Hemoglobin

- Block 9

CU HI TRC NGHIM HEMOGLOBIN 1.Porphin c cu to bi 4 nhn pyrol lin kt vi nhau bi cu ni : A.Mtyl . B.Metylen . C.Disulfua . D.Methenyl . E.Oxy . 2.Cu to Hem gm : A.Porphin, 4 gc V, 2 gc M, 2 gc P, Fe++. B.Porphin, 2 gc E, 4 gc M, 2 gc P, Fe+++ . C.Porphin, 4 gc M, 2 gc V, 2 gc P, Fe++. D.Porphin, 4 gc M, 2 gc V, 2 gc P, Fe+++. E.Porphin, 4 gc M, 2 gc V, 2 gc E, Fe++. 3.Cu to hem gm : A.Porphyrin gn vi gc M, gc P v gc V, B.Protoporphyrin , Fe+++ . C.Protoporphyrin , Fe++. D.Protoporphyrin , Fe++. E.Protoporphyrin , Fe+++. 4.Hb c cu to bi : A.Protoporphyrin , Fe++, globulin. B.Protoporphyrin , Fe++, globin. C.Hem, globulin . D.Protoporphyrin , Fe+++ , globin. E.Protoporphyrin , Fe++ , globin.

Hemoglobin

- Block 9

5.Chn tp hp ng, trong Hb c cu to : 1.Mt hem lin kt vi mt chui polypeptid . 2.Hai hem lin kt vi mt chui polypeptid . 3.Bn hem lin kt vi mt globin . 4.Mt hem lin kt vi bn globin . 5.Bn hem lin kt vi bn chui polypeptid . A.1,2,3 . B.1,3,5 . C.2,4,5 . D.2,3,4 . E.1,4,5 . 6.Globin trong HbA gm : A.2 chui , 2 chui . B.2 chui , 2 chui . C.2 chui , 2 chui . D.2 chui , 2 chui . E.2 chui , 2 chui . 7.Globin trong HbF gm : A.2 chui , 2 chui . B.2 chui , 2 chui . C.2 chui , 2 chui . D.2 chui , 2 chui . E.2 chui , 2 chui . 8.Lin kt hnh thnh gia hem v globin l : A.Lin kt hydro gia Fe++ v nit ca pyrol .

Hemoglobin

- Block 9

B.Lin kt ng ho tr gia Fe++ v nit ca pyrol . C.Lin kt ion gia Fe++ v nit ca imidazol . D.Lin kt phi tr gia Fe++ v nit ca imidazol . E.Lin kt ion gia Fe+++ v nit ca histidin . 9.Oxyhemoglobin c hnh thnh do : A.Gn O2 vo nhn imidazol bi lin kt phi tr . B.O xy ha hem bng O2 . C.Gn O2 vo Fe++ bng lin kt phi tr . D.Gn O2 vo nhn pyrol . E.Gn O2 vo imidazol . 10.O2 gn vi Hb phi th : A.Fe++ Fe+++ . B.Fe++ Fe0. C.Fe++ Fe++ . D.Fe+++ Fe++. E.Fe0 Fe++ . 11.Thnh phn cu trc Hb sp xp theo th t phc tp dn : 1.Pyrol . A.1,2,3,4,5. B.1,3,2,4,5. C.3,2,1,4,5. D.4,5,3,2,1. E.2,3,4,5,1. 12.Hb bnh thng ca ngi trng thnh l : A.HbA, HbA2 . 2.Porphyrin . 3.Porphin . 4.Hem . 5.Hb .

Hemoglobin

- Block 9

B.HbC, HbF. C.HbF, HbS . D.HbC, HbS . E.HbF, HbA2 . 13.Hb b oxy ha to thnh : A.Oxyhemoglobin . B.Carboxyhemoglobin . C.Carbohemoglobin . D.Hematin . E.Methemoglobin . 14.Hb kt hp vi CO : A.Qua nhm amin ca globin . B.Qua nit ca Imidazol . C.Qua nit ca Pyrol . D.Qua nhm Carboxyl ca globin . E.Qua Fe++ca hem . 15.Vai tr ca Hemoglobin trong c th . 1.Kt hp vi CO gii c . 2.Vn chuyn Oxy t phi n t bo . 3.Vn chuyn mt phn CO2 t t bo n phi . 4.Phn hy H2O2 . 5.Oxy ha Fe++ thnh Fe+++ vn chuyn in t . Chn tp hp ng : A.1,2,3 . B.2,3,4 .

