HME

Guide: Prof. R. N. Saha Presented by: Satish Reddi

Report on BASF Workshop (Hot Melt Extrusion)

Introduction
Hot melt extrusion (HME) technology itself can be defined as process where a material which melt or softens at elevated temperature and pressure is forced through an orifice by screw. Since 1930, it has been used in plastic and food industry. In the 1980s, BASF SE was the first to apply this process for pharmaceutical using PVPs.

Steps involved in HME

Step 1: Feeding of extruder

Step 2: Step 3: Flow of mass through die

Step 4: Downstream processing

Schematic representation of twin screw extruder

Component parts of single screw extruder

Screw and kneading elements

Process parameters in HME

Zone and die temperature

Screw speed
Torque and power consumption Pressure

Melt viscosity
Feed rate

References:
1. Kolter K., Nalawade S., Rottmann N. Hot-Melt Extrusion with BASF

Pharma Polymers : Extrusion compendium. 2nd edition June 2011

by BASF SE, Germany. 2. Breitenbach J. Melt extrusion: from process to drug delivery

technology. European Journal of pharmaceutics and Biopharmaceutics.

54 (2002) 107 117. 3. Grassi M. et al. Preparation of sustained release co-extrudates by hot-melt extrusion and mathematical modelling of in vitro/in vivo release profiles. European Journal of Pharmaceutical Sciences. 33 (2008) 282 293.

References:
4. Gandhi R., Kaul C., Panchgula R. Extrusion spheronization in the development of oral controlled release dosage form. Pharmaceutical Science and Technology Today. 1999, 2 (4): 160-170. 5. Ghebre-Sellassie I. Pellets: A general overview, Ghebre-Sellassie I. (Ed.), Pharmaceutical pelletization technology, Marcel Dekker Inc., New York and Basel. 1989, 1-13. 6. Dukic-Ott A. Production of pellets via extrusionspheronization without the incorporation of microcrystalline cellulose: A critical review. European Journal of Pharmaceutics and Biopharmaceutics. 2009, 71: 38-46

Thank You