Hyperlipidemia

Type III

Noura AlNaqbi
Alia Alteneji
Huda Ibrahim
Hyperlipidemia
 Different types of hyperlipidemia appear at
different ages.
 When hyperlipidemia is defined in terms of
classes of elevated lipoproteins in the
blood, the term hyperlipoproteinemia is
used.
What is type III hyperlipidemia?

 Type III hyperlipidemia is a rare kind of

combined hyperlipidemia, in which both
cholesterol and triglyceride are increased in
the blood.
 This lead to accelerated atherosclerosis,
which causes heart attack, stroke, blockage
of leg arteries at a young age.
Key problem in Type III hyperlipidemia

 Is a failure of the liver to remove remnant

lipoproteins from the bloodstream.
Signe and symptoms
 Yellowish nodules in the skin beneath eyes,
elbows, knees and tendons.
 Enlarged liver and spleen.
 Discomfort or tenderness

in the upper abdomen.

Causes of Hyperlipidemia III
 Diet
 Hypothyroidism
 Nephrotic syndrome
 Anorexia nervosa
 Obstructive liver disease
 Obesity
 Diabetes mellitus
 Pregnancy
How is Hyperlipidemia Type III
inherited ?
 A bad gene for apoE attaches weakly to
surface .

 More common with

females than males.
Treatment
Treatment of Hyperlipidemia III
 Surgery to remove fat deposits in the skin
and tendons.

 Lifestyle modification:
 Low-cholesterol diet
 Exercise
Medications for Hyperlipidemia Type III

Agents Effects (% change) Side Effects

Lovastatin ↓LDL (18-55),↑ HDL (5-15) Myopathy, increased liver

Pravastatin ↓ Triglycerides (7-30) enzymes

Gemfibrozil ↓LDL (5-20), ↑HDL (10-20) Dyspepsia, gallstones,

Fenofibrate ↓Triglyceride (20-50) myopathy
 http://www.youtube.com/watch?v=7I_DD01THIU