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Pathophysiology of Hypertensive Cardiovascular Disease
Pathophysiology of Hypertensive Cardiovascular Disease
ETIOLOGY Unknown
Increase intake of fats Fats clogs on arteries (arteriosclerosis) Narrowing of blood vessels (arteries) Increase vascular resistance Decrease blood flow to organs (kidneys) B A
Oxidative stress
Disregulation in interaction between MMP & inhibitors (TIMPS) Increase degredation of fibrilar collagen & extracellular matrix
OLIGURIA
A Augmentation of degradation of normal cell type collagen B A Activation of RAAS Myocyte stretch (other humeral stimuli such as angiotensin II, phenylephrine/ endothelin)
HYPERTENSION CARDIOMEGALY
Myocyte hypertrophy
Proliferation of fibroblast
Myofibroblast configuration
Atria beat very fast Blood pools in the atria Ventricles beat very fast Electrical signals originate from around the atria
Arrhythmia
ATRIAL FIBRILLATION