Hemoglobin

- Block 9

C.1,3,4 . D.3,4,5 . E.2,3,5 . 16.Hb kt hp vi Oxy khi : A.pCO2 tng, H+ tng, pO2 gim . B.pCO2 gim, H+ tng, pO2 gim . C.pCO2 gim, H+ gim, pO2 tng . D.pCO2 tng, H+ gim, pO2 gim . E.pCO2 gim, H+ gim, pO2 gim . 17.Hb tc dng nh 1 enzym xc tc phn ng : A.Chuyn nhm metyl . B.Chuyn nhm - CHO . C.Phn hy H2O2 . D.Thy phn peptid . E.Thy phn tinh bt .

18.Ngoi Hb, trong c th c cc cht c cu to nhn porphyrin : A.Myoglobin, cytocrom, globulin . B.Peroxydase, catalase, cytocrom . C.Globin, catalase, myoglobin . D.Catalase, oxydase, globulin . E.Peroxydase, diaphorase, globin . 19.Enzym xc tc phn ng chuyn MetHb thnh Hb : A.Peroxydase . B.Catalase .

Hemoglobin

- Block 9

C.Oxydase . D.Diaphorase . E.Reductase . 20.Nguyn liu tng hp Hem : A.Succinyl CoA, glycin, Fe . B.Coenzym A, Alanin, Fe . C.Malonyl CoA, glutamin, Fe . D.Succinyl CoA, serin, Fe . E.Malonyl CoA, Alanin, Fe . 21.Cc giai on tng hp hem : Succinyl CoA +Glycin hem Trnh t sp xp ng : A.1,2,3,4,5,6 . B.1,3,2,4,5,6 . C.1,3,2,5,4,6 . D.1,2,4,3,5,6 . E.1,2,3,5,4,6 . (1) A LA (2) porphobilinogen (3)

Coproporphyrinogen (4)Uroporphyrinogen (5) protoporphyrin (6)

22.Enzym xc tc kt hp protoporphyrin X v Fe++ : A.Ferrochetase . B.ALA Synthetase . C.Dehydratase . D.Decarboxylase .

6

Hemoglobin

- Block 9

E.Oxydase . 23.Hb c tng hp ch yu : A.C, lch, thn . B.Thn, c, ty xng . C.C, lch, hng cu non . D.Thn, no, h vng mc ni m . E.Ty xng, hng cu non . 24.Qu trnh thoi ha Hb mt u bng cch oxy ha m vng prophyrin gia : A.Vng pyrol v C . B.Vng pyrol v C . C.Vng pyrol v C . D.Vng pyrol v V C . E.Vng pyrol v V C . 25.M vng pyrol xc tc bi enzym : A.Hem synthetase . B.Hem decarboxylase . C.Hem oxygenase . D.Ferrochetase . E.Hem reductase . 26.Hb sau khi m vng, tch Fe v globin to thnh : A.Bilirubin . B.Biliverdin . C.Urobilin . D.Stercobilin . E.Urobilinogen

Hemoglobin

- Block 9

27.Cng thc bn di y c tn :
M V O N V M P P M M

A.Biliverdin . B.Bilirubin lin hp. C.Bilirubin t do . D.Verdoglobin . E.Stercobilin . 28.Bilirubin lin hp gm : A.Bilirubin t do lin kt vi albumin . B.Bilirubin t do lin kt vi acid glucuronic . C.Bilirubin t do lin kt vi globin . D.Bilirubin t do lin kt vi globulin . E.Bilirubin t do lin kt vi acid gluconic . 29.Enzym xc tc to bilirubin lin hp : A.Acetyl transferase . B.Carbmyl transferase . C.Amino transferase . D.Glucuronyl transferase . E.Transaldolase . 30.Bilirubin t do c tnh cht :

