Trng i hc Khoa hc T nhin Thnh ph H Ch Minh Khoa Ha Chuyn ngnh Ha Hu c

Seminar Ha hc Hu c ng dng 2

NG DNG CA COCAMIDOPROPYL BETAINE TRONG CC SN PHM TY RA V CHM SC C NHN

H v tn sinh vin: Ng Th Chu Ng MSSV: 0914148 Gio vin hng dn: Tn Hong Nm hc: 2012-2013

Mc lc
1. Cht hot ng b mt. 2. Cht hot ng b mt lng tnh (amphoteric). 3. Cocamidopropyl betaine (CAPB). 3.1. Tnh cht. 3.2. Tng hp. 3.3. ng dng. 4. Ti liu tham kho. 3 4 4 4 5 5 7

1. Cht hot ng b mt.

Cht hot ng b mt l cht c kh nng lm gim sc cng b mt ca dung dch[1], c kh nng hp ph ln lp b mt. Cht hot ng b mt phi c ha tan tng i nh. Xt v mt cu trc, cht hot ng b mt c hai phn: phn phn cc (a nc) thng l nhm nh chc hidrat ha mnh, v phn khng phn cc (k nc) l nhm hydrocarbon mch thng hay thm[1]. Khi mt nng nht nh, cc phn t cht hot ng b mt tp hp li vi nhau, u a nc c bao quanh bi cc phn t nc s hng ra ngoi v u k nc t vo bn trong hnh thnh cc Micelle c dng hnh cu, hnh tr hay mng.

cu trc mt ht Micelle
Cht hot ng b mt bao gm: _Cht hot ng b mt t nhin: saponin v phospholipid. _Cht hot ng b mt tng hp[1]: + cht hot ng b mt anionic + cht hot ng b mt cationic
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+ cht hot ng b mt khng ion + cht hot ng b mt lng tnh + cc cht hot ng b mt khc

2. Cht hot ng b mt lng tnh (amphoteric).

Trong phn t cht hot ng b mt lng tnh c c nhm acid ln nhm baz, do ty theo pH ca mi trng m ion c hot tnh mang in tch dng hay m[1]. Trong mi trng acid cc cht ny c hot tnh cation v trong mi trng baz c hot tnh anion. R+NH2CH2CH2COOH mi trng acid R+NH2CH2CH2COOmi trng trung tnh RNH2CH2CH2COOmi trng baz

Cc cht hot ng b mt lng tnh bao gm cc saccosinate, ester betaine, benzimidazol sulfon ha v mt s hp cht khc c th xem nh lng tnh.

3. Cocamidopropyl betaine (CAPB).

Cocamidopropyl betaine (CAPB) l mt cht hot ng b mt lng tnh rt thng c s dng, c cng thc phn t:
O N H N+ O O-

3.1. Tnh cht. _Cocamidopropyl betaine c tnh ty ra cao, n nh, to nh rt tt, bn vi nc cng, to bt tt do s c mt ca nhm carboxyl trong phn t. _ C c tnh lm du da[2] nh kh nng ly du nh, khng lm kh da, khng c, khng gy kch ng da[3].
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_C tc dng tr nm, st trng. _C th kt hp c vi bt k cht hot ng b mt loi khc. _Kh nng t phn hu tt (t 80 n 98%). 3.2. Tng hp. Cocamidopropyl betaine c tng hp qua chui phn ng sau[4]:
O OH
+

NH2

acid lauric

dimethylaminopropylamine
O N H N
+

H2O

O OH N H N
+

Cl O

NaOH

acid chloroacetic
O N H N
+

O+

NaCl

H2 O

cocamidopropyl betaine

3.3. ng dng. Cocamidopropyl betaine thng c s dng trong du gi u, sa tm, kem nh rng, nc ty trang, cc sn phm ty ra gia dng, m phm[5]. Mt s ha m phm thng mi s dng cocamidopropyl betaine:
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Sa tm Palmolive Thermal Spa Massage Thnh phn: Water

Sodium Laureth Copolymer, Sulphate, Betaine, Sodium Cocamidopropyl Butylene/Ethylene Sulfate, Sodium Guar, EDTA,

Violet No. 2 CI 60730, Brilliant Blue FCF CI 42090.

Chloride, Potassium Chloride, Magnesium Bicarbonate,Kaolin, Xanthan Citric Gum, Acid, Hydroxypropyl Tetrasodium

Fragrance, DMDM Hydantoin, PEG-8, Benzophenone-4, Methylchloroisothiazolinone, Methylisothiazolinone, External D & C

Kem nh rng Colgate Max Fresh Cool Mint Thnh phn: sorbitol,
water, hydrated silica, PEG-12, sodium lauryl sulfate, flavor, cellulose gum, sodium tetrasodium cocamidopropyl 1 pyrophosphate, betaine,

saccharin, methylcellulose, FD&C blue no.

Du gi Thi Dng 3 Thnh phn: Aqua, Sodium lauryl ether sulfat,

Ageratum propyl Dimethicon, conyzoides betain, Gleditsia (C ng sc), Eleusine indica (Mn tru), Cocamido PEG-75-lanolin, fera (B kt),

razin,

Tumeric

extract Propyl

(Ngh), paraben,

Guar chlorid, 1,2-

hydroxypropyl Methylparaben,

trimonium

dibromo-2,4-di-cyano butan.

Ocimum grati-ssimum(Hng nhu), Morus alba (Du tm), Glyceryl monostearat, Perfume, 1-acetyl-4-4[[(2RS,4SR)-2(2,4-2-(1H-imidazol-1pipedichlorophe-nyl),

ylmethyl)-1,3-dioxolan-4-yl]phenyl]

Tuy gi thnh cn cao nhng cocamidopropyl betaine t ra y trin vng nh nhng c tnh u vit ca n.

4. Ti liu tham kho.

[1] Disinfection, Sterilization, and Preservation, 5e. Seymour S. Block, Ph.D. 2001. Lippincott Williams & Wilkins. [2] Cocamidopropyl betaine. Jacob, Sharon E., Amini, Sadegh. 2008. American Contact Dermatitis Society. [3] Shaffer, K. K.; Jaimes, J. P.; Hordinsky, M. K.; Zielke, G. R.; Warshaw, E. M. Allergenicity and cross-reactivity of coconut oil derivatives: A double-blind randomized controlled pilot study. 2006. Dermatitis : contact, atopic, occupational, drug : official journal of the American Contact Dermatitis Society, North American Contact Dermatitis Group 17 (2): 7176. PMID 16956456. [4] Foti, C.; Bonamonte, D.; Mascolo, G.; Corcelli, A.; Lobasso, S.; Rigano, L.; Angelini, G. The role of 3-dimethylaminopropylamine and amidoamine in contact allergy to cocamidopropylbetaine. 2003. Contact dermatitis 48 (4): 194198. doi:10.1034/j.1600-0536.2003.00078.x. PMID 12786723.edit. [5] Leidreiter, B. Gruning, D. Kaseborn. Amphoteric surfactants: processing, product composition and properties. H.I.. 2008. International Journal of Cosmetic Science.