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  • Cytokine Role Source IL-3 IL-5 IL-7 C-Kit Ligand G-CSF M-CSF GM-CSF IFN-Gamma

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    mliou0417
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    The document lists various cytokines, their sources, roles in hematopoiesis and immune functions, and cells they activate. It describes how cytokines such as IL-3, IL-5, IL-7, and others influence the differentiation and functions of immune cells like T cells, macrophages, and dendritic cells in hematopoiesis and immune responses.

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    Cytokine List

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    The document lists various cytokines, their sources, roles in hematopoiesis and immune functions, and cells they activate. It describes how cytokines such as IL-3, IL-5, IL-7, and others influence the differentiation and functions of immune cells like T cells, macrophages, and dendritic cells in hematopoiesis and immune responses.

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    10 views2 pages

    Cytokine Role Source IL-3 IL-5 IL-7 C-Kit Ligand G-CSF M-CSF GM-CSF IFN-Gamma

    Uploaded by

    mliou0417
    The document lists various cytokines, their sources, roles in hematopoiesis and immune functions, and cells they activate. It describes how cytokines such as IL-3, IL-5, IL-7, and others influence the differentiation and functions of immune cells like T cells, macrophages, and dendritic cells in hematopoiesis and immune responses.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as XLS, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as xls, pdf, or txt
    of 2

    Cytokine IL-3 IL-5 IL-7 C-Kit Ligand G-CSF M-CSF GM-CSF IFN-Gamma

    Role Full Hematopoiesis (Both Myleoid and Lymphoid Progenitors) Hematopoiesis Differentiation, Activation & Chemotasis of Eosinophils T Cell Production from Lymphoid Progenitor Hematopoiesis Hematopoiesis Hematopoiesis Hematopoiesis

    Source T Cells Th2 Mast Cells Bone Marrow Stromal Cells Monocytes/ Macrophages Monocytes/ Macrophages Monocytes/ Macrophages T Cells Th1 Tho NK Cells Th2 Mast Cells Th2

    Activates iNOS Enhances Activity of NADPH oxidase in phagosomes Down-regulates Type2 CKs Tho > Th1 PreCTL > CTL TFG-Beta Down-regulates iNOS IL-4 Isotype Switching to IgE Tho > Th2 Down-regulates Type1 CKs Inhibits iNOS (minor) IL-10 Down-regulates Type1 CKs Inhibits IL-12 Down-regulates iNOS IL-12 Tho > Th1 Stimulates NK Cell Secretion of IFN-Gamma IL-2 T Cell Growth Factor (especially of Cytoxic T Cells) Activates NK Cells Tho > Clonal expansion IL-1 & TNF (synergy) De novo expression VCAM-1 & ICAM-1 MCP-1 & IL-8 Lowers Blood Pressure & Shock TNF (Alpha & Beta) Activates Macrophages IL-6 Stimulates Liver secretion of CR Protein (inflammation)

    Th2

    Macrophages Dendritic Cells Th1 Thp Tho Macrophages Macrophages (Th1 > TNF) Activated Macrophages Th1 Activated Macrophages

    IFN Alpha/Beta (Type 1) Protects neighboring cells from Viral infection (Hep-C treatment)

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