Cannabis (Drug) - Wikipedia, The Free Encyclopedia

Cannabis (drug) - Wikipedia, the free encyclopedia
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Cannabis (drug)
From Wikipedia, the free encyclopedia
(Redirected from Marijuana) Cannabis, also known as marijuana[1] (from the Mexican Spanish marihuana), and by other names,a[] is a preparation of the Cannabis plant intended for use as a psychoactive drug and as medicine.[2][3][4] Pharmacologically, the principal psychoactive constituent of cannabis is tetrahydrocannabinol (THC); it is one of 400 compounds in the plant, including other cannabinoids, such as cannabidiol (CBD), cannabinol (CBN), and tetrahydrocannabivarin (THCV).[5] Contemporary uses of cannabis are as a recreational drug, as religious or spiritual rites, or as medicine; the earliest recorded uses date from the 3rd millennium BC.[6] In 2004, the United Nations estimated that global consumption of cannabis indicated that approximately 4.0 percent of the adult world population (162 million people) used cannabis annually, and that approximately 0.6 percent (22.5 million) of people used cannabis daily.[7] Since the early 20th century cannabis has been subject to legal restrictions with the possession, use, and sale of cannabis preparations containing psychoactive cannabinoids currently illegal in most countries of the world; the United Nations has said that cannabis is the most-used illicit drug in the world.[8][9]
Dried flowers of the Cannabis sativa plant with visible trichomes.
Contents
1 Effects 1.1 Classification 1.2 Medical use 1.3 Long-term effects 2 Forms 2.1 Unprocessed 2.2 Processed 2.2.1 Kief 2.2.2 Hashish 2.2.3 Hash oil 2.2.4 Residue (resin) 3 Routes of administration 4 Mechanism of action 5 Potency 5.1 Difference between Cannabis indica and Cannabis sativa 5.2 Adulterants 6 Detection of use
People of the Hadza ethnic group in north-central Tanzania smoking cannabis
http://en.wikipedia.org/wiki/Marijuana
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7 Gateway drug theory 8 History 9 Legal status 10 Price 11 Truth serum 12 Breeding and cultivation 13 In arts and literature 14 See also 15 Footnotes 16 Citations 17 Further reading 18 External links
Effects
Main article: Effects of cannabis Cannabis has psychoactive and physiological effects when consumed. The minimum amount of THC required to have a perceptible psychoactive effect is about 10 micrograms per kilogram of body weight.[10] Aside from a subjective change in perception and, most notably, mood, the most common short-term physical and neurological effects include increased heart rate, increased appetite and consumption of food,[11] lowered blood pressure, impairment of short-term and working memory,[12] psychomotor coordination, and concentration. Long-term effects are less clear.[13][14] Deaths attributed directly to cannabis usage are infrequent but have been documented.[15][16][17][18] Recorded fatalities resulting from cannabis overdose in animals are generally only after intravenous injection of hashish oil.[19]
Classification
Main article: Psychoactive effects
Main short-term physical effects of cannabis
While many psychoactive drugs clearly fall into the category of either stimulant, depressant, or hallucinogen, cannabis exhibits a mix of all properties, perhaps leaning the most towards hallucinogenic or psychedelic properties, though with other effects quite pronounced as well. THC is typically considered the primary active component of the cannabis plant, various scientific studies have suggested that certain other cannabinoids like CBD may also play a significant role in its psychoactive effects.[20][21][22]
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Medical use
Main article: Medical cannabis Cannabis used medically has several well-documented beneficial effects. Among these are: the amelioration of nausea and vomiting, stimulation of hunger in chemotherapy and AIDS patients, lowered intraocular eye pressure (shown to be effective for treating glaucoma), as well as general analgesic effects (pain reliever).b[]
Prescription medical cannabis in the Netherlands
Less confirmed individual studies also have been conducted indicating cannabis to be beneficial to a gamut of conditions running from multiple sclerosis to depression. Synthesized cannabinoids are also sold as prescription drugs, including Marinol (dronabinol in the United States and Germany) and Cesamet (nabilone in Canada, Mexico, the United States and the United Kingdom).b[] Currently, the U.S. Food and Drug Administration (FDA) has not approved smoked cannabis for any condition or disease in the United States, largely because the FDA claims good quality scientific evidence for its use from U.S. studies is lacking.[23] Sixteen states have legalized cannabis for medical use.[24][25] The United States Supreme Court has ruled in United States v. Oakland Cannabis Buyers' Coop and Gonzales v. Raich that it is the federal government that has the right to regulate and criminalize cannabis, even for medical purposes. Canada, Spain, The Netherlands and Austria have legalized some form of cannabis for medicinal use.[26]
Long-term effects
Main article: Long-term effects of cannabis See also: Cannabis smoking Cannabis can be habit-forming and the development of cannabis dependence in some users has been well established; its effects on intelligence,[28] memory, respiratory functions and the possible relationship of cannabis use to mental disorders[29] such as schizophrenia,[30] psychosis,[31] depersonalization disorder[32] and depression[33] are still under discussion. A study published in the American Journal of Epidemiology in 2011, concluded that the prevalence of obesity is lower in cannabis users than in nonusers.[34] A 35-year study published August 2012 in Proceedings of the National Academy of Sciences and funded partly by NIDA and other NIH institutes provides objective evidence that, at least for adolescents, marijuana is harmful to the brain.[28] It
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was found that the persistent, dependent use of marijuana before age 18 showed lasting harm to a person's intelligence, attention and memory. Quitting cannabis did not appear to reverse the loss. However, individuals who started cannabis use after the age of 18 did not show similar declines.[35]
Cannabis is ranked one of the least harmful drugs by a study published in the UK medical journal, The Lancet.[27]
A July 2012 report in Brain reveals neural-connectivity impairment in some brain regions following prolonged cannabis use initiated in adolescence or young adulthood.[36]
Forms
Unprocessed
The terms cannabis or marijuana generally refer to the dried flowers and subtending leaves and stems of the female cannabis plant.[citation needed] This is the most widely consumed form, containing 3% to 22% THC.[37][38] In contrast, cannabis varieties used to produce industrial hemp contain less than 1% THC and are thus not valued for recreational use.[39]
Processed
Kief Main article: Kief Kief is a powder, rich in trichomes, which can be sifted from the leaves and flowers of cannabis plants and either consumed in powder form or compressed to produce cakes of hashish.[40] Hashish Main article: Hashish Hashish (also spelled hasheesh, hashisha, or simply hash) is a concentrated resin produced from the flowers of the female cannabis plant. Hash can often be more potent than marijuana and can be smoked or chewed.[41] It varies in color from black to golden brown depending upon purity. Hash oil Main article: Hash oil
Hashish Dried Cannabis flowers in natural herbal form
Hash oil, or "butane honey oil" (BHO), is a mix of essential oils and resins extracted from mature cannabis foliage through the use of various solvents. It has a high proportion of cannabinoids (ranging from 40 to 90%)[42] and is used in a variety of cannabis foods.
