Brand name: Ciprobay

Generic name: Ciprofloxacin

Drug Classification: Antibiotics (Quinolones)
Indications: Infections of the respiratory tract, middle ear, sinuses, eyes, kidneys and urinary tract,
genital organs, abdomen, skin and soft tissues, bones and joints; further, septicemia,
infections in patients with reduced host defense and for selective intestinal
decontamination in immuno suppressed patients.
Mechanism of action: Inhibits DNA-gyrase in susceptible organism; inhibits relaxation of
supercoiled DNA and promotes breakage of double-stranded DNA.
Dose: Tab 125-750 mg orally bid. Respiratory tract infections 500 mg bid. Acute gonorrhea 250
mg orally as single dose. The normal dose must be reduced if creatinine clearance is <
20 ml/min. 500 XR tab acute uncomplicated UTI (acute cystitis) 1 tab/day for 3 days IV
infusion 100-200 mg bid. Resp tract infections 200-400 mg bid. Acute, uncomplicated
UTI and extra genital gonorrhea 100 mg bid. Pre-menopausal cystitis and acute,
uncomplicated gonorrhea single dose 100 mg. Complicated cystitis and diarrhea 200 mg
bid. Severe infections 400 mg tid.
Contraindication: hypersensitivity to ciprofloxacin or other quinolones. Children, adolescents,
pregnancy and lactation.
Special Precautions: Epilepsy, CNS damage. Photosensitivity. May affect ability to drive or
operate machinery.
Adverse Reactions:
CNS: seizures, dizziness, drowsiness, headache, insomnia, acute psychosis, agitation,
confusion, hallucination, increased intracranial pressure, light-headedness, tremors
CV: arrythmias, QT prolongation, vasodilation
GI: hepatotoxicity, pseudomembranous colitis, abdominal pain, diarrhea, nausea, altered
taste. GU: interstitial cystitis, vaginitis. Derm: photosensitivity, phototoxicity
Endo: hyperglycemia, hypoglycemia. Local: phlebitis at IV site
MS: tendonitis, tendon rupture
Misc: hypersensitivity reactions including anaphylaxis, Stevens - Johnson syndrome,
lymphadenopathy.
Form: Tablet (Film- coated) - 250mg, 500mg, 750mg; IV infusion- 100mg/ 50mL,
200mg/ 100mL, 400mg/ 200mL
Pregnancy Risk Category: C
Nursing Responsibilities:
 Assess patient for infection prior to and during therapy.
 Obtain specimens for culture and sensitivity before initiating therapy
 Observe patient for signs and symptoms of anaphylaxis (rash, pruritus, laryngeal
edema, wheezing)
 Monitor prothrombin time closely in patients receiving fluoroquinolones and
warafarin