Hemoglobin

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A.Tan trong nc, cho phn ng diazo chm . B.Tan trong nc, cho phn ng diazo nhanh . C.Khng tan trong nc, cho phn ng diazo chm . D.Tan trong metanol, khng cho phn ng diazo . E.Tan trong te, khng cho phn ng diazo . 31.Bilirubin lin hp thy phn v kh rut cho sn phm khng mu . 1.Mesobilirubin . 2.Mesobilirubinogen . 3.Stercobilinogen . 4.Stercobilin . 5.Bilirubin . Chn tp hp ng : A.1,2 B.2,3 C.4,5 D.1,5 E.3,4 32.Phn thng mu vng do c : A.Bilirubin . B.Biliverdin . C.Stercobilin . D.Urobilin . E.Mesobilirubin . 33.Phn c mu xanh do : 1.Bilirubin khng b kh .

Hemoglobin

- Block 9

2.Vi khun rut gim st . 3.Vi khun rut hot ng mnh . 4.C s hin din ca biliverdin . 5.Stercobilinogen khng oxy ha . Chn tp hp ng : A.1,2,3 B.2,3,4 C.1,2,4 D.1,3,5 E.3,4,5 34.Vng da do tc mt : 1.Bilirubin khng c trong nc tiu. 2.Stercobilin trong phn tng . 3.Bilirubin lin hp tng ch yu trong mu . 4.Bilirubin c trong nc tiu . 5.Urobilin trong nc tiu tng . A.1,2,3 B.1,3,4 C.3,4,5 D.1,4,5 E.2,4,5 35.Cc hemoglobin ngi bnh thng l: A.HbA, HbC, HbF B.HbA, HbF, HbS C.HbA, HbA2, HbF

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Hemoglobin

- Block 9

D.HbD, HbE, HbF E. HbA, HbC, HbD 36.S bt thng v Hb thng do s bt thng trong: A.Chui B.Chui C.Chui hay D.Cu trc protoporphyrin E.Thiu st 37.Trong bnh vng da do dung huyt, trong mu Bilirubin: 1.Ton phn tng 2.Lin hp tng 3.T do tng 4.Lin hp khng tng 5.T do khng tng A.1,4 B.1,5 C.1, 3 D.2,5 E.3,4 38.Trong vng da dung huyt, trong mu ch yu tng: A.Bilirubin lin hp B.Bilirubin t do C.Urobilinogen D.Bilirubin ton phn E.Stecobilinogen

11

Hemoglobin

- Block 9

39.Ngi ta phn bit vng da do dung huyt (vi vng da tt mt) da vo: A.Tng Bilirubin ton phn B.Gim Bilirubin lin hp C.Gim bilirubin t do D.Bilirubin xut hin trong nc tiu E.Bilirubin khng xut hin trong nc tiu 40.Trong vng da do vim gan: A.Tng Bilirubin lin hp B.Gim Bilirubin lin hp C.Tng bilirubin t do D.Gim bilirubin t do E.Tt c cc cu trn u sai

41.Cng thc cu to ca Protoporphyrin IX:

A. M V

M P

M V

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Hemoglobin
B. A P

- Block 9

P A

A P

C. M P

M P

M P

D.

P M

M P

E.

42.Cng thc cu to ca Coproporphyrin I:

A. M V

M P

M V

B.

P A

A P

13

Hemoglobin
C. M P

- Block 9

M P

M P

D.

P M

M P

E.

43.Cng thc thuc thnh phn cu to ca Hem:

A. M V

M P

M V

B.

P A

A P

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Hemoglobin
C. M P

- Block 9

M P

M P

P
D.

P M

M P

E.

44.Khung vit tt ca Porphin:

A. M V

M P

M V

P
B.

P A

A P

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Hemoglobin
C. M P

- Block 9

M P

M P

D.

