Spirit 13

Abstract Format for Scientific Events

Event Name:- Polaris :PG Poster Presentation

Name of Author:-vijay kumar gupta Email :-kumarvijaygupta001@gmail.com Contact Number :-9334951104 Co-Author (Team Details) o 1) M D. Azharuddin o 2)saroj kumar

Name of the Guide (only for UG students):- . (Dr.) A. Nath, (Dr.) Ranjit Kumar College Name and address:-bihar college of pharmacy ,patna

Topic:- Bio remedial effect of Withania somnifera on the kidney of endosulfan

induced swiss albino mice

Abstract (125-175 words):-

Pest control chemicals are poisons and they may present immediate danger to user if used improperly. Some of them highly toxic and may cause serious metabolic disorders. Endosulfan is reported to be one of the most toxic pesticides in the market today with its widespread use in agriculture, human are most likely to be exposed to it by eating food contaminated with endosulfan. Population that are usually susceptible to endosulfan include the unborn and neonates, the elderly and people with liver, kidney, immunological haematological or neurological disease (ATSDR 2000). This kind of adverse effect of endosulfan can be reduced

by using herbal Withania somnifera. W. somnifera is widely used in ayurvedic medicine, the traditional medical system of India, It also known as Ashwagandha, Indian ginseng, winter cherry, is a plant in the Solanaceae family. Ashwagandha is reported to having anticarcinogenic, anti-oxidant effect in animal .The mice were administered 3 mg Endosulfan per kg b. w for 4 week and distilled water chosen as the preferred vehicle . While, herbal powdered extract of Withania somnifera was ground into a fine suspension in 10 ml of distilled water and administeration of dose 600 mg per kg body weight for 6 week. Thus, it is concluded from entire study that endosulfan causes severe alteration in histology of kidney of mice. This hampers normal filtration in animal. It also causes biochemical alteration, while withania administration causes little restoration in histology of kidney of mice. Chemical parameters were also increased in Withania somnifera administered group, which finally indicate that have little restoration on histology and biochemical parameters of kidney against endosulfan toxicity.