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  • Reformatsky Reaction: Organic Reaction Condenses Aldehydes Ketones Esters Zinc Sergey Nikolaevich Reformatsky

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    Ronit Singh
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    The Reformatsky reaction is an organic reaction that condenses aldehydes or ketones with α-halo esters using metallic zinc to form β-hydroxy-esters. It was discovered by Sergey Nikolaevich Reformatsky. An organozinc reagent called a 'Reformatsky enolate' is prepared by treating an alpha-halo ester with zinc dust. Reformatsky enolates are less reactive than other enolates so they do not undergo nucleophilic addition to the ester group.

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    Reformatsky Reaction

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    The Reformatsky reaction is an organic reaction that condenses aldehydes or ketones with α-halo esters using metallic zinc to form β-hydroxy-esters. It was discovered by Sergey Nikolaevich Reformatsky. An organozinc reagent called a 'Reformatsky enolate' is prepared by treating an alpha-halo ester with zinc dust. Reformatsky enolates are less reactive than other enolates so they do not undergo nucleophilic addition to the ester group.

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    113 views1 page

    Reformatsky Reaction: Organic Reaction Condenses Aldehydes Ketones Esters Zinc Sergey Nikolaevich Reformatsky

    Uploaded by

    Ronit Singh
    The Reformatsky reaction is an organic reaction that condenses aldehydes or ketones with α-halo esters using metallic zinc to form β-hydroxy-esters. It was discovered by Sergey Nikolaevich Reformatsky. An organozinc reagent called a 'Reformatsky enolate' is prepared by treating an alpha-halo ester with zinc dust. Reformatsky enolates are less reactive than other enolates so they do not undergo nucleophilic addition to the ester group.

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    Reformatsky reaction

    From Wikipedia, the free encyclopedia

    The Reformatsky reaction (sometimes spelled Reformatskii reaction) is an organic reaction which condenses aldehydes (or ketones), 1, with -halo esters, 2, using a metallic zinc to form hydroxy-esters, 3.[1][2] It was discovered by Sergey Nikolaevich Reformatsky.

    The organozinc reagent, also called a 'Reformatsky enolate', is prepared by treating an alpha-halo ester with zinc dust. Reformatsky enolates are less reactive than lithium enolates or Grignard reagents and hence nucleophilic addition to the ester group does not occur.

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