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    Acantholytic Acanthoma (Epidermolytic Acanthoma), M 65, Neck

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    Deba P Sarma
    The document describes a 65-year-old male patient with a neck lesion. A biopsy showed compact hyperkeratosis, acanthosis, and papillomatosis. Acantholysis with periperinuclear vacuolization was seen in all epidermal layers except the basal layer. Hypergranulosis was also present with large basophilic granules and eosinophilic bodies. The document further summarizes that acantholytic acanthoma typically presents as a single asymptomatic papule or nodule in elderly males, and has a characteristic histology of acantholytic hyperkeratosis.

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    Acantholytic Acanthoma (Epidermolytic Acanthoma), M 65, Neck

    Uploaded by

    Deba P Sarma
    18 views5 pages
    The document describes a 65-year-old male patient with a neck lesion. A biopsy showed compact hyperkeratosis, acanthosis, and papillomatosis. Acantholysis with periperinuclear vacuolization was seen in all epidermal layers except the basal layer. Hypergranulosis was also present with large basophilic granules and eosinophilic bodies. The document further summarizes that acantholytic acanthoma typically presents as a single asymptomatic papule or nodule in elderly males, and has a characteristic histology of acantholytic hyperkeratosis.

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    Acantholytic Acanthoma (Epidermolytic Acanthoma),M 65, Neck

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    The document describes a 65-year-old male patient with a neck lesion. A biopsy showed compact hyperkeratosis, acanthosis, and papillomatosis. Acantholysis with periperinuclear vacuolization was seen in all epidermal layers except the basal layer. Hypergranulosis was also present with large basophilic granules and eosinophilic bodies. The document further summarizes that acantholytic acanthoma typically presents as a single asymptomatic papule or nodule in elderly males, and has a characteristic histology of acantholytic hyperkeratosis.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Flag for inappropriate content
    18 views5 pages

    Acantholytic Acanthoma (Epidermolytic Acanthoma), M 65, Neck

    Uploaded by

    Deba P Sarma
    The document describes a 65-year-old male patient with a neck lesion. A biopsy showed compact hyperkeratosis, acanthosis, and papillomatosis. Acantholysis with periperinuclear vacuolization was seen in all epidermal layers except the basal layer. Hypergranulosis was also present with large basophilic granules and eosinophilic bodies. The document further summarizes that acantholytic acanthoma typically presents as a single asymptomatic papule or nodule in elderly males, and has a characteristic histology of acantholytic hyperkeratosis.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Flag for inappropriate content
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    Acantholytic acanthoma (Epidermolytic acanthoma)

    Deba P Sarma, MD Omaha

    M 65, neck

    Compact hyperkeratosis, acanthosis, papillomatosis

    Acantholysis with periperinuclear vacuolization involving all layers of the epidermis except the basal layer

    Hypergranulosis with large basophilic keratohyanine granules and intracytoplasmic amorphous eosinophilic bodies

    Acantholytic acanthoma (Epidermolytic acanthoma)


    Single asymptomatic papule or nodule in trunk, arms, neck; genital lesions may be multiple. Age: Elderly (median age 60), M>F

    Benign epidermal tumor with a characteristic histologic picture of acantholytic hyperkeratosis. Compact hyperkeratosis, acanthosis, papillomatosis. Acantholysis with periperinuclear vacuolization involving all layers of the epidermis except the basal layer. Hypergranulosis with large basophilic keratohyanine granules and intracytoplasmic amorphous eosinophilic bodies.

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