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Definition of "abortion" and "viability" Abortion and miscarriage both refer to first trimester pregnancy losses (<500g or 20 wks

EGA = limits of viability) II. Incidence and possible etiologies of "spontaneous abortion" A. Miscarriage is the most common complication of pregnancy, 15% incidence among clinically recognized pregnancies, prevalence inc. with maternal age (12% < 20 YO, 50% >45 YO) B. Embryonic factors: abnormal germ cells, defective implantation of normal trophoblast, injury to developing embry C. Chromosomal abnormalities: 60% of first trimester losses, dec. to 7% @ 24 weeks (autosomal trisomies 16/21/22 > monsomy X > triploidy > tetraploidy > translocations > mosaics) and parental factors (balanced translocations) D. Endocrine:luteal phase defect (no pregesterone secretion by corpus luteum or deficiency of progesterone receptors in endometrium. Hypothyroidism E. Anatomical abnormalities of uterus: cervical incompetence, uterine structural/formation defects F. Infectous dz: rubella, herpes, CMV, toxo G. Systemic dz; nutritional deficiency, DM, SLE (40% SAB rate) III. Difference between: A. Threatened abortion: Cervix closed and uneffaced, first trimester bleeding in 25% of pregnancies. No convincing evidence that treatments influence outcome, be sympathetic. Bedrest, progesterone, no sex, evacuation of uterus if bleeding excessive/persistent, cerclage B. Inevitable abortion: bleeding or SROM with pain and cervical dilation, it's inevitable; deliver or D&C C. Incomplete abortion: partial passage of products of conception (POC), evacuate uterus to prevent further hemorrhage or infection, follow with methergine/pitocin, always check pathology (mole) D. Missed abortion: expulsion does not occur for prolonged period after fetal death (>6wks). Suction curretage in first trimester, D&E in second trimester (laminaria pre-op) or prostaglandin E2. IV. Appropriate plan of management for each clinical situation V. Definition of "induced abortion" A. Caused by iatrogenic intervention VI. Definition of "habitual abortion" A. Recurrent spontaneous abortion (RSA): three or more consecutive first-trimester losses. Check for uterine abnormalities and rare Ab (lupus anticoagulant, anticardiolipin Ab)

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