Scribd Logo
Upload

Welcome to Scribd!

  • 2K views

    Polycythemia

    Uploaded by

    Adnan Shahid
    This document summarizes information about polycythemia, including spurious polycythemia, secondary polycythemia due to conditions like hypoxia or kidney lesions, and polycythemia vera. It specifically describes polycythemia vera as a myeloproliferative disorder characterized by overproduction of red blood cells independent of erythropoietin, with 95% of cases associated with a JAK2 mutation. Signs and symptoms include those of hyperviscosity like headaches and dizziness as well as thrombotic complications. Diagnosis involves blood tests showing elevated red blood cell counts and hemoglobin level. Treatment involves phlebotomy and medications like hydroxycarbamide or interferon to

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPT, PDF, TXT or read online from Scribd
    Flag for inappropriate content

    You might also like

    Polycythemia

    Uploaded by

    Adnan Shahid
    2K views9 pages
    This document summarizes information about polycythemia, including spurious polycythemia, secondary polycythemia due to conditions like hypoxia or kidney lesions, and polycythemia vera. It specifically describes polycythemia vera as a myeloproliferative disorder characterized by overproduction of red blood cells independent of erythropoietin, with 95% of cases associated with a JAK2 mutation. Signs and symptoms include those of hyperviscosity like headaches and dizziness as well as thrombotic complications. Diagnosis involves blood tests showing elevated red blood cell counts and hemoglobin level. Treatment involves phlebotomy and medications like hydroxycarbamide or interferon to

    Original Description:

    Polycythemia; Diagnosis & Management

    Original Title

    Polycythemia.ppt

    Copyright

    © Attribution Non-Commercial (BY-NC)

    Available Formats

    PPT, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Report this Document
    This document summarizes information about polycythemia, including spurious polycythemia, secondary polycythemia due to conditions like hypoxia or kidney lesions, and polycythemia vera. It specifically describes polycythemia vera as a myeloproliferative disorder characterized by overproduction of red blood cells independent of erythropoietin, with 95% of cases associated with a JAK2 mutation. Signs and symptoms include those of hyperviscosity like headaches and dizziness as well as thrombotic complications. Diagnosis involves blood tests showing elevated red blood cell counts and hemoglobin level. Treatment involves phlebotomy and medications like hydroxycarbamide or interferon to

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPT, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as ppt, pdf, or txt
    2K views9 pages

    Polycythemia

    Uploaded by

    Adnan Shahid
    This document summarizes information about polycythemia, including spurious polycythemia, secondary polycythemia due to conditions like hypoxia or kidney lesions, and polycythemia vera. It specifically describes polycythemia vera as a myeloproliferative disorder characterized by overproduction of red blood cells independent of erythropoietin, with 95% of cases associated with a JAK2 mutation. Signs and symptoms include those of hyperviscosity like headaches and dizziness as well as thrombotic complications. Diagnosis involves blood tests showing elevated red blood cell counts and hemoglobin level. Treatment involves phlebotomy and medications like hydroxycarbamide or interferon to

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPT, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as ppt, pdf, or txt
    of 9

    POLYCYTHEMIA

    Polycythemia
    Spurious polycythemia (elevated red cell mass
    due to contracted blood volume)

    Secondary polycythemia
    Hypoxia (high altitude, cardiac or pulmonary disease) Carboxyhemoglobin (smoking) Kidney lesions (polycystic kidney disease) Erythropoeitin secreting tumours (hepatoma)

    Polycythemia vera

    Polythemia rubra vera (PRV)


    A myeloproliferative disorder characterised by autonomous overproduction of erythroid cells Erythroid production is independent of erythropoeitin A mutation in JAK2 seen in 95% cases Rare before the age of 40 years Men > Women

    PRV (clinical features)


    Incidental finding Symptoms of hyperviscosity & expanded blood volume
    Lassitude Loss of concentration Headaches Dizziness Blackouts

    PRV (clinical features)


    Symptoms of hyperviscosity & expanded blood volume
    Blurred vision Tinnitus Pruritis after a warm shower Epistaxis

    PRV (clinical features)


    Thrombotic manifestations of ;
    Peripheral arterial disease Coronary artery disease Cerebrovascular accident

    Peptic ulcer Gout SIGNS


    Plethora Splenomegaly

    PRV (diagnosis)
    Complete blood count
    Elevated counts of red cells, white cells & platelets High hemoglobin Elevated hematocrit Normal morphology of blood cells

    Low serum erythropoeitin JAK2 mutation High uric acid

    PRV (Management)
    Venesection
    Prompt relief of hyperviscosity symptoms Usual volume of blood removed is 400-500 mL Repeated every 5-7 days Target hematocrit is 45%

    Aspirin to prevent thrombosis Drugs


    Hydroxycarbamide Interferon

    Radioactive phosphorus

    PRV (Prognosis)
    Median survival in treated patients > 10 years Major causes of morbidity & mortality are cerbrovascular or coronary diseases PRV may convert to another type of myeloproliferative disorder

    You might also like