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Pantothenic acid (Vitamin B5): MedlinePlus Supplements

Pantothenicacid(VitaminB5)
URLofthispage:http://www.nlm.nih.gov/medlineplus/druginfo/natural/853.html

Whatisit?
Pantothenicacidisavitamin,alsoknownasvitaminB5.Itiswidelyfoundinbothplantsandanimalsincludingmeat, vegetables,cerealgrains,legumes,eggs,andmilk. VitaminB5iscommerciallyavailableasDpantothenicacid,aswellasdexpanthenolandcalciumpantothenate,which arechemicalsmadeinthelabfromDpantothenicacid. PantothenicacidisfrequentlyusedincombinationwithotherBvitaminsinvitaminBcomplexformulations.VitaminB complexgenerallyincludesvitaminB1(thiamine),vitaminB2(riboflavin),vitaminB3(niacin/niacinamide),vitaminB5 (pantothenicacid),vitaminB6(pyridoxine),vitaminB12(cyanocobalamin),andfolicacid.However,someproductsdo notcontainalloftheseingredientsandsomemayincludeothers,suchasbiotin,paraaminobenzoicacid(PABA), cholinebitartrate,andinositol. Pantothenicacidhasalonglistofuses,althoughthereisntenoughscientificevidencetodeterminewhetheritis effectiveformostoftheseuses.Peopletakepantothenicacidfortreatingdietarydeficiencies,acne,alcoholism, allergies,baldness,asthma,attentiondeficithyperactivitydisorder(ADHD),autism,burningfeetsyndrome,yeast infections,heartfailure,carpaltunnelsyndrome,respiratorydisorders,celiacdisease,colitis,conjunctivitis, convulsions,andcystitis.Itisalsotakenbymouthfordandruff,depression,diabeticnervepain,enhancingimmune function,improvingathleticperformance,tongueinfections,grayhair,headache,hyperactivity,lowbloodsugar,trouble sleeping(insomnia),irritability,lowbloodpressure,multiplesclerosis,musculardystrophy,muscularcrampsinthelegs associatedwithpregnancyoralcoholism,neuralgia,andobesity. Pantothenicacidisalsousedorallyforosteoarthritis,rheumatoidarthritis,Parkinson'sdisease,nervepain, premenstrualsyndrome(PMS),enlargedprostate,protectionagainstmentalandphysicalstressandanxiety,reducing adverseeffectsofthyroidtherapyincongenitalhypothyroidism,reducingsignsofaging,reducingsusceptibilitytocolds andotherinfections,retardedgrowth,shingles,skindisorders,stimulatingadrenalglands,chronicfatiguesyndrome, salicylatetoxicity,streptomycinneurotoxicity,dizziness,andwoundhealing. Peopleapplydexpanthenol,whichismadefrompantothenicacid,totheskinforitching,promotinghealingofmild eczemasandotherskinconditions,insectstings,bites,poisonivy,diaperrash,andacne.Itisalsoappliedtopicallyfor preventingandtreatingskinreactionstoradiationtherapy.

Howeffectiveisit?
NaturalMedicinesComprehensiveDatabaserateseffectivenessbasedonscientificevidenceaccordingtothefollowing scale:Effective,LikelyEffective,PossiblyEffective,PossiblyIneffective,LikelyIneffective,Ineffective,and InsufficientEvidencetoRate.

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Pantothenic acid (Vitamin B5): MedlinePlus Supplements

TheeffectivenessratingsforPANTOTHENICACID(VITAMINB5)areasfollows: Effectivefor... Treatingorpreventingpantothenicaciddeficiency. Possiblyineffectivefor... Treatingorpreventingskinreactionsfromradiationtherapy. Insufficientevidencetorateeffectivenessfor... Attentiondeficithyperactivitydisorder(ADHD).Thereisconflictingevidenceregardingtheusefulnessof pantothenicacidincombinationwithlargedosesofothervitaminsforthetreatmentofADHD. Arthritis.Developingresearchsuggestspantothenicacid(givenascalciumpantothenate)doesnotsignificantly reducethesymptomsofarthritisinpeoplewithrheumatoidarthritis,osteoarthritis,orotherformsofarthritis. Improvingathleticperformance.Someresearchsuggeststhatpantothenicacidincombinationwithpantethine andthiaminedoesnotimprovemuscularstrengthorenduranceinwelltrainedathletes. Skinproblems. Alcoholism . Allergies. Hairloss. Asthma. Heartproblems. Carpaltunnelsyndrome. Lungdisorders. Colitis. Eyeinfections(conjunctivitis). Convulsions. Kidneydisorders. Dandruff. Depression. Diabeticproblems. Enhancingimmunefunction. Headache. Hyperactivity. Lowbloodpressure. Inabilitytosleep(insomnia). Irritability. Multiplesclerosis. Musculardystrophy. Musclecramps. Otherconditions. Moreevidenceisneededtoratetheeffectivenessofpantothenicacidfortheseuses.

Howdoesitwork?
Pantothenicacidisimportantforourbodiestoproperlyusecarbohydrates,proteins,andlipidsandforhealthyskin.

