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    Benzo Chart

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    nateman216
    This document summarizes various classes of drugs that act on the GABA receptor complex, including their half-life, uses, and receptor binding properties. It lists benzodiazepines like diazepam, chlordiazepoxide, lorazepam, and alprazolam that are used as anticonvulsants, muscle relaxants, and anxiolytics. It also mentions the benzodiazepine antagonist flumazenil, ethanol which acts on the α subunit, and barbiturates like thiopental and phenobarbital. Non-sedating anxiolytics such as buspirone and propranolol are also summarized.

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    Benzo Chart

    Uploaded by

    nateman216
    30 views1 page
    This document summarizes various classes of drugs that act on the GABA receptor complex, including their half-life, uses, and receptor binding properties. It lists benzodiazepines like diazepam, chlordiazepoxide, lorazepam, and alprazolam that are used as anticonvulsants, muscle relaxants, and anxiolytics. It also mentions the benzodiazepine antagonist flumazenil, ethanol which acts on the α subunit, and barbiturates like thiopental and phenobarbital. Non-sedating anxiolytics such as buspirone and propranolol are also summarized.

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    This document summarizes various classes of drugs that act on the GABA receptor complex, including their half-life, uses, and receptor binding properties. It lists benzodiazepines like diazepam, chlordiazepoxide, lorazepam, and alprazolam that are used as anticonvulsants, muscle relaxants, and anxiolytics. It also mentions the benzodiazepine antagonist flumazenil, ethanol which acts on the α subunit, and barbiturates like thiopental and phenobarbital. Non-sedating anxiolytics such as buspirone and propranolol are also summarized.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
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    Download as doc, pdf, or txt
    30 views1 page

    Benzo Chart

    Uploaded by

    nateman216
    This document summarizes various classes of drugs that act on the GABA receptor complex, including their half-life, uses, and receptor binding properties. It lists benzodiazepines like diazepam, chlordiazepoxide, lorazepam, and alprazolam that are used as anticonvulsants, muscle relaxants, and anxiolytics. It also mentions the benzodiazepine antagonist flumazenil, ethanol which acts on the α subunit, and barbiturates like thiopental and phenobarbital. Non-sedating anxiolytics such as buspirone and propranolol are also summarized.

    Copyright:

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    Class Drugs Half­Life (P450) Uses Receptor Binding

    Benzodiazepines Diazepam 43h, metabolite 200h Anticonvulsant, muscle relaxant, anxiolytic Bind to BDZ1 & BDZ2  on γ2 


    Chlordiazepoxide 10h, metabolite 200h subunit of GABAa Cl­ 
    Lorazepam 14h Sedate/anxiolytic, anticonvulsant channel complex
    Flurazepam 74h, metabolite 100h
    Alprazolam 12h Sedation/anxiolytic
    Midazolam 1.9h, IV Anesthesia, calm, ant. amnesia
    Triazolam 2.9h Induce sleep
    Zolpidem/Ambie 2h Sleeping w/o muscle relax/ACV, not much of a  BDZ1/omega1 selective on γ2
    n hangover
    Benzodiazepine  Flumazenil N/A Benzo antagonist for OD, higher affinity for  BDZ1 & BDZ2  on γ2
    Antidote receptor
    Recreation Ethanol N/A Recreation, synergy comps α subunit
    Barbiturates Thiopental N/A Lipid soluble, faston/off Anesthesia. Tissue  Bind to α or β subunits
    redistribution. 
    Phenobarbital T1/2 4­5days Less lipid, anti­epileptic.anticonv
    Non­Sedating  Buspirone N/A Anxiolytic w/o sedative effects 5HT1a ag. 
    Anxiolytics Propranolol N/A Block stage fright peripheral B­blocker

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