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  • Resume Rumus

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    Hananun Zharfa
    146 views4 pages
    The document discusses pharmacokinetic parameters for several drugs, including aminoglycosides, digoxin, phenobarbital, and theophylline. It provides information on therapeutic ranges, plasma concentrations, clearance rates in children and adults, half-lives, volume of distribution that varies based on factors like age, weight, and obesity. It also discusses dosing calculations and equations for determining loading doses, maintenance doses, and steady state plasma concentrations.

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    Resume Rumus

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    The document discusses pharmacokinetic parameters for several drugs, including aminoglycosides, digoxin, phenobarbital, and theophylline. It provides information on therapeutic ranges, plasma concentrations, clearance rates in children and adults, half-lives, volume of distribution that varies based on factors like age, weight, and obesity. It also discusses dosing calculations and equations for determining loading doses, maintenance doses, and steady state plasma concentrations.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as XLS, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as xls, pdf, or txt
    146 views4 pages

    Resume Rumus

    Uploaded by

    Hananun Zharfa
    The document discusses pharmacokinetic parameters for several drugs, including aminoglycosides, digoxin, phenobarbital, and theophylline. It provides information on therapeutic ranges, plasma concentrations, clearance rates in children and adults, half-lives, volume of distribution that varies based on factors like age, weight, and obesity. It also discusses dosing calculations and equations for determining loading doses, maintenance doses, and steady state plasma concentrations.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as XLS, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as xls, pdf, or txt
    of 4

    Rumus Cp maks Cp min C toksik

    Aminoglikosida 4-8 mg/L (pd pneumonia 8 mg/L) < 2 mg/L > 4 mg/L selama > 10 hari

    Digoksin

    Phenobarbital

    Terapeutic range : 0,8 2 g/L F tablet :0,7., elixir 0,8., soft gelatin 1. S=1

    Therapeutic plasma concentration : 10-30 mg/L F; > 0.9 ; S ( for Na Salt) 0,9

    ClCr cl (ml/min)

    [ (140-umur) x BB] / (Sr x 72) (0,8 mL/kg/min) + (Clcr dl ml/min) Cl anak 8 mL/kg/jam (0,2 L/kg/hari) ; Cl dws 4 mL/kg/jam (0,1 L/kg/hari)x BB kg t1/2 anak : 2,5 Hari ; dewasa 5 hari Kd = Cl/Vd 7,3 L/kg

    Cl total CHF Ke/K t 1/2 0,00293 x ClCr + 0,014 0,693 / Ke

    (0,33 ml/kg/min) (berat dl kg) + (0,9)(Clcr dl ml/min)

    Vd

    0,25 L/kg BB

    0,6-0,7 L/kg (3,8)(berat dl kg) + (3,1)(ClCr dl ml/mnt)

    Vd Obes IBW laki IBW per

    (0,25 L/kg)(IBW) +0,1(TBW-IBW)

    (0,25 L/kg)(IBW) +0,4(TBW-IBW)


    50 +0,92 (TB-150 cm) 45 + 0,92 (TB-150 cm) 45 + 2,3 (TB dlm inc 60) 1 inc = 2,54 cm

    Morbidly Obese Vd Asites

    BB = IBW + 0,4 (TBW-IBW) (0,25 L/kg x IBW) +0,1 (kelebihan BB + vol udem)

    Vd anak <5th Interval pemberian Dosis yng diinginkan Ko Dosis Loading

    ( 0,5 L/kg ( usia/5 x 0,25) x BB

    Cmaks, ss x Ke x Vd [(1-e

    -ket

    ) /(1-e

    -ket

    )]

    Cmaks ss x Vd

    ko/(1-e-ket)

    maintance dose

    ko/

    Jml obat yg diabs = F x dosis

    Cp ss ave = Cp ss min

    Theofilin

    Fak penghambat = perokok x SOPD x CHF CL = Faktor penghambat x Vd

    Vd = 0,4 L/kg/jam x BBkg

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