Clear cell acanthoma (Pale cell acanthoma)

Deba P Sarma, MD Omaha

M 65, back

Acanthotic epidermis is composed of cells with pale-staining cytoplasm

Parakeratosis with neutrophilic keratitis

Neutrophilic infiltration in the pale lesional squamous cells

Neutrophilic infiltration in the pale lesional squamous cells

Clear cell acanthoma (Pale cell acanthoma)

A benign, slow growing nodular or plaquelike hyperplasia of the epidermis. Location/age: Lower extremities/middle aged and elderly. Histologically, a sharply demarcated epidermal proliferation of glycogen-rich keratinocytes.

Clear cell acanthoma (Pale cell acanthoma)

Acanthotic epidermis is composed of cells with pale-staining cytoplasm. Parakeratosis with neutrophilic keratitis. Lesional epidermis is sharply demarcated from adjacent normal epidermis. Neutrophilic infiltration in the pale lesional squamous cells.