P M

M P

E.

45.Cng thc cu to ca Uroporphyrin I:

A. M V

M P

M V

B.

P A

A P

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Hemoglobin
C. M P

- Block 9

M P

M P

D.

P M

M P

E.

46.S khc nhau gia hai loi Hb bnh thng ca ngi trng thnh HbA v thi k bo thai HbF ch c mt acid min on xon F ca Hb? A.ng B.Sai 47.S khc nhau gia hai loi Hb bnh thng ca ngi trng thnh HbA v HbA2 ch c mt acid min on xon F ca Hb? A.ng B.Sai 48.S khc nhau gia hai loi bnh thiu mu - Thalassemie v - Thalasesmie l do s bt thng v cc chui v ? A.ng B.Sai

17

Hemoglobin

- Block 9

49.Do CO c i lc vi Hb gp trn 200 ln so vi Oxy nn khi CO kt hp vi Hb nn ngi ta khng c cch g gii c trong trng hp ng c CO ? A.ng B.Sai 50.Cc sn phm chuyn ho ca Hb c mu hay khng c mu l do cc cu ni gia cc vng pyrol b kh hydro hay khng? A.ng B.Sai 51.Sc t mt c to thnh gan, tp trung ti mt, theo ng mt vo rut; mt phn ti hp thu vo mu ri theo tnh mch ca v gan l chu trnh rut gan? A.ng B.Sai 52.Nguyn liu trc tip tng hp Hb l: A.Glycin B.Glycin v succinyl CoA C.Glutamin D.Glutamin v Succinyl CoA E.Tt c cc cu trn u ng 53.Trong hi chng vng da do vim gan: 1.Bilirubin ton phn tng trong mu 2.Bilirubin trc tip tng trong mu 3.Bilirubin gin tip tng trong mu 4.Urobilinogen khng tng trong nc tiu 5.Bilirubin trc tip khng tng trong mu A.1,2,4 B.2,3,4
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Hemoglobin

- Block 9

C1,2,3 D.3,4,5 E.1,4,5 54.Trong vng da do dung huyt: 1.Bilirubin ton phn tng trong mu 2.Bilirubin gin tip khng tng trong mu 3.Bilirubin gin tip tng trong mu 4.Urobilinogen tng trong nc tiu 5.Bilirubin trc tip khng tng trong mu A.1,2,4 B.1,3,4 C1,2,3 D.3,4,5 E.1,4,5 55.Trong vng da do tc mt: 1.Bilirubin ton phn tng trong mu 2.Bilirubin trc tip khng tng trong mu 3.Bilirubin gin tip tng trong mu 4.Sc t mt c trong nc tiu 5.Bilirubin trc tip tng trong mu A.1,2,4 B.1,3,4 C.1,2,3 D.3,4,5 E.1,4,5

19

Hemoglobin

- Block 9

56.Apoferitin l dng st kt hp vi protein? A. ng A. B. Sai 57.Transferrin hay Siderofilin l dng st vn chuyn? A.Sai B.ng 58.Bnh vng da do di truyn v thiu enzym glucuronyl transferase? A.Sai B.ng 59.Trong vng da do tc mt bilirubin trong mu tng ch yu l bilirubin t do? A.ng B.Sai 60.Trong vng da do tc mt bilirubin trong mu tng, xut hin bilirubin t do trong nc tiu do cha lin hp nn d dng qua thn? A.ng B.Sai

p n TNHemoglobin Block 9

1. 2. 3. 4. 5. 6.

D C D B B E

21. 22. 23. 24. 25. 26.

D A E B C B
20

41. 42. 43. 44. 45. 46.

A D A E B A

Hemoglobin

- Block 9

7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20.

B D C C B A E E B C C B D A

27. 28. 29. 30. 31. 32. 33. 34. 35. 36. 37. 38. 39. 40.

C B D C B C C C C B C B D A

47. 48. 49. 50. 51. 52. 53. 54. 55. 56. 57. 58. 59. 60.

B A B A A B C B E A B B B B

21