ACR Criteria for the classification of systemic lupus erythematosus

1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. Malar rash Discoid rash Photosensitivity Oral ulcers Arthritis Serositis Renal disorder Neurologic disorder Hematologic disorder Immunologic disorder Antinuclear Antibody

Any of four or more criteria should be present, serially or simultaneously.

The 1997 Revised Criteria for the Classification of SLE

1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. Malar rash Discoid rash Photosensitivity Oral ulcers Arthritis Serositis Renal disorder Neurologic disorder Hematologic disorder Immunologic disorder Antinuclear Antibody
a) b) c) Anti-DNA or Anti-Sm or Positive finding of antiphospholipid antibodies based on: 1 An abnormal serum level of IgG or IgM anticardiolipin antibodies or 2 A positive test result for lupus anticoagluant using a standard method or 3 A false positive serologic test for syphilis, known to be positive for at least 6 months

ACR-Criteria: Prevalence in course of disease

1 2 3 4 5 6a 6b 7a 7b 8a 8b 9a 9b 9c 9d 10a 10b 10c 11 Prevalence in course of disease [%] Malar rash 50 Discoid rash 10 - 30 Photosensitivity 15 - 40 Oral and nasopharyngeal ulcers 15 - 25 Arthritis, not erosive 90 Pleuritis 50 - 60 Pericarditis 20 - 25 Persistent proteinuria > 0,5 g/die 50 - 70 Zylindrurie (erythrocyte, granule) 30 - 40 Neurobiological manifestations; cramps 10 Psychosis 15 Hemolytic anemia with reticulocytosis 10 Leukocytopenia < 4000 /m 40 - 50 Lymphocytopenia <1500 /m 60 - 80 Thrombocytopenia <100.000 /m 20 - 30 dsDNA antibodies 60 - 90 sm antibodies 10 - 30 Cardiolipin antibodies Antinuclear antibodies >95