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Residue (resin) Because of THC's adhesive properties, a sticky residue, most commonly known as "resin", builds up inside utensils used to smoke cannabis. It has tar-like properties but still contains THC as well as other cannabinoids. This buildup retains some of the psychoactive properties of cannabis but is more difficult to smoke without discomfort caused to the throat and lungs. This BHO tar may also contain CBN, which is a breakdown product of THC. Cannabis users typically only smoke residue when cannabis is unavailable. Glass pipes may be water-steamed at a low temperature prior to scraping in order to make the residue easier to remove.[43]
Routes of administration
Main article: Cannabis consumption Cannabis is consumed in many different ways, most of which involve inhaling vaporized cannabinoids ("smoke") from small pipes, bongs (portable version of hookah with water chamber), paper-wrapped joints or tobacco-leaf-wrapped blunts. A vaporizer heats herbal cannabis to 365410 F (185210 C),[citation needed] causing the active ingredients to evaporate into a vapor without burning the plant material (the boiling point of THC is 390.4 F (199.1 C) at 760 mmHg pressure).[44] A lower proportion of toxic chemicals is released than by smoking, depending on the design of the vaporizer and the temperature setting. This method of consuming cannabis produces markedly different effects than smoking due to the flash points of different cannabinoids; for example, CBN (usually considered undesirable) has a flash point of 212.7 C (414.9 F)[45] and would normally be present in smoke but not in vapor. Fresh, non-dried cannabis may be consumed orally. However, the cannabis or its extract must be sufficiently heated or dehydrated to cause decarboxylation of its most abundant cannabinoid, tetrahydrocannabinolic acid (THCA), into psychoactive THC.[46] Cannabinoids can be extracted from cannabis plant matter using high-proof spirits (often grain alcohol) to create a tincture, often referred to as Green Dragon. Cannabis can also be consumed as a tea. THC is lipophilic and only slightly watersoluble (with a solubility of 2.8 mg per liter),[47] so tea is made by first adding a saturated fat to hot water (i.e. cream or any milk except skim) with a small amount of cannabis.
A forced-air vaporizer. The detachable balloon (top) fills with vapors that are then inhaled.
A joint
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Mechanism of action
The high lipid-solubility of cannabinoids results in their persisting in the body for long periods of time. Even after a single administration of THC, detectable levels of THC can be found in the body for weeks or longer (depending on the amount administered and the sensitivity of the assessment method). A number of investigators have suggested that this is an important factor in marijuana's effects, perhaps because cannabinoids may accumulate in the body, particularly in the lipid membranes of neurons.[48]
Until recently, little was known about the specific mechanisms of action of THC at the neuronal level. However, researchers have now confirmed that THC exerts its most prominent effects via its actions on two types of cannabinoid receptors, the CB1 receptor and the CB2 receptor, both of which are G-Protein coupled receptors. The CB1 receptor is found primarily in the brain as well as in some peripheral tissues, and the CB2 receptor is found primarily in peripheral tissues, but is also expressed in neuroglial cells as well.[49] THC appears to alter mood and cognition through its agonist actions on the CB1 receptors, which inhibit a secondary messenger system (adenylate cyclase) in a dose dependent manner. These actions can be blocked by the selective CB1 receptor antagonist SR141716A (rimonabant), which has been shown in clinical trials to be an effective treatment for smoking cessation, weight loss, and as a means of controlling or reducing metabolic syndrome risk factors.[50] However, due to the dysphoric effect of CB1 antagonists, this drug is often discontinued due to these side effects.
A conduction vaporizer, with flexible extension tube ("whip"). A small serving of cannabis is heated on a metal platform (center).
Via CB1 activation, THC indirectly increases dopamine release and produces psychotropic effects. THC, anandamide, and several other cannabinoids also act as allosteric modulators of opioid and glycine receptors. The role of these interactions in the "marijuana high" remains elusive.[citation needed]
Potency
According to the United Nations Office on Drugs and Crime (UNODC), "the amount of THC present in a cannabis sample is generally used as a measure of cannabis potency."[51] The three main forms of cannabis products are the flower, resin (hashish), and oil (hash oil). The UNODC states that cannabis often contains 5% THC content, resin "can contain up to 20% THC content", and that "Cannabis oil may contain more than 60% THC content."[51] A scientific study published in 2000 in the Journal of Forensic Sciences (JFS) found that the potency (THC content) of confiscated cannabis in the United States (US) rose from "approximately 3.3% in 1983 and 1984", to "4.47% in 1997". It also concluded that "other major cannabinoids (i.e., CBD, CBN, and CBC)" (other chemicals in cannabis) "showed no significant change in their concentration over the years".[52] More recent research undertaken at the University of Mississippi's Potency Monitoring Project[53] has found that average THC levels in cannabis samples between 1975 and 2007 have increased from 4% in 1983 to 9.6% in 2007.
