DRUG GENERIC NAME: Celecoxib

ACTION

INDICATION

CONTRAINDICATION

Physiologic Mechanism Decreased pain and inflammation BRAND NAME: caused by Celebrex arthiritis CLASSIFICATIONS Pharmacologic Therapeutic: Mechanism Anti-rheumatics, Prevention of M NSAIDS Inhibits the Pharmacologic: enzyme COX-2. COX-2 inhibitors This enzyme is required for the synthesis of prostaglandins. DOSAGE: Has analgesic, 400 mg PO antiP.R.N. inflammatory, and antipyretic properties.

Relief of signs and symptoms of osteoarthritis. Relief of signs and symptoms of rheumatoid arthritis in adults.

Hypersensitivity to drug,sulfonamides, or other NSAIDs Severe hepatic impairment History of asthma or urticaria Advance adrenal disease Late pregnancy Breast feeding

ADVERSE EFFECTS/SIDE EFFECTS ADVERSE EFFECTS CNS: dizziness,drowsiness, headache,insomnia,fatigu e CV: Periphera ledema EENT: ophthalmic effects, tinnitus, pharyngitis, rhinitis,sinusitis GI: nausea,diarrhea, constipation, abdominal pain, dyspepsia, flatulence, drymouth, GIbleedingGU: hmenorrhagia Hematologic: Decreased haemoglobin or hematocrit SIDE EFFECTS: -chest pain, weakness, shortness of breath, slurred speech, problems with vision or balance;

NURSING RESPONSIBILITY Assess patients range of motion, degree of swelling, and pain in affected joints before and periodically throughout therapy. Assess patient for allergy to sulfonamides, aspirin, or NSAIDS. Patients with these allergies should not receive celecoxib. May be administered without regard to meals. Instruct patient to take celecoxib exactly as directed. Do not take more than prescribed dose. Increasing doses does not appear to

black, bloody, or tarry stools; coughing up blood or vomit that looks like coffee grounds; swelling or rapid weight

increase effectiveness. Advise patient to notify health care professional promptly if signs or symptoms of GI toxicity (abdominal pain, black stools), skin rash, unexplained weight gain, edema occurs. Patient should discontinue celecoxib and notify health care professional if signs and symptoms of hepatotoxicity (nausea, fatigue, lethargy, pruritus, jaundice, upper right quadrant tenderness, flu-like symptoms) occur.