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Polysorbate 80, also known as polyoxyethylene
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viscous liquid with a slightly bitter taste. It is used
primarily as an emulsifier in food products, cosmetics,
vitamins, medicines, and vaccines. The product is a
derivative of sorbitol and oleic acid, and is manufactured
worldwide
Emulsifiers help bind ingredients together and keep them
from separating, most commonly with oil and water. It is
also a surfactant a substance which reduces the surface
tension of a liquid which results in an easier, smoother
spread. Frequently, it is used in ice cream and frozen
desserts to resist mel ng. Polysorbate 80 is also used as an
emulsifier and surfactant in products such as shortening,
condiments, chewing gum, dietary foods, and whipped
dessert toppings, as well as a host of cosmetic creams and
lotions.
Polysorbate 80 is also used as a solubilizer, meaning that it
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medications.
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and preparation of some foods, such as poultry. By
contrast, it can be used in products not intended for
consumption such as herbicides.
In the 1980s, Polysorbate 80 was put forward as a
potential cure for baldness, and was initially well received;
however, in 1986, a lengthy hearing involving
manufacturers, the United States (US) Food and Drug
Administration (FDA), the Federal Trade Commission (FTC),
and the US Postal Service, a court ruling prevented
manufacturers from making anti-baldness claims. Since
that time, it may still be purchased as a hair and scalp
treatment, provided there are no hair growth claims.
Polysorbate 80 is also used in some eye drops -e.g., ROHTO
cool redness. reliever/lubricant eye dropsDataThe cri cal micelle concentra on of polysorbate 80 in
pure water is reported as 0.012 mM.
Food use Polysorbate 80 is used as an emulsier in foods,
particularly in ice cream. Here, polysorbate is added to up
to 0.5% (v/v) concentra on and makes the ice cream
smoother and easier to handle, as well as increasing its
resistance to melting. Adding this substance prevents milk
proteins from completely coating the fat droplets. This
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hold air in the mixture, and provide a firmer texture that
holds its shape as the ice cream melts.
Medical use Polysorbate 80 is an excipient that is used to

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parenteral administration, and used as an emulsifier in the
manufacture of the popular anti-arrhythmic amiodarone.
It is also used as an excipient in some European and
Canadian influenza vaccines. It is also used in the culture
of Mycobacterium tuberculosis in Middlebrook 7H9 broth.
Laboratory useSome mycobacteria contain a type of lipase
(enzyme that breaks up lipid molecules). When added to a
mixture of Tween 80 and phenol red, they cause the
solution to change colour, so this is used as a test to
identify the phenotype of a strain or isolate.
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people eat about 100 mg of polysorbate 80 in foods per
day. Influenza vaccines contain 25 g of polysorbate 80 per
dose.
In general, polysorbate 80 is safe and well-tolerated,
although a small number of people may be sensitive to
this substance, and it may be harmful to people with
Crohn's disease.
Polysorbate 80 is not carcinogenic.
See alsoPolysorbate 20: Used as a we ng agent in mouth
drops.
Polysorbate 40
Polysorbate 60: Used as an emulsier in powdered drink
preparations such as hot cocoa mix.
Polysorbate 65
References1.^ Merck Index, 13th Edi on, 7664.
2.^ US PTO TESS Registry Number 2885675
3.^ Chou DK, Krishnamurthy R, Randolph TW, Carpenter
JF, Manning MC - June 2005
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Are coal tar preparations safe

Coal tar preparation have been used for over a hundred
years to treat psoriasis. However, coal tar does contain
some substances that are recognised carcinogens
(substances that may potentially cause cancer). So, over
time, some doubt about the safety of coal tar has been
raised including the possibility that its use may lead to an
increased risk of some cancers. Supporting this, some
studies have shown an increased risk of cancer in animals
.exposed to coal tar or in people who work with coal tar

( Reem50 ) ..

..

However, the results of a large study involving over 13,000

people who have used coal tar preparations to treat
psoriasis or eczema were published recently. The study did
not find any link between the use of preparations
containing coal tar and an increased risk of cancer
.((including skin cancer and other cancers
..
.. ..
..
..
.. ..


....
..
LIQUOR PICIS CARBONIS B. P
By
.I. BERENBLUM, M.D., M.Sc
From the Oxford University Researchof the British)
Empire Campaign, Sir William Dunn School of
(Pathology, University of Oxford

( Reem50 ) ..

..

From our knowledge of occupational in Dermatologyand

The effects of successful coal tar on human skin and skin
diseases, especially for
psoriasis, eczema and more than 5000 skin disease is a
coal tar active substance for the treatment of these
.....................diseases
from results of experiments, coal-tar must be considered
among the most potent for skin
.epithelium
The corresponding preparation in use in this country is
liquor picis carbonis (B.P.), which consists of a 20%
solution
of coal-tar,in ethanol. In view of its wide use in
dermatological practice an experimental investigation of
suggested by Dr. J. R. Squire, of the M.R.C. Industria
Medicine Research Unit, Birmingham Accident Hospital
and by Dr. E. H. Capel, late medical officer to Joseph
.Lucas Ltd., Birmingham
..

//

( Reem50 ) ..

 ..

,
Journal
of Investigative Dermatology

No increased risk of cancer after coal tar
treatment in patients with psoriasis or
eczema



This study has sufficient power to show
that coal tar treatment is not associated
with an increased risk of cancer. These
results indicate that coal tar can be
maintained as a safe treatment in
dermatological practice


) (

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Coal tar is an effective treatment for
psoriasis and eczema, but it contains
several carcinogenic compounds.
Occupational and animal studies have
shown an increased risk of cancer after
exposure to coal tar. Many dermatologists
have abandoned this treatment for safety
reasons, although the risk of cancer after
coal tar in dermatological practice is
unclear


)

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http://www.ncbi.nlm.nih.gov/pubmed/20
016499
http://www.nature.com/jid/journal/v1...d
2009389a.html

.. ) ( Reem50

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No increased risk of cancer after coal tar
treatment in patients with psoriasis or
eczema
Roelofzen JH, Aben KK, Oldenhof UT,
Coenraads PJ, Alkemade HA, van de
Kerkhof PC, van der Valk PG, Kiemeney LA.
Source
Department of Epidemiology, Biostatistics
and HTA, Radboud University Nijmegen
Medical Centre, Nijmegen, The
Netherlands. J.Roelofzen@derma.umcn.nl

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It is advised that pregnant women should not use

coal tar treatments during the first three months of
pregnancy. However, they are thought to be safe to
use later in your pregnancy. You can use coal tar
treatments while you are breast-feeding

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