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Australia's National Cannabis Prevention and Information Centre (NCPIC) states that the buds (flowers) of the female cannabis plant contain the highest concentration of THC, followed by the leaves. The stalks and seeds have "much lower THC levels".[54] The UN states that the leaves can contain ten times less THC than the buds, and the stalks one hundred times less THC.[51] After revisions to cannabis rescheduling in the UK, the government moved cannabis back from a class C to a class B drug. A purported reason was the appearance of high potency cannabis. They believe skunk accounts for between 70 and 80% of samples seized by police[55] (despite the fact that skunk can sometimes be incorrectly mistaken for all types of herbal cannabis).[56][57] Extracts such as hashish and hash oil typically contain more THC than high potency cannabis flowers. While commentators have warned that greater cannabis "strength" could represent a health risk, others have noted that users readily learn to compensate by reducing their dosage, thus benefiting from reductions in smoking side-hazards such as heat shock or carbon monoxide. A number of analytical laboratories serving the medical marijuana industry in the Western US have evaluated THC levels of medical cannabis. Typical levels range between 1617% while cannabis materials with less than 10% THC are an anomaly. Currently upper THC limits for herbal cannabis grown in California are 2325%.[58]
Difference between Cannabis indica and Cannabis sativa

Cannabis indica may have a CBD:THC ratio 45 times that of Cannabis sativa. Cannabis strains with relatively high CBD:THC ratios are less likely to induce anxiety than vice versa. This may be due to CBD's antagonistic effects at the cannabinoid receptors, compared to THC's partial agonist effect. CBD is also a 5-HT1A receptor agonist, which may also contribute to an anxiolytic effect.[59] This likely means the high concentrations of CBD found in Cannabis indica mitigate the anxiogenic effect of THC significantly.[59] The effects of sativa are well known for its cerebral high, hence used daytime as medical cannabis, while indica are well known for its sedative effects and preferred night time as medical cannabis.[59]
Adulterants
Chalk (in the Netherlands) and glass particles (in the UK) have been used to make cannabis appear to be higher quality.[60][61][62] Types of Cannabis Increasing the weight of hashish products in Germany with lead [63] caused lead intoxication in at least 29 users. In the Netherlands two chemical analogs of sildenafil (Viagra) were found in adulterated marijuana.[64]
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According to both the "Talk to FRANK" website and the UKCIA website, Soap Bar, "perhaps the most common type of hash in the UK", was found "at worst" to contain turpentine, tranquilizers, boot polish, henna and animal fecesamongst several other things.[65][66] One small study of five "soap-bar" samples seized by UK Customs in 2001 found huge adulteration by many toxic substances, including soil, glue, engine oil and animal feces.[67]
Detection of use
Main article: Cannabis drug testing THC and its major (inactive) metabolite, THC-COOH, can be measured in blood, urine, hair, oral fluid or sweat using chromatographic techniques as part of a drug use testing program or a forensic investigation of a traffic or other criminal offense. The concentrations obtained from such analyses can often be helpful in distinguishing active use from passive exposure, elapsed time since use, and extent or duration of use. These tests cannot, however, distinguish authorized cannabis smoking for medical purposes from unauthorized recreational smoking.[68] Commercial cannabinoid immunoassays, often employed as the initial screening method when testing physiological specimens for marijuana presence, have different degrees of cross-reactivity with THC and its metabolites. Urine contains predominantly THC-COOH, while hair, oral fluid and sweat contain primarily THC. Blood may contain both substances, with the relative amounts dependent on the recency and extent of usage.[68][69][70][71] The Duquenois-Levine test is commonly used as a screening test in the field, but it cannot definitively confirm the presence of cannabis, as a large range of substances have been shown to give false positives. Despite this, it is common in the United States for prosecutors to seek plea bargains on the basis of positive D-L tests, claiming them definitive, or even to seek conviction without the use of gas chromatography confirmation, which can only be done in the lab.[72] In 2011, researchers at John Jay College of Criminal Justice reported that dietary zinc supplements can mask the presence of THC and other drugs in urine. Similar claims have been made in web forums on that topic.[73]
Gateway drug theory

Further information: Gateway drug theory Since the 1950s, United States drug policies have been guided by the assumption that trying cannabis increases the probability that users will eventually use "harder" drugs.[74] This hypothesis has been one of the central pillars of anti-cannabis drug policy in the United States,[75] though the validity and implications of this hypothesis are hotly debated.[74] Studies have shown that tobacco smoking is a better predictor of concurrent illicit hard drug use than smoking cannabis.[76] No widely accepted study has ever demonstrated a cause-and-effect relationship between the use of cannabis and the later use of harder drugs like heroin and cocaine. However, the prevalence of tobacco cigarette advertising and the practice of mixing tobacco and cannabis together in a single large joint, common in Europe, are believed to be cofactors in promoting nicotine dependency among young people trying cannabis.[77]
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A 2005 comprehensive review of the literature on the cannabis gateway hypothesis found that preexisting traits may predispose users to addiction in general, the availability of multiple drugs in a given setting confounds predictive patterns in their usage, and drug sub-cultures are more influential than cannabis itself. The study called for further research on "social context, individual characteristics, and drug effects" to discover the actual relationships between cannabis and the use of other drugs.[78] Some studies state that while there is no proof for this gateway hypothesis, young cannabis users should still be considered as a risk group for intervention programs.[79] Other findings indicate that hard drug users are likely to be "poly-drug" users, and that interventions must address the use of multiple drugs instead of a single hard drug.[80] Another gateway hypothesis is that a gateway effect may be detected as a result of the "common factors" involved with using any illegal drug. Because of its illegal status, cannabis users are more likely to be in situations which allow them to become acquainted with people who use and sell other illegal drugs. [81][82] By this argument, some studies have shown that alcohol and tobacco may be regarded as gateway [76] drugs. However, a more parsimonious explanation could be that cannabis is simply more readily available (and at an earlier age) than illegal hard drugs, and alcohol/tobacco are in turn easier to obtain earlier than cannabis (though the reverse may be true in some areas), thus leading to the "gateway sequence" in those people who are most likely to experiment with any drug offered.[74] A 2010 study published in the Journal of Health and Social Behavior found that the main factors in users moving on to other drugs were age, wealth, unemployment status, and psychological stress. The study found there is no "gateway theory" and that drug use is more closely tied to a person's life situation, although cannabis users are more likely to use other drugs.[83]
History
