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    Diuretic Class Osmotic Action - Create Osmotic Gradient Location - Areas

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    mcwnotes
    There are 5 classes of diuretic drugs that act in different locations along the nephron to increase sodium excretion. Osmotic diuretics act in the proximal tubule by creating an osmotic gradient. Carbonic anhydrase inhibitors act in the proximal tubule by inhibiting carbonic anhydrase. Loop diuretics act in the thick ascending loop of Henle by blocking the sodium-potassium-chloride transporter. Thiazides act in the early distal tubule by blocking the sodium-chloride symporter. Potassium-sparing diuretics act in the late distal tubule and collecting duct by inhibiting sodium reabsorption. Each class increases sodium excretion by a certain

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    Diuretic Class Osmotic Action - Create Osmotic Gradient Location - Areas

    Uploaded by

    mcwnotes
    152 views1 page
    There are 5 classes of diuretic drugs that act in different locations along the nephron to increase sodium excretion. Osmotic diuretics act in the proximal tubule by creating an osmotic gradient. Carbonic anhydrase inhibitors act in the proximal tubule by inhibiting carbonic anhydrase. Loop diuretics act in the thick ascending loop of Henle by blocking the sodium-potassium-chloride transporter. Thiazides act in the early distal tubule by blocking the sodium-chloride symporter. Potassium-sparing diuretics act in the late distal tubule and collecting duct by inhibiting sodium reabsorption. Each class increases sodium excretion by a certain

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    Diuretic Class Osmotic Action -Create Osmotic Gradient Location -Areas

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    There are 5 classes of diuretic drugs that act in different locations along the nephron to increase sodium excretion. Osmotic diuretics act in the proximal tubule by creating an osmotic gradient. Carbonic anhydrase inhibitors act in the proximal tubule by inhibiting carbonic anhydrase. Loop diuretics act in the thick ascending loop of Henle by blocking the sodium-potassium-chloride transporter. Thiazides act in the early distal tubule by blocking the sodium-chloride symporter. Potassium-sparing diuretics act in the late distal tubule and collecting duct by inhibiting sodium reabsorption. Each class increases sodium excretion by a certain

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    152 views1 page

    Diuretic Class Osmotic Action - Create Osmotic Gradient Location - Areas

    Uploaded by

    mcwnotes
    There are 5 classes of diuretic drugs that act in different locations along the nephron to increase sodium excretion. Osmotic diuretics act in the proximal tubule by creating an osmotic gradient. Carbonic anhydrase inhibitors act in the proximal tubule by inhibiting carbonic anhydrase. Loop diuretics act in the thick ascending loop of Henle by blocking the sodium-potassium-chloride transporter. Thiazides act in the early distal tubule by blocking the sodium-chloride symporter. Potassium-sparing diuretics act in the late distal tubule and collecting duct by inhibiting sodium reabsorption. Each class increases sodium excretion by a certain

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    of 1

    Diuretic Action Location ↑ Na Excretion Drugs/ Side Effects

    Class (% Filtered Load) Substances


    Osmotic -Create osmotic -Areas w/ high H20 10 -Mannitol -↑ K excretion
    gradient permeability -Glucose in DM -↑ Bicarb excretion
    -Proximal tubule -Urea in renal -↑ Ca excretion
    -Descending LoH failure
    Carbonic Anhydrase -Inhibit carbonic -Proximal Tubule 5-10 -Acetazolamide -↑ K excretion
    Inhibitors anhydrase (major site) -↑ Bicarb excretion
    ∴ limit activity of -↑ Ca excretion
    Na/H exchanger
    Loop Diuretics -Inhibit Na -Thick ascending Up to 20 -Furosamide -↑ K excretion
    reabsorption via LoH -Bumetanide -↑ Ca excretion
    blocking Na/K/2Cl -Impaired urine
    transporter concentrating and
    -Impairs urine diluting ability
    concentrating and
    diluting ability
    Thiazides -Inhibit Na -Early distal tubule 5-10 -Chlorothiazide -↑ K excretion
    reabsorption via -Metolazone -Impaired urine
    blocking Na-Cl concentrating ability
    symporter in apical
    membrane
    Potassium-Sparing -Inhibit Na -Late distal tubule 3-5 -Aldo antagonists ↓ K excretion
    reabsorption and -Cortical collecting *Spironolactone ↑ Bicarb excretion
    secretion im duct -Na Channel
    principal cells (ENaC) Blockers
    *Amiloride

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