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    Jayvee Cruz
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    Lactulose is a hyperosmotic laxative used to treat constipation and prevent portal-systemic encephalopathy. It works by being fermented by colonic bacteria into organic acids that increase colonic osmotic pressure and acidity, softening stool and increasing water content for easier bowel movements. This also helps migrate blood ammonia into stool for removal. Side effects include abdominal discomfort and flatulence. Nurses should assess for allergies or conditions contraindicating its use and monitor for diarrhea or electrolyte imbalances.

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    Lactulose is a hyperosmotic laxative used to treat constipation and prevent portal-systemic encephalopathy. It works by being fermented by colonic bacteria into organic acids that increase colonic osmotic pressure and acidity, softening stool and increasing water content for easier bowel movements. This also helps migrate blood ammonia into stool for removal. Side effects include abdominal discomfort and flatulence. Nurses should assess for allergies or conditions contraindicating its use and monitor for diarrhea or electrolyte imbalances.

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    18 views1 page

    Drug Study

    Uploaded by

    Jayvee Cruz
    Lactulose is a hyperosmotic laxative used to treat constipation and prevent portal-systemic encephalopathy. It works by being fermented by colonic bacteria into organic acids that increase colonic osmotic pressure and acidity, softening stool and increasing water content for easier bowel movements. This also helps migrate blood ammonia into stool for removal. Side effects include abdominal discomfort and flatulence. Nurses should assess for allergies or conditions contraindicating its use and monitor for diarrhea or electrolyte imbalances.

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    DRUG, DOSAGE & ROUTE

    Generic name: Lactulose Brand name: Anulose Classificatio n Laxative Hyperosmo tic

    MECHANISM OF ACTION
    The drug passes unchanged into the colon where bacteria break it down to organic acids that increase the osmotic pressure in the colon and slightly acidify the colonic contents, resulting in an increase in stool water content, stool softening, laxative action. This also results in migration of blood ammonia into the colon contents with subsequent trapping and expulsion of feces.

    INDICATI ONS
    Treatment of constipatio n. Prevention and treatment of portalsystemic encephalop athy.

    CONTRAINDICATION S
    Contraindicated with allergy to lactulose, lowgalactose diet. Use cautiously with diabetes, pregnancy, and lactation.

    ROUTE AND DOSAGE


    5-10gtts OD PO

    SIDE EFFECTS and ADVERSE REACTIONS


    SE: Abdominal fullness, flatulence, belching. AR: GI Transient flatulence, distention, intestinal cramps, belching, diarrhea, nausea. Other Acid-base imbalances

    NURSING RESPONSIBILITIES
    History Allergy to lactulose, low-galactose diet. diabetes, pregnancy, and lactation. Physical Abdominal examination, bowel sounds, serum electrolytes, serum ammonia levels. Do not freeze laxative form. Ask patient to report diarrhea, severe belching, abdominal fullness.

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