See also: Cannabis, Hemp, War on Drugs, and Legal history of cannabis in the United States Cannabis is indigenous to Central and South Asia.[86] Evidence of the inhalation of cannabis smoke can be found in the 3rd millennium BCE, as indicated by charred cannabis seeds found in a ritual brazier at an ancient burial site in present day Romania.[6] In 2003, a leather basket filled with cannabis leaf fragments and seeds was found next to a 2,500- to 2,800-year-old mummified shaman in the northwestern Xinjiang Uygur Autonomous Region of China.[87][88] Cannabis is also known to have been used by the ancient Hindus of India and Nepal thousands of years ago. The herb was called ganjika in Sanskrit (/ ganja in modern Indic languages).[89][90] The ancient drug soma, mentioned in the Vedas, was sometimes associated with cannabis.[91] Cannabis was also known to the ancient Assyrians, who discovered its psychoactive properties through the Aryans.[92] Using it in some religious ceremonies, they called it qunubu (meaning "way to produce smoke"), a probable origin of the modern word "cannabis".[93] Cannabis was also
The use of cannabis, at least as fiber, has been shown to go back at least 10,000 years in Taiwan.[84] M (), the Chinese expression for hemp, is a pictograph of two plants under a shelter.[85]
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introduced by the Aryans to the Scythians, Thracians and Dacians, whose shamans (the kapnobatai "those who walk on smoke/clouds") burned cannabis flowers to induce a state of trance.[94] Cannabis has an ancient history of ritual use and is found in pharmacological cults around the world. Hemp seeds discovered by archaeologists at Pazyryk suggest early ceremonial practices like eating by the Scythians occurred during the 5th to 2nd century BCE, confirming previous historical reports by Herodotus.[95] One writer has claimed that cannabis was used as a religious sacrament by ancient Jews and early Christians[96][97] due to the similarity between the Hebrew word "qannabbos" ("cannabis") and the Hebrew phrase "qen bsem" ("aromatic cane"). It was used by Muslims in various Sufi orders as early as the Mamluk period, for example by the Qalandars.[98] A study published in the South African Journal of Science showed that "pipes dug up from the garden of Shakespeare's home in Stratford-uponAvon contain traces of cannabis."[99] The chemical analysis was carried out after researchers hypothesized that the "noted weed" mentioned in Sonnet 76 and the "journey in my head" from Sonnet 27 could be references to cannabis and the use thereof.[100]
Cannabis sativa from Vienna Dioscurides, 512 AD
John Gregory Bourke described use of "mariguan", which he identifies as Cannabis indica or Indian hemp, by Mexican residents of the Rio Grande region of Texas in 1894. He described its uses for treatment of asthma, to expedite delivery, to keep away witches, and as a love-philtre. He also wrote that many Mexicans added the herb to their cigarritos or mescal, often taking a bite of sugar afterward to intensify the effect. Bourke wrote that because it was often used in a mixture with toloachi (which he inaccurately describes as Datura stramonium), mariguan was one of several plants known as "loco weed". Bourke compared mariguan to hasheesh, which he called "one of the greatest curses of the East", citing reports that users "become maniacs and are apt to commit all sorts of acts of violence and murder", causing degeneration of the body and an idiotic appearance, and mentioned laws against sale of hasheesh "in most Eastern countries".[101][102][103] Cannabis was criminalized in various countries beginning in the early 20th century. In the United States, the first restrictions for sale of cannabis came in 1906 (in District of Columbia).[104] It was outlawed in South Africa in 1911, in Jamaica (then a British colony) in 1913, and in the United Kingdom and New Zealand in the 1920s.[105] Canada criminalized cannabis in the Opium and Drug Act of 1923, before any reports of use of the drug in Canada. In 1925 a compromise was made at an international conference in The Hague about the International Opium Convention that banned exportation of "Indian hemp" to countries that had prohibited its use, and requiring importing countries to issue certificates approving the importation and stating that the shipment was required "exclusively for medical or scientific purposes". It also required parties to "exercise an effective control of such a nature as to prevent the illicit international traffic in Indian hemp and especially in the resin".[106][107] In 1937 in the United States, the Marihuana Tax Act was passed, and prohibited the production of hemp in addition to cannabis. The reasons that hemp was also included in this law are disputed. Several scholars have claimed that the Act was passed in order to destroy the hemp industry,[108][109][110] largely as an effort of businessmen Andrew Mellon, Randolph Hearst, and the Du Pont family.[108][110] With the
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invention of the decorticator, hemp became a very cheap substitute for the paper pulp that was used in the newspaper industry.[108][111] Hearst felt that this was a threat to his extensive timber holdings. Mellon, Secretary of the Treasury and the wealthiest man in America, had invested heavily in the DuPont's new synthetic fiber, nylon, and considered its success to depend on its replacement of the traditional resource, hemp.[108][112][113][114][115][116][117][118] The claims that hemp could have been a successful substitute for wood pulp have been based on an incorrect government report of 1916 which concluded that hemp hurds, broken parts of the inner core of the hemp stem, were a suitable source for paper production. This has not been confirmed by later research, as hemp hurds are not reported to be a good enough substitute. Many advocates for hemp have greatly overestimated the proportion of useful cellulose in hemp hurds. In 2003, 95% of the hemp hurds in EU were used for animal bedding, almost 5% were used as building material.[119][120][121][122]
Legal status
Main article: Legality of cannabis See also: Prohibition of drugs and Drug liberalization Since the beginning of the 20th century, most countries have enacted laws against the cultivation, possession or transfer of cannabis. These laws have impacted adversely on the cannabis plant's cultivation for non-recreational purposes, but there are many regions where, under certain circumstances, handling of cannabis is legal or licensed. Many jurisdictions have lessened the penalties for possession of small quantities of cannabis, so that it is punished by confiscation and sometimes a fine, rather than imprisonment, focusing more on those who traffic the drug on the black market.
Cannabis propaganda sheet from 1935
In some areas where cannabis use has been historically tolerated, some new restrictions have been put in place, such as the closing of cannabis coffee shops near the borders of the Netherlands,[123] closing of coffee shops near secondary schools in the Netherlands and crackdowns on "Pusher Street" in Christiania, Copenhagen in 2004.[124][125] Some jurisdictions use free voluntary treatment programs and/or mandatory treatment programs for frequent known users. Simple possession can carry long prison terms in some countries, particularly in East Asia, where the sale of cannabis may lead to a sentence of life in prison or even execution. More recently however, many political parties, non-profit organizations and causes based on the legalization of medical cannabis and/or legalizing the plant entirely (with some restrictions) have emerged.
Price
The price or street value of cannabis varies widely depending on geographic area and potency.[126]
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In the United States, cannabis is overall the #4 value crop, and is #1 or #2 in many states including California, New York and Florida, averaging $3,000/lb.[127][128] It is believed to generate an estimated $36 billion market.[129] Most of the money is spent not on growing and producing but on smuggling the supply to buyers. The United Nations Office on Drugs and Crime claims in its 2008 World Drug Report that typical U.S. retail prices are $1015 per gram (approximately $280420 per ounce). Street prices in North America are known to range from about $150 to $400 per ounce, depending on quality.[130] The European Monitoring Centre for Drugs and Drug Addiction reports that typical retail prices in Europe for cannabis varies from 2 to 14 per gram, with a majority of European countries reporting prices in the range 410.[131] In the United Kingdom, a cannabis plant has an approximate street value of 300,[132] but retails to the end-user at about 160/oz.
