Pharmacodynamics : Mechanism of drug action

Principles of drug action: The basic type of drug action can be classified as: 1)STIMULATION 2)DEPRESSION 3)IRRITATION 4)REPLACEMENT 5)CYTOTOXIC ACTION Mechanism of drug action Functional proteins that are target of drug action can be divided in two 4 main categories: a)ENZYMES b)ION CHANNELS c) TRANSPORTERS d) RECEPTORS e)NON RECEPTOR MEDIATED : I t includes:- 1) Physical action 2) Chemical action 3) Placebo action

Inhibition of enzymes is a common mode of enzyme action: 1) Non specific inhibition 2) Specific Inhibtion: a) Competitive: it is classified as:- Equillibrium & non equillibrium type b) Non competitive Difference b/w affinity & efficacy? Transducer Mechanisms:- It includes: a)G- Protein coupled receptor: 1) adenyl cyclase 2)Phospholipase C 3)Channel regulation b)Enzyme linked c)Receptors with intrinsic ion channel d)Receptors regulating gene regulation Regulation of receptors:- It includes: a)Desensitization of receptors

b)Supersensitivity of receptors c)Up regulation of receptors d)Down regulation of receptors Functions of receptors Drug dose relationship Combined effects of drug:- It includes: a)SYNERGISM 1)Additive 2) Supraadditive b)ANTAGONISM 1) Competitiveequilibrium &non equilibrium type 2) Non competitive