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  • Renal Dose Adjust

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    Yamen Zuhair
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    Renal Dose Adjustments of digoxin should be made based on creatinine clearance. For patients with CrCl <10 mL/min, the loading dose should be reduced by 50% and the maintenance dose can be 10-25% of normal or extended to every 48 hours. For patients with CrCl 10-50 mL/min, the total digitalizing dose is 0.5-1 mg given over 3 doses 6 hours apart and the maintenance dose is 25-75% of normal or the normal dose every 36 hours. A maintenance dose of 125 mcg daily or 62.5 mcg for marked renal impairment is recommended. Doses may be increased every 2 weeks and peak body stores should be conservative at

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    Renal dose adjust

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    Renal Dose Adjustments of digoxin should be made based on creatinine clearance. For patients with CrCl <10 mL/min, the loading dose should be reduced by 50% and the maintenance dose can be 10-25% of normal or extended to every 48 hours. For patients with CrCl 10-50 mL/min, the total digitalizing dose is 0.5-1 mg given over 3 doses 6 hours apart and the maintenance dose is 25-75% of normal or the normal dose every 36 hours. A maintenance dose of 125 mcg daily or 62.5 mcg for marked renal impairment is recommended. Doses may be increased every 2 weeks and peak body stores should be conservative at

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    20 views1 page

    Renal Dose Adjust

    Uploaded by

    Yamen Zuhair
    Renal Dose Adjustments of digoxin should be made based on creatinine clearance. For patients with CrCl <10 mL/min, the loading dose should be reduced by 50% and the maintenance dose can be 10-25% of normal or extended to every 48 hours. For patients with CrCl 10-50 mL/min, the total digitalizing dose is 0.5-1 mg given over 3 doses 6 hours apart and the maintenance dose is 25-75% of normal or the normal dose every 36 hours. A maintenance dose of 125 mcg daily or 62.5 mcg for marked renal impairment is recommended. Doses may be increased every 2 weeks and peak body stores should be conservative at

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    Renal Dose Adjustments

    CrCl <10 mL/min: Loading dose: Generally reduced by 50%. Maintenance dose: Can be administered as 10% to 25% of maintenance dose or the interval increased to every 48 hours. CrCl 10 to 50 mL/min: Total digitalizing dose: 0.5 to 1 mg (the initial dose is usually one-half of the total digitalizing dose, followed by 1/4 of the digitalizing dose in each of two subsequent doses at 6 and 12 hour intervals). Maintenance dose: 25% to 75% of the normal daily dose or administer normal dose every 36 hours. In general, a maintenance dose of 125 mcg orally once daily is recommended in patients with impaired renal function, and at a dose of 62.5 mcg is recommended in patients with marked renal impairment. Doses may be increased every 2 weeks according to clinical response. Because of altered digoxin distribution and elimination, projected peak body stores for patients with renal insufficiency should be conservative (i.e., 6 to 10 mcg/kg).

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