Truth serum
Cannabis was used as a truth serum by the Office of Strategic Services (OSS), a US government intelligence agency formed during World War II. In the early 1940s, it was the most effective truth drug developed at the OSS labs at St. Elizabeths Hospital; it caused a subject "to be loquacious and free in his impartation of information."[133] In May 1943, Major George Hunter White, head of OSS counterintelligence operations in the US, arranged a meeting with Augusto Del Gracio, an enforcer for gangster Lucky Luciano. Del Gracio was given cigarettes spiked with THC concentrate from cannabis, and subsequently talked openly about Luciano's heroin operation. On a second occasion the dosage was increased such that Del Gracio passed out for two hours.
[133]
Breeding and cultivation

Main article: Cannabis cultivation It is often claimed by growers and breeders of herbal cannabis that Maturing female Cannabis advances in breeding and cultivation techniques have increased the plant potency of cannabis since the late 1960s and early '70s, when THC was first discovered and understood. However, potent seedless cannabis such as "Thai sticks" were already available at that time. Sinsemilla (Spanish for "without seed") is the dried, seedless inflorescences of female cannabis plants. Because THC production drops off once pollination occurs, the male plants (which produce little THC themselves) are eliminated before they shed pollen to prevent pollination. Advanced cultivation techniques such as hydroponics, cloning, high-intensity artificial lighting, and the sea of green method are frequently employed as a response (in part) to prohibition enforcement efforts that make outdoor cultivation more risky. It is often cited that the average levels of THC in cannabis sold in United States rose dramatically between the 1970s and 2000, but such statements are likely skewed because of undue weight given to much more expensive and potent, but less prevalent samples.[134] The average THC level in coffee shops in the Netherlands is
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currently about 1819%, but new regulations adopted by the Dutch government in 2011 will force the THC content of cannabis sold in coffee shops to be limited to 15%, stating that cannabis in excess of 15% THC will be reclassified as a hard drug. These new regulations take effect in 2012.[135][136]
In arts and literature

Les paradis artificiels by Charles Baudelaire The Hasheesh Eater by Fitz Hugh Ludlow
See also
Addiction Recovery Marijuana Anonymous Cannabis plant Bhang Hemp oil Marijuana strains Autoflowering cannabis Thai stick
Cannabis legality Cannabis political parties Global Marijuana March Legal and medical status of cannabis Legal history of cannabis in the United States Legality of cannabis by country Marijuana Control, Regulation, and Education Act Marijuana Policy Project Marihuana Tax Act of 1937 National Organization for the Reform of Marijuana Laws
Cannabis use demographics Adult lifetime cannabis use by country Annual cannabis use by country
Footnotes
^ a: Weed,[137] pot,[138] and herb[139] are among the many other nicknames for marijuana or cannabis as a drug.[140] ^ b: Sources for this section and more information can be found in the Medical cannabis article
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Citations
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72. ^ AlterNet, 28 July 2010, Has the Most Common Marijuana Test Resulted in Tens of Thousands of Wrongful Convictions? (http://www.alternet.org/investigations/147613/has_the_most_common_marijuana_test_resulted_in_tens_of_thousan 73. ^ Venkatratnam, Abhishek; Nathan H. Lents (July 2011). "Zinc Reduces the Detection of Cocaine, Methamphetamine, and THC by ELISA Urine Testing" (http://jat.oxfordjournals.org/content/35/6/333.short) . Journal of Analytical Toxicology 35 (6): 333 340. doi:10.1093/anatox/35.6.333 (http://dx.doi.org/10.1093%2Fanatox%2F35.6.333) . PMID 21740689 (//www.ncbi.nlm.nih.gov/pubmed/21740689) . http://jat.oxfordjournals.org/content/35/6/333.short. 74. ^ a b c "RAND study casts doubt on claims that marijuana acts as "gateway" to the use of cocaine and heroin" (http://web.archive.org/web/20061104124529/http://www.rand.org/news/press.02/gateway.html) . RAND Corporation. 2002-12-02. Archived from the original (http://www.rand.org/news/press.02/gateway.html) on 2006-11-04. http://web.archive.org/web/20061104124529/http://www.rand.org/news/press.02/gateway.html. 75. ^ Lundin, Leigh (2009-03-01). "The Great Smoke-Out" (http://www.criminalbrief.com/?p=5445) . Criminal Brief. http://www.criminalbrief.com/?p=5445. 76. ^ a b Torabi MR, Bailey WJ, Majd-Jabbari M (1993). "Cigarette Smoking as a Predictor of Alcohol and Other Drug Use by Children and Adolescents: Evidence of the "Gateway Drug Effect"". The Journal of School Health 63 (7): 302306. doi:10.1111/j.1746-1561.1993.tb06150.x (http://dx.doi.org/10.1111%2Fj.17461561.1993.tb06150.x) . PMID 8246462 (//www.ncbi.nlm.nih.gov/pubmed/8246462) . 77. ^ Australian Government Department of Health: National Cannabis Strategy Consultation Paper (http://www.groups.psychology.org.au/Assets/Files/National_Cannabis_Strategy_Consultation_Paper.pdf) , p. 4. "Cannabis has been described as a 'Trojan Horse' for nicotine addiction, given the usual method of mixing Cannabis with tobacco when preparing marijuana for administration." 78. ^ Hall WD, Lynskey M (January 2005). "Is Cannabis A Gateway Drug? Testing Hypotheses About the Relationship Between Cannabis Use and the Use of Other Illicit Drugs" (http://www.informaworld.com/openurl? genre=article&doi=10.1080/09595230500126698&magic=pubmed%7C% 7C1B69BA326FFE69C3F0A8F227DF8201D0) . Drug and Alcohol Review 24 (1): 3948. doi:10.1080/09595230500126698 (http://dx.doi.org/10.1080%2F09595230500126698) . PMID 16191720 (//www.ncbi.nlm.nih.gov/pubmed/16191720) . http://www.informaworld.com/openurl? genre=article&doi=10.1080/09595230500126698&magic=pubmed%7C% 7C1B69BA326FFE69C3F0A8F227DF8201D0. 79. ^ Saitz, Richard (2003-02-18). "Is marijuana a gateway drug?" (http://generalmedicine.jwatch.org/cgi/content/full/2003/218/1) . Journal Watch 2003 (218): 1. http://generalmedicine.jwatch.org/cgi/content/full/2003/218/1. 