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Stroke / Ischaemia

Frequency/ Prevalence

Germany: 200 000 / year, 20-30 % die during the following 4 weeks 30 % need continuous medical care 1 million suffers from the consequences 1998 health costs only: 15 billions DM Prognosis: in 2030: 40 % increase
USA 550 000/ year

Symptoms Abruptly occurring neurological symptoms

Cause
Global ischaemia cardiac arrest (case R. B.) Perinatal asphyxia Local ischaemia Closure of a blood vessel Rupture of a blood vessel

Neurochemistry
See excitotoxicity of glutamate

Therapy
No causal therapy today In the future: Glu-Receptor cluster manipulations Elucidation of the neurodegenrative pathways

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