Scribd Logo
Upload

Welcome to Scribd!

  • The Role of Antileukotriene Therapy in Seasonal Allergic Rhinitis: A Systematic Review of Randomized Trials

    Uploaded by

    Fernia Stevani
    25 views2 pages
    This systematic review analyzed 17 studies and over 6,000 adults with seasonal allergic rhinitis. It found that oral leukotriene receptor antagonists significantly reduced daytime and nighttime nasal symptoms as well as eye symptoms compared to placebo, and improved quality of life. There was no significant difference found between oral leukotriene receptor antagonists and oral antihistamines. However, intranasal corticosteroids were found to be more effective than leukotriene receptor antagonists at reducing nasal symptoms. A combination of leukotriene receptor antagonists and antihistamines provided better relief of eye symptoms than antihistamines alone, but was still inferior to intranasal corticosteroids for

    Original Description:

    LEUKOTRIENE ADALAH

    Original Title

    kegunaan leukotriene

    Copyright

    © Attribution Non-Commercial (BY-NC)

    Available Formats

    DOCX, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Report this Document
    This systematic review analyzed 17 studies and over 6,000 adults with seasonal allergic rhinitis. It found that oral leukotriene receptor antagonists significantly reduced daytime and nighttime nasal symptoms as well as eye symptoms compared to placebo, and improved quality of life. There was no significant difference found between oral leukotriene receptor antagonists and oral antihistamines. However, intranasal corticosteroids were found to be more effective than leukotriene receptor antagonists at reducing nasal symptoms. A combination of leukotriene receptor antagonists and antihistamines provided better relief of eye symptoms than antihistamines alone, but was still inferior to intranasal corticosteroids for

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOCX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as docx, pdf, or txt
    25 views2 pages

    The Role of Antileukotriene Therapy in Seasonal Allergic Rhinitis: A Systematic Review of Randomized Trials

    Uploaded by

    Fernia Stevani
    This systematic review analyzed 17 studies and over 6,000 adults with seasonal allergic rhinitis. It found that oral leukotriene receptor antagonists significantly reduced daytime and nighttime nasal symptoms as well as eye symptoms compared to placebo, and improved quality of life. There was no significant difference found between oral leukotriene receptor antagonists and oral antihistamines. However, intranasal corticosteroids were found to be more effective than leukotriene receptor antagonists at reducing nasal symptoms. A combination of leukotriene receptor antagonists and antihistamines provided better relief of eye symptoms than antihistamines alone, but was still inferior to intranasal corticosteroids for

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOCX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as docx, pdf, or txt
    of 2

    The role of antileukotriene therapy in seasonal allergic rhinitis: a systematic review of randomized trials.

    Rodrigo GJ, Yaez A.

    Source
    Departamento de Emergencia, Hospital Central de las Fuerzas Armadas, and Clinica Respirar, Benito Nardone, Montevideo, Uruguay. gurodrig@adinet.com.uy

    Abstract
    OBJECTIVE: To evaluate the effect of oral leukotriene receptor antagonists as monotherapy or combined with other drugs in the treatment of seasonal allergic rhinitis. DATA SOURCES: The MEDLINE, EMBASE, CINAHL (Cumulative Index to Nursing and Allied Health), and Cochrane databases; review articles; and references of included trials. STUDY SELECTION: Published (1966-2005) randomized controlled trials with nasal and eye symptoms and quality-of-life scores as primary outcomes. RESULTS: Seventeen studies including 6,231 adults with seasonal allergic rhinitis were selected. Oral leukotriene antagonists significantly reduced daytime nasal symptoms (standardized mean difference [SMD], -0.24; 95% confidence interval [CI], -0.33 to -0.16), nighttime nasal symptoms (SMD, -0.23; 95% CI, -0.30 to -0.16), and eye symptoms and significantly improved quality of life compared with placebo. There were no significant differences between oral leukotriene antagonists and oral histamine H1 antagonists on nasal and eye symptoms and quality-of-life overall score. We also found that leukotriene receptor antagonists were inferior to intranasal corticosteroids for decreasing daytime (SMD, 0.41; 95% CI, 0.27 to 0.56) and nighttime nasal symptoms. The combination of leukotriene receptor antagonists plus histamine H1 antagonists produced greater relief of eye symptoms compared with histamine H1 antagonists alone. Finally, intranasal corticosteroids significantly reduced nasal congestion compared with leukotriene receptor antagonists plus histamine H1 antagonists. CONCLUSIONS:

    Leukotriene receptor antagonists were better than placebo, equivalent to oral histamine H1 antagonists, and inferior to intranasal corticosteroids for treating seasonal allergic rhinitis. Alternatively, leukotriene receptor antagonists plus histamine H1 antagonists were more effective than histamine H1 antagonists alone but inferior to intranasal corticosteroids.
    Ann Allergy Asthma Immunol. 2006 Jun;96(6):779-86.

    You might also like