80. ^ Degenhardt, Louisa et al. (2007). "Who are the new amphetamine users? A 10-year prospective study of young Australians" (http://www.blackwell-synergy.com/doi/abs/10.1111/j.1360-0443.2007.01906.x) . http://www.blackwell-synergy.com/doi/abs/10.1111/j.1360-0443.2007.01906.x. 81. ^ Morral AR, McCaffrey DF, Paddock SM (2002). "Reassessing the marijuana gateway effect" (http://www3.interscience.wiley.com/journal/118957921/abstract) . Addiction 97 (12): 1493504. doi:10.1046/j.1360-0443.2002.00280.x (http://dx.doi.org/10.1046%2Fj.1360-0443.2002.00280.x) . PMID 12472629 (//www.ncbi.nlm.nih.gov/pubmed/12472629) . http://www3.interscience.wiley.com/journal/118957921/abstract. 82. ^ "Marijuana Policy ProjectFAQ" (http://web.archive.org/web/20080622204803/http://www.mpp.org/about/faq.html) . Archived from the original (http://www.mpp.org/about/faq.html) on 2008-06-22. http://web.archive.org/web/20080622204803/http://www.mpp.org/about/faq.html. 83. ^ "Risk of marijuana's 'gateway effect' overblown, new research shows" (http://www.sciencedaily.com/releases/2010/09/100902073507.htm) . Sciencedaily.com. 2010-09-02. http://www.sciencedaily.com/releases/2010/09/100902073507.htm. Retrieved 2010-09-20. 84. ^ Stafford, Peter (1992). Psychedelics Encyclopedia (http://books.google.com/? id=Ec5hNgYWHtkC&printsec=frontcover) . Berkeley, CA, USA: Ronin Publishing. ISBN 0-914171-51-8. http://books.google.com/?id=Ec5hNgYWHtkC&printsec=frontcover. 85. ^ Matthews, A; Matthews, L (2007). Learning Chinese Characters (http://books.google.com/? id=YweFHwPd05EC&pg=PA336&lpg=PA336&dq=hemp+wood+shelter) . p. 336. ISBN 978-0-8048-38160. http://books.google.com/?id=YweFHwPd05EC&pg=PA336&lpg=PA336&dq=hemp+wood+shelter.
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107. ^ Opium as an international problem: the Geneva conferences Westel Woodbury Willoughby (http://books.google.com/books?id=GJm-XDLJe1QC) at Google Books 108. ^ a b c d French, Laurence; Manzanrez, Magdaleno (2004). NAFTA & neocolonialism: comparative criminal, human & social justice (http://books.google.com/?id=4ozF1Yg-c4MC&pg=PA129) . University Press of America. p. 129. ISBN 978-0-7618-2890-7. http://books.google.com/?id=4ozF1Yg-c4MC&pg=PA129. 109. ^ Earlywine, 2005: p. 24 (http://books.google.com/books?id=r9wPbxMAG8cC&pg=PA24) 110. ^ a b Peet, 2004: p. 55 (http://books.google.com/?id=uC0_YznYjScC&pg=PA55) 111. ^ Sterling Evans (2007). Bound in twine: the history and ecology of the henequen-wheat complex for Mexico and the American and Canadian Plains, 18801950 (http://books.google.com/books? id=_wFkZgyuGFAC&pg=PA27) . Texas A&M University Press. p. 27. ISBN 978-1-58544-596-7. http://books.google.com/books?id=_wFkZgyuGFAC&pg=PA27. 112. ^ Evans, Sterling, ed. (2006). The borderlands of the American and Canadian Wests: essays on regional history of the forty-ninth parallel (http://books.google.com/books?id=xBELvIaDXxAC&pg=PA199) . University of Nebraska Press. p. 199. ISBN 978-0-8032-1826-0. http://books.google.com/books? id=xBELvIaDXxAC&pg=PA199. 113. ^ Gerber, Rudolph Joseph (2004). Legalizing marijuana: drug policy reform and prohibition politics (http://books.google.com/books?id=WMOdI9pC-gEC&pg=PA7) . Greenwood Publishing Group. p. 7. ISBN 978-0-275-97448-0. http://books.google.com/books?id=WMOdI9pC-gEC&pg=PA7. 114. ^ Earleywine, Mitchell (2005). Understanding marijuana: a new look at the scientific evidence (http://books.google.com/books?id=r9wPbxMAG8cC&pg=PA231) . Oxford University Press. p. 231. ISBN 978-0-19-518295-8. http://books.google.com/books?id=r9wPbxMAG8cC&pg=PA231. 115. ^ Robinson, Matthew B & Scherlen, Renee G (2007). Lies, damned lies, and drug war statistics: a critical analysis of claims made by the office of National Drug Control Policy (http://books.google.com/books? id=dwGpsNjv_1kC&pg=PA12) . SUNY Press. p. 12. ISBN 978-0-7914-6975-0. http://books.google.com/books?id=dwGpsNjv_1kC&pg=PA12. 116. ^ Rowe, Thomas C (2006). Federal narcotics laws and the war on drugs: money down a rat hole (http://books.google.com/books?id=v1tz6nP6fdwC&pg=PA26) . Psychology Press. p. 26. ISBN 978-0-78902808-2. http://books.google.com/books?id=v1tz6nP6fdwC&pg=PA26. 117. ^ Sullivan, Larry E et al, ed. (2005). Encyclopedia of Law Enforcement: Federal (http://books.google.com/books?id=FtgYAAAAIAAJ&q=hearst+hemp&dq=hearst+hemp) . SAGE. p. 747. ISBN 978-0-7619-2649-8. http://books.google.com/books? id=FtgYAAAAIAAJ&q=hearst+hemp&dq=hearst+hemp. 118. ^ Lusane, Clarence (1991). Pipe dream blues: racism and the war on drugs (http://books.google.com/books? id=flIjcQBwu68C&pg=PA37) . South End Press. pp. 378. ISBN 978-0-89608-410-0. http://books.google.com/books?id=flIjcQBwu68C&pg=PA37. 119. ^ Lyster H. Dewey and Jason L. Merrill Hemp Hurds as Paper-Making Material (http://www.gutenberg.org/etext/17855) USDA Bulletin No. 404, Washington, DC, October 14, 1916, p. 25. 120. ^ "Hayo MG van der Werf: Hemp facts and hemp fiction" (http://www.hempfood.com/iha/iha01213.html) . Hempfood.com. http://www.hempfood.com/iha/iha01213.html. Retrieved 2011-10-30. 121. ^ "Dr. Ivan Bcsa, GATE Agricultural Research Institute, Kompolt Hungary, Book Review Re-discovery of the Crop Plant Cannabis Marihuana Hemp (Die Wiederentdeckung der Nutzplanze Cannabis Marihuana Hanf)" (http://www.hempfood.com/iha/iha01214.html) . Hempfood.com. http://www.hempfood.com/iha/iha01214.html. Retrieved 2011-10-30. 122. ^ Michael Karus: European Hemp Industry 2002 Cultivation, Processing and Product Lines. Journal of Industrial Hemp Volume 9 Issue 2 2004, Taylor & Francis, London (http://www.informaworld.com/smpp/content~db=all~content=a902981619~frm=titlelink) . 123. ^ "Many Dutch coffee shops close as liberal policies change, Exaptica" (http://www.expatica.com/nl/leisure/arts_culture/many-dutch-coffee-shops-close-as-liberalpolicies-change-46376.html) . Expatica.com. 2007-11-27. http://www.expatica.com/nl/leisure/arts_culture/many-dutch-coffee-shops-close-as-liberal-policies-change46376.html. Retrieved 2010-09-20. 124. ^ EMCDDA Cannabis reader (http://www.emcdda.europa.eu/attachements.cfm/att_53355_EN_emcddacannabis-mon-full-2vols-web.pdf) : Global issues and local experiences, Perspectives on Cannabis controversies, treatment and regulation in Europe, 2008, p. 157.
