DRUG ANALYSIS

Name of Drug metoprolol

Generic Name

Dosage 50 mg/tab BID

Indication Metoprolol selectively inhibits adrenergic receptors but has little or no effect on 2receptors except in high doses.

Drug Interaction Other medications can affect the removal of metoprolol from your body, which may affect how metoprolol works. Examples include lumefantrine, propafenone, quinidine, SSRI antidepress ants (such as fluoxetine, paroxetine), St. John's wort, among others. may further aggravate hypotension

Adverse Effect Bradycardia, hypotension, arterial insufficiency, chest pain, CHF, , palpitation, syncope, dizziness, fatigue, depression, confusion, headache, insomnia, shortterm memory loss, rash, sexual dysfunction/impote nce,; diarrhea, constipation, flatulence, GI pain, heartburn, nausea, Heart failure, heart block, bronchospasm.

Nursing Responsibility Take apical pulse and BP before administering drug. Report to physician significant changes in rate, rhythm, or quality of pulse or variations in BP prior to administration. Monitor BP, HR, and ECG carefully during administration Expect maximal effect on BP after 1 week of therapy Monitor I&O, daily weight, auscultate daily for pulmonary rales. Observe hypertensive patients with CHF closely for impending heart failure. Dyspnea on exertion, orthopnea, night cough, edema, distended neck veins.