Overall structure of the GTF2I domain.

(A) Stereoview of a trace of the backbone atoms

for the ensemble of the 20 lowest energy structures (residues 8–93). (B) Ribbon diagram
of the GTF2I domain. A view of the left edge is in the same orientation as in A. As going
to the right, the views are rotated by 90° around the vertical axis, respectively. The
residues forming the core of the protein are shown for the side-chain heavy atoms. (C)
Molecular surface representations of the electrostatic potential (blue, positive; red,
negative) of the GTF2I domain, calculated by MOLMOL. The view is in the same
orientation as those in B and C.