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125. ^ "43 Amsterdam coffee shops to close door" (http://www.rnw.nl/internationaljustice/news/international/6061587/43-Amsterdam-coffee-shops-toclose-doors) , Radio Netherlands, Friday 21 November 2008 126. ^ "UNODC.org" (http://www.unodc.org/pdf/WDR_2005/volume_2_chap7_cannabis.pdf) (PDF). http://www.unodc.org/pdf/WDR_2005/volume_2_chap7_cannabis.pdf. Retrieved 2010-09-20. 127. ^ "Report on U.S. Domestic Marijuana Production" (http://norml.org/index.cfm?Group_ID=4444) . NORML. http://norml.org/index.cfm?Group_ID=4444. Retrieved 2010-01-02. 128. ^ "Marijuana Crop Reports" (http://norml.org/index.cfm?Group_ID=4414) . NORML. http://norml.org/index.cfm?Group_ID=4414. Retrieved 2010-01-02. 129. ^ "Marijuana Called Top U.S. Cash Crop" (http://abcnews.go.com/business/story?id=2735017&page=1) . 2008 ABCNews Internet Ventures. http://abcnews.go.com/business/story?id=2735017&page=1. 130. ^ United Nations Office on Drugs and Crime (2008) (PDF). World drug report (http://www.unodc.org/documents/wdr/WDR_2008/WDR_2008_eng_web.pdf) . United Nations Publications. p. 264. ISBN 978-92-1-148229-4. http://www.unodc.org/documents/wdr/WDR_2008/WDR_2008_eng_web.pdf. 131. ^ European Monitoring Centre for Drugs and Drug Addiction (2008) (PDF). Annual report: the state of the drugs problem in Europe (http://www.emcdda.europa.eu/attachements.cfm/att_64227_EN_EMCDDA_AR08_en.pdf) . Luxembourg: Office for Official Publications of the European Communities. p. 38. ISBN 978-92-9168-324-6. http://www.emcdda.europa.eu/attachements.cfm/att_64227_EN_EMCDDA_AR08_en.pdf. 132. ^ Dearne Safer Neighbourhood Team (SNT) recovers cannabis with a street value of approximately 9,000 (http://www.southyorks.police.uk/news/newssyp/dearnesaferneighbourhoodteamsntrecoverscannabisstreetvalueappro 133. ^ a b Cockburn, Alexander; Jeffrey St. Clair (1998). Whiteout: The CIA, Drugs and the Press (http://books.google.com/?id=s5qIj_h_PtkC&printsec=frontcover#PPA118,M1) . Verso. pp. 117118. ISBN 1-85984-139-2. http://books.google.com/?id=s5qIj_h_PtkC&printsec=frontcover#PPA118,M1. 134. ^ Daniel Forbes (November 19, 2002). "The Myth of Potent Pot" (http://www.slate.com/id/2074151) . Slate.com. http://www.slate.com/id/2074151. 135. ^ "World Drug Report 2006" (http://www.unodc.org/unodc/en/data-and-analysis/WDR-2006.html) . United Nations Office on Drugs and Crime. http://www.unodc.org/unodc/en/data-and-analysis/WDR-2006.html. Ch. 2.3. 136. ^ "Dutch to reclassify high-strength cannabis" (http://www.bbc.co.uk/news/world-europe-15225270) . BBC News. 2011-10-07. http://www.bbc.co.uk/news/world-europe-15225270. 137. ^ Weed - Definition (http://www.merriam-webster.com/dictionary/weed) , Merriam-Webster Dictionary, http://www.merriam-webster.com/dictionary/weed, retrieved 2012-10-09 138. ^ Pot - Definition (http://www.merriam-webster.com/dictionary/pot) , Merriam-Webster Dictionary, http://www.merriam-webster.com/dictionary/pot, retrieved 2012-10-09 139. ^ Herb - Definition (http://www.merriam-webster.com/dictionary/herb) , Merriam-Webster Dictionary, http://www.merriam-webster.com/dictionary/herb, retrieved 2012-10-09 140. ^ "Marijuana Dictionary" (http://www.marijuanadictionary.com/) . http://www.marijuanadictionary.com/.
