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    Pathophysiology of Diabetes Mellitus Type II and Nephrolithiasis

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    diane_manangan
    This document discusses the pathophysiology of type 2 diabetes mellitus and kidney stones. It notes that insulin resistance can be caused by factors like family history, obesity, age, infections, and diet. This leads to decreased insulin production and impaired glucose absorption by cells. Over time, the beta cells become exhausted. High blood glucose then damages blood vessels and kidney filtration, increasing risks of urinary tract infections, electrolyte imbalances, kidney stones, and further diabetes complications.

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    Pathophysiology of Diabetes Mellitus Type II and Nephrolithiasis

    Uploaded by

    diane_manangan
    70 views6 pages
    This document discusses the pathophysiology of type 2 diabetes mellitus and kidney stones. It notes that insulin resistance can be caused by factors like family history, obesity, age, infections, and diet. This leads to decreased insulin production and impaired glucose absorption by cells. Over time, the beta cells become exhausted. High blood glucose then damages blood vessels and kidney filtration, increasing risks of urinary tract infections, electrolyte imbalances, kidney stones, and further diabetes complications.

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    PATHOPHYSIOLOGY.docx

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    This document discusses the pathophysiology of type 2 diabetes mellitus and kidney stones. It notes that insulin resistance can be caused by factors like family history, obesity, age, infections, and diet. This leads to decreased insulin production and impaired glucose absorption by cells. Over time, the beta cells become exhausted. High blood glucose then damages blood vessels and kidney filtration, increasing risks of urinary tract infections, electrolyte imbalances, kidney stones, and further diabetes complications.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as doc, pdf, or txt
    70 views6 pages

    Pathophysiology of Diabetes Mellitus Type II and Nephrolithiasis

    Uploaded by

    diane_manangan
    This document discusses the pathophysiology of type 2 diabetes mellitus and kidney stones. It notes that insulin resistance can be caused by factors like family history, obesity, age, infections, and diet. This leads to decreased insulin production and impaired glucose absorption by cells. Over time, the beta cells become exhausted. High blood glucose then damages blood vessels and kidney filtration, increasing risks of urinary tract infections, electrolyte imbalances, kidney stones, and further diabetes complications.

    Copyright:

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    Download as DOC, PDF, TXT or read online from Scribd
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    of 6

    Pathophysiology of Diabetes Mellitus Type II and Nephrolithiasis Precipitating factors: frequent or chronic infections eating too much sweets

    diet sedentary lifestyle Predisposing factors: 1. family history of DM 2. obesity 3. Age above 40 Insulin resistance

    1. 2. 3. 4.

    Exhaustion of beta cells

    Insulin production/ decrease secretion of insulin Absorption of glucose by the cell Breakdown of fat

    Cell starvation

    Stimulation of hunger mechanism via hypothalamus

    Hunger

    POLYPHAGIA

    HYPERGLYCEMIA

    CBC 333MG/DL

    Kidney filtration mechanism impaired

    Capillary basement membrane thickening

    GLYCOSURIA

    Acidity of urine Diffuse glomerular sclerosis Urethral flora

    Urinary tract infection cause by Urea splitting microorganism increase production of WBC

    UTI

    Circulating blood volume

    POLYURIA & ALBUMINURIA

    Progression of stone to Loop of Henle Accumulation of stones and increasing in size Blood Bessel wall surface Attraction and erosion Stone formation in kidneys Increase size of stones in kidneys Stone matrix progression Multiple urinary calculus

    F & E imbalance

    Hyponatremia

    Hypocalcemia

    Hypoalbuminemia

    Electrolyte imbalances r/t

    hunger

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