes. The researchers found that Notch4 was overexpressed in 82.6% of SA cases compared to 4.5% of UA cases and 52.6% of RA cases, suggesting a correlation between Notch4 signaling and the solid/multicystic phenotype. Ligand expression was lower than receptor expression in all subtypes, and Notch2 and Jagged2 were not detected, indicating the tumor epithelium has an early differentiation stage. The findings suggest Notch signaling molecules may play different roles in different amelo

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    Notch4 Overexpression in Ameloblastoma Correlates With the Solid or Multicystic Phenotype

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    This study examined the expression of Notch receptors and ligands in solid/multicystic (SA), unicystic (UA), and recurrent (RA) ameloblastoma subtypes. The researchers found that Notch4 was overexpressed in 82.6% of SA cases compared to 4.5% of UA cases and 52.6% of RA cases, suggesting a correlation between Notch4 signaling and the solid/multicystic phenotype. Ligand expression was lower than receptor expression in all subtypes, and Notch2 and Jagged2 were not detected, indicating the tumor epithelium has an early differentiation stage. The findings suggest Notch signaling molecules may play different roles in different amelo

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    6 views2 pages

    Notch4 Overexpression in Ameloblastoma Correlates With The Solid or Multicystic Phenotype

    Uploaded by

    University Malaya's Dental Sciences Research
    This study examined the expression of Notch receptors and ligands in solid/multicystic (SA), unicystic (UA), and recurrent (RA) ameloblastoma subtypes. The researchers found that Notch4 was overexpressed in 82.6% of SA cases compared to 4.5% of UA cases and 52.6% of RA cases, suggesting a correlation between Notch4 signaling and the solid/multicystic phenotype. Ligand expression was lower than receptor expression in all subtypes, and Notch2 and Jagged2 were not detected, indicating the tumor epithelium has an early differentiation stage. The findings suggest Notch signaling molecules may play different roles in different amelo

    Copyright:

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    Notch4 overexpression in ameloblastoma correlates with the solid/multicystic phenotype Type: Article Abstract: Objective.

    Notch signaling has been implicated in cell fate decisions during odontogenesis and tumorigenesis of some odontogenic neoplasms; however, its role in solid/multicystic (SA), unicystic (UA), and recurrent (RA) ameloblastoma remains unclear. The aim of this study was to determine Notch receptor and ligand expressions in these subtypes and to speculate on their significance. Methods. Notch receptors (Notch1, 2, 3, 4) and ligands (Jagged1, 2, and Delta1) were examined immunohistochemically in SA (n = 23), UA (n = 22), and RA (n = 19). Results. Notch4 overexpression in SA (n = 19/23; 82.6%) compared with UA (n = 1/22; 4.5%) or RA (n = 10/19; 52.6%) (P < .05) suggests positive correlation between Notch4 signaling and ameloblastomas with a solid/multicystic phenotype. Ligand (Jagged1 and Delta1) underexpression compared with their receptors (Notch1, 3, 4) (P < .05) and nonreactivity for Notch2 and Jagged2 in all 3 subsets suggests that ameloblastoma epithelium belongs to an earlier stage of differentiation (equivalent to inner enamel epithelium of developing tooth germ) before lineage commitment. Conclusion. Present findings suggest that Notch signaling molecules may play differing roles in the acquisition of different ameloblastoma phenotypes. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010; 110: 224-233)

    Author

    Siar, C. H. Nagatsuka, H. Chuah, K. S. Rivera, R. S. Nakano, K. Ng, K. H. Kawakami, T.

    Source ISSN DOI Volume (Issue) Page Year

    Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology 1079-2104 10.1016/j.tripleo.2010.03.009 110(2) 224-233 2010

    Keyword: epithelial-mesenchymal interactions,cell fate,expression,tooth,mouse,differentiation tumorigenesis,pathway,growth,gene Please Cite As: SIAR, C. H., NAGATSUKA, H., CHUAH, K. S., RIVERA, R. S., NAKANO, K., NG, K. H. & KAWAKAMI, T. 2010. Notch4 overexpression in ameloblastoma correlates with the solid/multicystic phenotype. Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology, 110, 224-233.

    URL: http://apps.webofknowledge.com search via Accession No >>000280333900015 http://www.scopus.com/inward/record.url?eid=2-s2.077955348096&partnerID=40&md5=8988249a70ac444c1b45ed70f651854b http://www.ncbi.nlm.nih.gov/pubmed/20659700 http://www.sciencedirect.com/science/article/pii/S1079210410001630

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