Clinical Medications Worksheets Generic Name

ISONIAZI D

Peak
1-2Hr

Trade Name INH, Isotamine, Nydrazid Onset

Classification
Antitubercular drug

Dose
300mg

Route
PO

Time/frequency
Daily 0830

Duration
2-5Hr

For IV meds, compatibility with IV drips and /or solutions Nursing Implications (what to focus on) Contraindications/warnings/interactions
Severe hypersensitivity to isoniazid or in clients with previous associated hepatic injury or side effects. Acute liver disease. Sometimes severe and fatal hepatitis can occur even after several months of therapy (daily alcohol users are at increased risk) Use caution for treatment of renal tuberculosis in clients with impaired renal function (EToH abuse) use lowest dose possible.

Mechanism of action and indications (Why med ordered)

Prophylaxis of Tuberculosis caused by human, Bovine and BCG Strains of Mycobacterium tuberculosis. Action: The most effective tuberculostatic agent. Interferes with lipid and nucleic acid metabolism of growing bacteria, resulting in the alteration of the bacterial wall.

Common side effects

Peripheral neuropathy, N&V, Heartburn, dizziness, optic neuritis, hepatitis.

Interactions with other patient drugs, OTC or herbal Lab value alterations caused by medicine medicines (ask patient specifically) Benzodiazepines Diazepam (PRN) Cause and increased effect of the diazepam. Rifampin Additive liver toxicity

Be sure to teach the patient the following about this medication

Take on empty stomach Consume 2-3L of fluids per day Avoid alcohol to prevent hepatic toxicity Pyridoxine(B6) is given to prevent peripheral neuritis Withhold drug if weakness or jaundice is occurring Report visual disturbances Monitor closely (Diabetes) F/U assessments and eye exams

Nursing Process- Assessment (Pre-administration assessment)

-Measure AST and ALT, obtain baseline vitals and labs. -Reduce dose with dysfunction and or alcoholism - CxR and AFB Sputums

Assessment Why would you hold or not give this med?

LFT (damage to liver), Allergies,

Evaluation
Negative sputum cultures for AFB Decrease neurotoxic drug effects Symptomatic improvement (decrease fever, secretions, increase appetite.)