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    Carmen Bartic

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    Micro and nanotechnologies can contribute significantly to progress in neuroscience. They allow the study of cellular communication and signaling at the molecular level through test platforms and high resolution imaging. Example applications include basic neuroscience research on neuronal regeneration and neuroprotection, as well as clinical areas like neuromodulation and assisted neurosurgery. The NERF initiative aims to identify how nanotechnologies can maximize their impact in neuroscience through convergence of neuroelectronics, neurobiology, neuroimaging and other domains in an interdisciplinary approach. Key technologies include multifunctional probes, large sensor and actuator arrays, and closed loop brain-computer interface systems.

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    Carmen Bartic

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    ceysens_patricia
    64 views12 pages
    Micro and nanotechnologies can contribute significantly to progress in neuroscience. They allow the study of cellular communication and signaling at the molecular level through test platforms and high resolution imaging. Example applications include basic neuroscience research on neuronal regeneration and neuroprotection, as well as clinical areas like neuromodulation and assisted neurosurgery. The NERF initiative aims to identify how nanotechnologies can maximize their impact in neuroscience through convergence of neuroelectronics, neurobiology, neuroimaging and other domains in an interdisciplinary approach. Key technologies include multifunctional probes, large sensor and actuator arrays, and closed loop brain-computer interface systems.

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    Micro and nanotechnologies can contribute significantly to progress in neuroscience. They allow the study of cellular communication and signaling at the molecular level through test platforms and high resolution imaging. Example applications include basic neuroscience research on neuronal regeneration and neuroprotection, as well as clinical areas like neuromodulation and assisted neurosurgery. The NERF initiative aims to identify how nanotechnologies can maximize their impact in neuroscience through convergence of neuroelectronics, neurobiology, neuroimaging and other domains in an interdisciplinary approach. Key technologies include multifunctional probes, large sensor and actuator arrays, and closed loop brain-computer interface systems.

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    64 views12 pages

    Carmen Bartic

    Uploaded by

    ceysens_patricia
    Micro and nanotechnologies can contribute significantly to progress in neuroscience. They allow the study of cellular communication and signaling at the molecular level through test platforms and high resolution imaging. Example applications include basic neuroscience research on neuronal regeneration and neuroprotection, as well as clinical areas like neuromodulation and assisted neurosurgery. The NERF initiative aims to identify how nanotechnologies can maximize their impact in neuroscience through convergence of neuroelectronics, neurobiology, neuroimaging and other domains in an interdisciplinary approach. Key technologies include multifunctional probes, large sensor and actuator arrays, and closed loop brain-computer interface systems.

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    of 12

    Micro & NanoTechnologies

    for Neuroscience

    Carmen Bartic, PhD – IMEC


    16-12-2008
    Can micro and nanotechnologies
    contribute to progress
    in Neuroscience?

    HOW?
    MOS transistor

    SYNAPSE
    FU
    NC
    TI
    ON
    AL
    CO 30-50 nm
    NN
    EC
    T IO
    N
    NanoIONICS

    NanoELECTRONICS
    MOS transistor
    5/
    TE ium
    IN nt
    L
    Pe
    APPLICATIONS
    BASIC NEUROSCIENCE CLINICAL
    NEUROSCIENCE
    • Study of cellular
    communication/signaling • Neuronal regeneration
    Ö Test platforms for
    drugs/molecules • Neuroprotection

    • High resolution imaging • Neuromodulation


    Ö Molecular dynamics
    and tracking • High resolution imaging
    Some examples: in vitro
    Some examples: in vivo

    Rat cortical recordings


    NERF Mission
    • Identify potential applications of nanotechnologies in
    neuroscience in order to maximize their impact
    • Implement these technologies and generate progress in
    fundamental brain understanding

    KULeuven/UZ-driven neuro-surgery & medical imaging


    KULeuven/UZ

    APPROACH: Neuro-surgery
    VIB
    Medical Imaging
    Clinical setting
    IMEC-driven neuro-electronics
    VIB-driven neuro-biology
    CONVERGENCE
    & Brain Neuro-
    Computer NERF biology
    INTERDISCIPLINARITY Interface

    IMEC
    XXXX

    UGent/UZ
    UGent-driven JJJ
    Key technologies
    • Micro & Nano multifunctional probes
    » Specific targeting
    » Recording and stimulation at molecular level
    » Imaging
    • Large matrices of sensors & actuators
    » High throughput, network data
    » Function integration
    • Closed loop systems
    » Feedback recording-neuromodulation
    (therapy)
    » Autonomous systems (wireless, telemetry)
    » Algorithms
    » Artifact removal strategies
    In a nutshell
    • Challenges are huge, but the impact could be
    tremendous

    • Interdisciplinarity is key for progress: define


    applications and focus

    • In depth implication of specialists in


    neurobiology, neurology, engineering, material
    sciences towards technology development
    Thank you!
    Questions?

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