Further reading
Booth, Martin (2005). Cannabis: A History. Macmillan Publishers & Random House, Inc. ISBN 978-0-31242494-7. Deitch, Robert (2003). Hemp: American history revisited: the plant with a divided history (http://books.google.ca/books?id=PKDrpeRRY94C&lpg=PA9&dq=History%20of% 20Cannabis&pg=PP1#v=onepage&q&f=true) . Algora Pub. ISBN 0-87586-206-3. http://books.google.ca/books?id=PKDrpeRRY94C&lpg=PA9&dq=History%20of% 20Cannabis&pg=PP1#v=onepage&q&f=true Earleywine, Mitchell (2005). Understanding marijuana: a new look at the scientific evidence (http://books.google.ca/books?id=r9wPbxMAG8cC&lpg=PA3&dq=History%20of% 20Cannabis&pg=PP1#v=onepage&q&f=true) . Oxford University Press. ISBN 0-19-513893-7. http://books.google.ca/books?id=r9wPbxMAG8cC&lpg=PA3&dq=History%20of% 20Cannabis&pg=PP1#v=onepage&q&f=true
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Emmett, David; Graeme Nice (2009). What you need to know about cannabis: understanding the facts (http://books.google.ca/books?id=dHAy6T_LSV4C&lpg=PA55&dq=History%20of% 20Cannabis&pg=PP1#v=onepage&q&f=true) . Jessica Kingsley Publishers. ISBN 1-84310-697-3. http://books.google.ca/books?id=dHAy6T_LSV4C&lpg=PA55&dq=History%20of% 20Cannabis&pg=PP1#v=onepage&q&f=true Geoffrey William, Guy; Brian Anthony Whittle, Philip Robson (2004). The medicinal uses of cannabis and cannabinoids (http://books.google.ca/books?id=AznCzOxvrtwC&lpg=PA1&dq=History%20of% 20Cannabis&pg=PP1#v=onepage&q&f=true) . Pharmaceutical Press. ISBN 0-85369-517-2. http://books.google.ca/books?id=AznCzOxvrtwC&lpg=PA1&dq=History%20of% 20Cannabis&pg=PP1#v=onepage&q&f=true Holland, Julie M.D. (2010). The pot book : a complete guide to cannabis : its role in medicine, politics, science, and culture (http://books.google.ca/books? id=MQql_gt2QEgC&lpg=PA316&dq=Cannabis&pg=PP1#v=onepage&q&f=true) . Park Street Press. ISBN 978-1-59477-368-6. http://books.google.ca/books? id=MQql_gt2QEgC&lpg=PA316&dq=Cannabis&pg=PP1#v=onepage&q&f=true Iversen, Leslie L (2008). The science of marijuana (http://books.google.ca/books? id=l8O2OMNLNtcC&lpg=PA17&dq=History%20of%20Cannabis&pg=PP1#v=onepage&q&f=true) (2nd ed.). Oxford University Press. ISBN 978-0-19-532824-0. http://books.google.ca/books? id=l8O2OMNLNtcC&lpg=PA17&dq=History%20of%20Cannabis&pg=PP1#v=onepage&q&f=true Jenkins, Richard (2006). Cannabis and young people: reviewing the evidence (http://books.google.ca/books? id=bFDznfmJLnAC&lpg=PP1&dq=Cannabis&pg=PP1#v=onepage&q&f=true) . Jessica Kingsley. ISBN 184310-398-2. http://books.google.ca/books? id=bFDznfmJLnAC&lpg=PP1&dq=Cannabis&pg=PP1#v=onepage&q&f=true Lambert, Didier M (2008). Cannabinoids in Nature and Medicine (http://books.google.ca/books? id=ATDRt1HM9MwC&lpg=PA15&dq=History%20of%20Cannabis&pg=PR11#v=onepage&q&f=true) . Wiley-VCH. ISBN 3-906390-56-X. http://books.google.ca/books? id=ATDRt1HM9MwC&lpg=PA15&dq=History%20of%20Cannabis&pg=PR11#v=onepage&q&f=true Roffman, Roger A; Robert S. Stephens (2006). Cannabis dependence: its nature, consequences, and treatment (http://books.google.ca/books?id=DEWRoPweosEC&lpg=PA89&dq=History%20of% 20Cannabis&pg=PP1#v=onepage&q&f=true) . Cambridge University Press. ISBN 0-521-81447-2. http://books.google.ca/books?id=DEWRoPweosEC&lpg=PA89&dq=History%20of% 20Cannabis&pg=PP1#v=onepage&q&f=true Russo, Ethan; Melanie Creagan Dreher, Mary Lynn Mathre (2004). Women and cannabis: medicine, science, and sociology (http://books.google.ca/books?id=gZJ7m3Uf6FQC&lpg=PA29&dq=History%20of% 20Cannabis&pg=PP1#v=onepage&q&f=true) . Haworth Press. ISBN 0-7890-2101-3. http://books.google.ca/books?id=gZJ7m3Uf6FQC&lpg=PA29&dq=History%20of% 20Cannabis&pg=PP1#v=onepage&q&f=true Solowij, Nadia (1998). Cannabis and cognitive functioning (http://books.google.ca/books? id=bL2u5RRYIpcC&lpg=PA84&dq=History%20of%20Cannabis&pg=PP1#v=onepage&q&f=true) . Cambridge University Press. ISBN 0-521-59114-7. http://books.google.ca/books? id=bL2u5RRYIpcC&lpg=PA84&dq=History%20of%20Cannabis&pg=PP1#v=onepage&q&f=true
External links
Wiktionary Appendix of Cannabis Slang Montana PBS documentary,Clearing the Smoke (http://topdocumentaryfilms.com/clearing-thesmoke-the-science-of-cannabis/? utm_source=feedburner&utm_medium=email&utm_campaign=Feed% 3A+TopDocumentaryFilms+%28Top+Documentary+Films++Watch+Free+Documentaries+Online%29) Cannabis (Marijuana) (http://www.erowid.org/plants/cannabis/) Erowid Reefer Madness! (http://www.life.com/gallery/51331/reefer-madness#index/0) slideshow by Life magazine
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"Cannabis: a health perspective and research agenda" (http://whqlibdoc.who.int/hq/1997/WHO_MSA_PSA_97.4.pdf) , Programme on Substance Abuse, World Health Organization, 1997 Retrieved from "http://en.wikipedia.org/w/index.php?title=Cannabis_(drug)&oldid=520874688" Categories: Cannabis Cannabis smoking Entheogens Euphoriants Psychedelics, dissociatives and deliriants This page was last modified on 1 November 2012 at 10:01. Text is available under the Creative Commons Attribution-ShareAlike License; additional terms may apply. See Terms of Use for details. Wikipedia is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization.
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People of the Hadza ethnic group in north-central Tanzania smoking cannabis