Canadian Scientist Phil Gold Contact Information Background Information: Born: September 17, 1936 Clinical Research Centre

re Born in: Montral, Quebec 1650 Av Cedar Bureau D13 173 Attained his primary and secondary schooling in Montreal Montreal, QC H3G 1A4, Canada Went to McGill University obtained 4 degrees (514) 934-1934 o B.Sc. in Honors Physiology - 1957 o M.D.C.M. and an M.Sc. Degree in Physiology 1961 1963 1965: labs of the McGill University Medical Clinic of The Montreal General Hospital obtaining Ph.D. Degree 1st Director of McGill Cancer Centre Ranked: o Associate Professorship o Full Professor of Medicine and Physiology (1972) 1980 returned to The Montreal General Hospital as Physician-in-Chief o 1985 1990 Chairman of the Department of Medicine at McGill University 1995 became Executive Director of the Clinical Research Centre of the Research Institute of the McGill University Health Centre 1960 - Married to Evelyn Katz Has 3 children: Ian, Josie, and Joel Has 6 grandchildren: Zachary, Michael, Alexander, Benjamin, Adam, and Matthew Honours : Received from McGill: o BSc 1957 o MSc 1961 o PhD 1965 Gairdner Award, 1978 Manning Award, 1982 F.N.G Starr Award of the Canadian Medical Association, 1983 Izaak Walton Killam Award, 1985 Companion of the Order of Canada, 1986 Officer of the Order of Quebec, 1990 Research Samuel Freedman and Phil Gold discovered: o Carcinoembryonic antigen (CEA) Produced during growth of digestive cancer cells Produced in: Tumors Fetal embryonic gut Pancreas Figure 1 - Phil Gold Liver cells CEA test helpful in evaluating the amount of cancer, its growth rate and response treatment CEA gene was recently cloned Recently developed technology of molecular biology and genetics helped o define the complete gene structure for the CEA o Family of the CEA form a sub-group of the immunoglobulin superfamily o CEA family serves as Cell Adhesion Materials (CAMs) or Cadherins Radioimmunoassay of CEA used for: o Human cancer marker (various forms) o Detecting human tumor growth o Monitoring of patients post-operatively for radioimmunolocalization of tumors o Immunohistochemistry o Immunocytochemistry Recent experiments: o Eradicate tumors through monoclonal anti CEA o Immunize patients against CEA by immunizing with CEA gene, added to the vaccine virus