Table 3 - Intravenous Agents

Typical Initial Clinical

Drug Clinical Onset
Dose Duration
Thiopentone 4-5 mg/kg 20-30 sec 5-10 min
Propofol 1.5-2.5 mg/kg 1-2 min 5-10 min
Midazolam 0.01-0.1 mg/kg 2-4 min 1-2 hrs
Diazepam 0.02-0.2 mg/kg 3-6 min 4-8 hrs
Fentanyl 1-1.5 mcg/kg 1-4 min 2-3 hrs
0.05-0.15
Morphine 3-10 min 2-3 hrs
mg/kg
Pethidine 0.5-1.5 mg/kg 2-5 min 2-3 hrs
Ketamine 1-2 mg/kg 20-30 sec 5-10 min
Table 4 - Inhalation Agents
Blood/Gas
Concentration Oil/water
Agent MAC* partition
used solubility
coefficient
Ether 1.92 2-15% 12 3
Halothane 0.76 0.5-3% 2.3 220
Enflurane 1.68 1-6% 1.9 120
Isoflurane 1.15 1-4% 1.4 120
Sevoflurane 2 1-6% 0.69 53
Nitrous Oxide 104 70% 0.47 2.2
Table 5 - Muscle Relaxants
Approximate duration
Drug Initial Dose mg/kg
(min)
d-Tubocurarine 0.5 25-30
Alcuronium 0.3 20-25
Gallamine 1-2 20-30
Pancuronium 0.1 30-45
Vecuronium 0.1 15-20
Atracurium 0.5 20-25
Cisatracurium 0.15 20-25
Mivacurium 0.2 10-20
Rocuronium 0.6 20-30
Suxamethonium 1-1.5 3-5
Table 6 - Resuscition Drugs
 Drug Recommended Dose Average Adult Dose
Adrenaline 0.01-0.05 mg/kg 0.5-1mg
Atropine 0.02 mg/kg 0.6-1.2 mg
Calcium Chloride 0.2 ml/kg (10%) 5-10 mL
Lignocaine 1 mg/kg 10 mL 1%
● Local anaesthetics - lignocaine, bupivacaine, ropivacaine, cinchocaine.