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Pathophysiology BPH Case Study
Pathophysiology BPH Case Study
PATHOPHYSIOLOGY (BPH)
Estrogen
Androgen
RISK FACTORS
Testosterone Become sensitive to growthstimulating hormone
5-alpha reductase
Dihydrosterone
Hyperplasia
Binds to nuclear androgen receptors
Apoptosis
Hyperplasia
Symmetrically enlarged gland
Encroaches upon the bladder neck reducing the ability to funnel in response to micturation
Growth of the socalled median lobe of the prostate extends into the proximal urethra
Size of prostate
UTI Hematuria
OBSTRUCTION
Urethral resistance
Overwhelms the detrusor muscles ability to ensure effective bladder evacuation by micturation
LUTS
Urgency
Nocturia
Detrusor decompensate
Uremia
Peritonitis