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  • Squamous Odontogenic Tumor of The Mandible A Case Report Demonstrating Immunoexpression of Notch1, 3, 4, Jagged1 and Delta1

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    University Malaya's Dental Sciences Research
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    This document describes a case report of a 10-year-old girl with a squamous odontogenic tumor (SOT) affecting her anterior mandible. The tumor was treated with local surgical excision and there was no recurrence after 5 years. Histopathological examination revealed the neoplasm was composed of bland-looking squamatoid islands scattered in a mature fibrous connective tissue stroma, consistent with SOT. Immunohistochemical evaluation showed the neoplastic epithelial cells expressed Notch1, Notch3, Notch4, Jagged1 and Delta1 to varying degrees, suggesting these Notch receptors and ligands play differential roles in the cytodifferentiation of SOT.

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    Squamous Odontogenic Tumor of the Mandible a Case Report Demonstrating Immunoexpression of Notch1, 3, 4, Jagged1 and Delta1

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    This document describes a case report of a 10-year-old girl with a squamous odontogenic tumor (SOT) affecting her anterior mandible. The tumor was treated with local surgical excision and there was no recurrence after 5 years. Histopathological examination revealed the neoplasm was composed of bland-looking squamatoid islands scattered in a mature fibrous connective tissue stroma, consistent with SOT. Immunohistochemical evaluation showed the neoplastic epithelial cells expressed Notch1, Notch3, Notch4, Jagged1 and Delta1 to varying degrees, suggesting these Notch receptors and ligands play differential roles in the cytodifferentiation of SOT.

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    7 views2 pages

    Squamous Odontogenic Tumor of The Mandible A Case Report Demonstrating Immunoexpression of Notch1, 3, 4, Jagged1 and Delta1

    Uploaded by

    University Malaya's Dental Sciences Research
    This document describes a case report of a 10-year-old girl with a squamous odontogenic tumor (SOT) affecting her anterior mandible. The tumor was treated with local surgical excision and there was no recurrence after 5 years. Histopathological examination revealed the neoplasm was composed of bland-looking squamatoid islands scattered in a mature fibrous connective tissue stroma, consistent with SOT. Immunohistochemical evaluation showed the neoplastic epithelial cells expressed Notch1, Notch3, Notch4, Jagged1 and Delta1 to varying degrees, suggesting these Notch receptors and ligands play differential roles in the cytodifferentiation of SOT.

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    Download as PDF, TXT or read online from Scribd
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    Squamous odontogenic tumor of the mandible: A case report demonstrating immunoexpression of Notch1, 3, 4, Jagged1 and Delta1 Type: Article

    Abstract: Background: Squamous odontogenic tumor (SOT) is a rare benign odontogenic epithelial neoplasm. A slow-growing painless expansive swelling is the common presenting symptom. Histopathologically, SOT can be easily misdiagnosed as an acanthomatous ameloblastoma. Although Notch receptors and ligands have been shown to play a role in cell fate decisions in ameloblastomas, the role of these cell signaling molecules in SOT is unknown. Case report: This paper describes a case of SOT affecting the anterior mandible of a 10-year-old Indian female. The patient was treated by local surgical excision and there has been no follow-up clinical record of recurrence 5 years after primary treatment. Histopathological examination revealed a solid, locally-infiltrative neoplasm composed of bland-looking squamatoid islands scattered in a mature fibrous connective tissue stroma and the diagnosis was SOT. Immunohistochemical evaluation showed positive reactivity of varying intensity in the neoplastic epithelial cells for Notch, Notch3, Notch4, and their ligands Jagged1 and Delta1. Expression patterns showed considerable overlap. No immunoreactivity was detected for Notch2 and Jagged2. Conclusions: Present findings suggest that Notch receptors and their ligands play differential roles in the cytodifferentiation of SOT.

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    Source ISSN DOI Volume (Issue) Page Year Keyword:

    Siar, C. H. Nakano, K. Ng, K. H. Tomida, M. Nagatsuka, H. Kawakami, T European Journal of Medical Research 0949-2321 15(4) 180-184 2010

    solitary odontogenic tumor,Notch signaling,immunohistochemistry,cytodifferentiation ameloblastomas,neoplasms

    Please Cite As: SIAR, C. H., NAKANO, K., NG, K. H., TOMIDA, M., NAGATSUKA, H. & KAWAKAMI, T. 2010. Squamous odontogenic tumor of the mandible: A case report demonstrating immunoexpression of Notch1, 3, 4, Jagged1 and Delta1 European Journal of Medical Research, 15, 180-184.

    URL: http://apps.webofknowledge.com search via Accession No >>000277831500007 http://www.scopus.com/inward/record.url?eid=2-s2.077952079199&partnerID=40&md5=81cf658f1c9879b886b1e3e02fa73de0 http://www.eurjmedres.com/content/15/4/180 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401003/

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