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    Multidisciplinary Treatment of Gastrointestinal Stromal Tumors discusses GIST, a unique tumor recognized only in the last decade. Successful treatment of GIST requires pathologic and radiographic evaluation, surgical treatment, and oncologic care. GIST is a distinct disease based on KIT (CD 117) expression and PDGFRα mutations in 5% of GIST that lack KIT expression. There is interest in GIST pathology and treatment because KIT and PDGFRα mutations can be inhibited by Imatinib Mesylate, although the location of the mutation predicts response to this targeted therapy.

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    Multidisciplinary Treatment of GIST_AM

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    Multidisciplinary Treatment of Gastrointestinal Stromal Tumors discusses GIST, a unique tumor recognized only in the last decade. Successful treatment of GIST requires pathologic and radiographic evaluation, surgical treatment, and oncologic care. GIST is a distinct disease based on KIT (CD 117) expression and PDGFRα mutations in 5% of GIST that lack KIT expression. There is interest in GIST pathology and treatment because KIT and PDGFRα mutations can be inhibited by Imatinib Mesylate, although the location of the mutation predicts response to this targeted therapy.

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    5 views5 pages

    Multidisciplinary Treatment of GIST - AM

    Uploaded by

    Tjendonoharianto
    Multidisciplinary Treatment of Gastrointestinal Stromal Tumors discusses GIST, a unique tumor recognized only in the last decade. Successful treatment of GIST requires pathologic and radiographic evaluation, surgical treatment, and oncologic care. GIST is a distinct disease based on KIT (CD 117) expression and PDGFRα mutations in 5% of GIST that lack KIT expression. There is interest in GIST pathology and treatment because KIT and PDGFRα mutations can be inhibited by Imatinib Mesylate, although the location of the mutation predicts response to this targeted therapy.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPTX, PDF, TXT or read online from Scribd
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    of 5

    Multidisciplinary Treatment of Gastrointestinal Stromal Tumors

    Andy Maleachi

    GIST

    A unique tumor Recognized only in the last decade

    GIST

    Requirement to successfully treat patients with GIST :


    Pathologic

    and Radiographic

    Evaluation

    Surgical Treatment Oncologic care

    GIST

    Distinct disease based on KIT (CD 117) expression PDGFR mutations in 5% of GIST that lack KIT expression

    GIST

    There is much interest in GIST pathology and treatment, because the KIT proto-oncogene and the PDGFR mutations can be inhibited by Imatinib Mesylate (Targeted therapy), although the location of mutation will also predict their responses

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