Chemical Engineering Department

EXPERIMENT No: 08 DETERMINATION OF ASPIRIN CONTENT

AIM: to determine the aspirin content of the given sample. APPARATUSE: burette, pipette, conical flask, beaker, watch glass, weight box. REQUIREMENT: 0.5 N NaOH solution 0.5 N HCL, phenolphthalein indicator. PROCESS: 1. Accurately weight 0.5 gm of sample and dissolve it in 10 ml of methanol. 2. Add 50 ml of 0.5 N NaOH. 3. Immerse the flask in boiling water bath for 20 min and cool it. 4. Back titrate the excess alkali with 0.5 N HCL using phenolphthalein indicators. 5. Carry out the blank titration (without the addition of aspirin sample) under the similar conditions. 6. Color changes from light pink to colorless. OBSERVATION: 1. Burette reading (sample) = X ml remained after reaction (excess) 2. Burette reading (blank) = Y ml - taken 3. Burette reading (difference) = Y-X = Z ml = taken remained = reacted CALCULATION: % of aspirin = 0.09008 * 0.5 N HCL * Z ml * 100 Weight of sample = _______ % RESULT: % of aspirin in the given sample is = ________ %

Aspirin content