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Pantothenic acid (Vitamin B5): MedlinePlus Supplements

Aretheresafetyconcerns?
PantothenicacidisLIKELYSAFEformostpeoplewhenusedinappropriateamounts.Therecommendedamountfor adultsis5mgperday.Evenlargeramountsseemtobesafeforsomepeople,buttakinglargeramountsincreasesthe chanceofhavingsideeffectssuchasdiarrhea. Pantothenicacidseemstobesafeforchildrenwhenusedappropriately. Specialprecautions&warnings: Pregnancyandbreastfeeding:PantothenicacidisLIKELYSAFEwhentakeninrecommendedamountsof6mgper dayduringpregnancyand7mgperdayduringbreastfeeding.Butitisnotknowniftakingmorethanthisamountis safe. Hemophila:Donttakepantothenicacidifyouhavehemophila.Itmightextendthetimeittakesforbleedingtostop.

Arethereinteractionswithmedications?
Itisnotknownifthisproductinteractswithanymedicines. Beforetakingthisproduct,talkwithyourhealthprofessionalifyoutakeanymedications.

Arethereinteractionswithherbsandsupplements?
Royaljelly Royaljellycontainssignificantamountsofpantothenicacid.Theeffectsoftakingroyaljellyandpantothenicacid supplementstogetheraren'tknown.

Arethereinteractionswithfoods?
Therearenoknowninteractionswithfoods.

Whatdoseisused?
Thefollowingdoseshavebeenstudiedinscientificresearch: BYMOUTH: Asadietarysupplement:510mgofpantothenicacid(vitaminB5). Recommendeddailyintakesforpantothenicacid(vitaminB5)areasfollows:Infants06months,1.7mginfants712 months,1.8mgchildren13years,2mgchildren48years,3mgchildren913years,4mgmenandwomen14 yearsandolder,5mgpregnantwomen,6mgandbreastfeedingwomen,7mg.

Othernames
AcideDPantothnique,AcidePantothnique,cidoPantotnico,AlcoolPantothnylique,BComplexVitamin,Calcii Pantothenas,CalciumDPantothenate,CalciumPantothenate,ComplexedeVitaminesB,DCalciumPantothenate,D Panthenol,DPanthnol,DPantothnatedeCalcium,DPantothenicAcid,DPantothenylAlcohol,Dexpanthenol, Dexpanthnol,Dexpanthenolum,Pantthine,Panthenol,Panthnol,Pantothenate,Pantothnate,Pantothnatede
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Pantothenic acid (Vitamin B5): MedlinePlus Supplements

Calcium,Pantothenol,Pantothenylol,VitaminB5,VitaminB5,VitaminaB5,VitamineB5.

Methodology
Tolearnmoreabouthowthisarticlewaswritten,pleaseseetheNaturalMedicinesComprehensiveDatabase methodology(http://www.nlm.nih.gov/medlineplus/druginfo/natural/methodology.html).

References
ToseeallreferencesforthePantothenicacid(VitaminB5)page,pleasegoto http://www.nlm.nih.gov/medlineplus/druginfo/natural/853.html.
1. PlesofskyVigN.Pantothenicacid.In:ShilsME,OlsonJA,ShikeM,eds.ModernNutritioninHealthandDisease,8thed.Malvern,PA: Lea&Febiger,1994. 2. Anon.Calciumpantothenateinarthriticconditions.AreportfromtheGeneralPractitionerResearchGroup.Practitioner1980224:208 11. 3. WebsterMJ.Physiologicalandperformanceresponsestosupplementationwiththiaminandpantothenicacidderivatives.EurJAppl PhysiolOccupPhysiol199877:48691. 4. HaslamRH,DalbyJT,RademakerAW.Effectsofmegavitamintherapyonchildrenwithattentiondeficitdisorders.Pediatrics 198474:10311. 5. LokkevikE,SkovlundE,ReitanJB,etal.Skintreatmentwithbepanthencreamversusnocreamduringradiotherapyarandomized, controlledtrial.ActaOncol199635:10216. 6. FoodandNutritionBoard,InstituteofMedicine.DietaryReferenceIntakesforThiamin,Riboflavin,Niacin,VitaminB6,Folate,Vitamin B12,PantothenicAcid,Biotin,andCholine.Washington,DC:NationalAcademyPress,2000.Availableat: http://books.nap.edu/books/0309065542/html/. 7. DebourdeauPM,DjezzarS,EstivalJL,etal.LifethreateningeosinophilicpleuropericardialeffusionrelatedtovitaminsB5andH.Ann Pharmacother200135:4246. 8. BrennerA.TheeffectsofmegadosesofselectedBcomplexvitaminsonchildrenwithhyperkinesis:controlledstudieswithlongterm followup.JLearnDisabil198215:25864. 9. YatesAA,SchlickerSA,SuitorCW.Dietaryreferenceintakes:Thenewbasisforrecommendationsforcalciumandrelatednutrients,B vitamins,andcholine.JAmDietAssoc199898:699706. 10. KastrupEK.DrugFactsandComparisons.1998ed.St.Louis,MO:FactsandComparisons,1998.

Lastreviewed12/26/2012

Thiscopyrighted,evidencebasedmedicineresourceisprovidedbyNaturalMedicinesComprehensiveDatabaseConsumerVersion. NaturalMedicinesComprehensiveDatabasedisclaimsanyresponsibilityrelatedtoconsequencesofusinganyproduct.Thismonograph shouldnotreplaceadvicefromahealthcareprofessionalandshouldnotbeusedforthediagnosisortreatmentofanymedicalcondition. Copyright19952013TherapeuticResearchFaculty ,publishersofNaturalMedicines ComprehensiveDatabase,PrescribersLetter ,PharmacistsLetter .Allrightsreserved. Forscientificdataonnaturalmedicines,professionalsmayconsulttheProfessional VersionofNaturalMedicinesComprehensiveDatabase(http://www.naturaldatabase.com/).

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