M I TOCHONDRI AL STRUCTURE

FUNCTI ONAL ORGANI ZATI ON OF THE COM PARTM ENTS

ELECTRON CARRI ERS

1. Flavoproteins containing FM N or FAD accept and donate two (2) electrons and two (2) protons.

2. Cytochromes containing heme groups accept and donate only a single electron.
3. Copper center proteins accept and donate one electron at a time. 4. I ron-sulfur proteins accept and donate a single electron. 5. Ubiquinone (Coenzyme Q) is a lipid soluble molecule which can accept and donate two electrons and two protons.

THE FOUR COM PLEXES

THE Q-CYCLE

e Cyt c

CuA e Fe a
e

1 Fe3+ Cu2+

CYTOCHROM E OXI DASE

Matrix

Fe a CuB 3
1st e

II

2H 2O 2H + H+ OH 11 Fe3+ - OH Cu2+

O O OH

OH

10

Cu1+ Fe4+=O

Fe H

4th e 

Cu O

H
9

H H O Cu2+ Fe4+=O

OH H+

OH H

GROSS APPEARANCE FoF1-ATP SYNTHASE

STRUCTURE OF FoF1 ATP SYNTHASE

CONVERSI ON OF PROTON-M OTI VE FORCE TO ROTARY M OTI ON

BI NDI NG OF H + 727+(&68%81,7 NEUTRALI ZES THE NEGATI VE CHARGE OF Asp THEREBY PROM OTI NG M OVEM ENT OF THE NOW COM PLETELY HYDROPHOBI C C-UNI T WI THI N THE M EM BRANE LI PI D.

THE BI NDI NG CHANGE M ECHANI SM

ATP SYNTHASE ACTI VI TY

DEM ONSTRATI ON OF ROTARY M ECHANI SM

OVERALL ATP YI ELD

ATP/ADP EXCHANGE

REGULATI ON
CELLULAR ENERGY TRAPPI NG I S REGULATED BY NEGATI VE FEEDBACK TO AN ALLOSTERI C ENZYM E NEAR THE BEGI NNI NG OF GLYCOLYSI S